scholarly journals A preliminary study of the effects of mindfulness‐based cognitive therapy on structural brain networks in mood‐dysregulated youth with a familial risk for bipolar disorder

2021 ◽  
Author(s):  
Jing Yang ◽  
Du Lei ◽  
Xueling Suo ◽  
Maxwell J. Tallman ◽  
Kun Qin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Therapy ◽  
Brain Networks ◽  
Familial Risk ◽  
Preliminary Study ◽  
Structural Brain

scholarly journals 28.4 A PRELIMINARY STUDY OF THE MINDFULNESS BASED COGNITIVE THERAPY ON BRAIN NETWORKS OF YOUTH WITH MOOD DYSREGULATION

2021 ◽  
Vol 60 (10) ◽  
pp. S301-S302
Author(s):  
Melissa P. DelBello ◽  
Du Lei ◽  
Jing Yang ◽  
Kun Quin ◽  
Max Tallman ◽  
...  
Keyword(s):  
Cognitive Therapy ◽  
Brain Networks ◽  
Preliminary Study ◽  
Mood Dysregulation

scholarly journals Network-level functional topological changes after mindfulness-based cognitive therapy in mood dysregulated adolescents at familial risk for bipolar disorder: a pilot study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kun Qin ◽  
Du Lei ◽  
Jing Yang ◽  
Wenbin Li ◽  
Maxwell J. Tallman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Cognitive Therapy ◽  
Path Length ◽  
Small Sample Size ◽  
Functional Integration ◽  
Familial Risk ◽  
Small Sample ◽  
Adverse Outcomes ◽  
Characteristic Path Length

Abstract Background Given that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents. Methods Ten mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis. Results Following MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score. Conclusions 12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.

scholarly journals Topological properties of large-scale structural brain networks in children with familial risk for reading difficulties

NeuroImage ◽  
2013 ◽  
Vol 71 ◽  
pp. 260-274 ◽  
Author(s):  
S.M. Hadi Hosseini ◽  
Jessica M. Black ◽  
Teresa Soriano ◽  
Nicolle Bugescu ◽  
Rociel Martinez ◽  
...  
Keyword(s):  
Large Scale ◽  
Brain Networks ◽  
Familial Risk ◽  
Reading Difficulties ◽  
Topological Properties ◽  
Structural Brain

scholarly journals Intergenerational transmission of the patterns of functional and structural brain networks

iScience ◽  
2021 ◽  
pp. 102708
Author(s):  
Yu Takagi ◽  
Naohiro Okada ◽  
Shuntaro Ando ◽  
Noriaki Yahata ◽  
Kentaro Morita ◽  
...  
Keyword(s):  
Intergenerational Transmission ◽  
Brain Networks ◽  
Structural Brain

scholarly journals Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

2021 ◽  
Author(s):  
Nora Penzel ◽  
◽  
Linda A. Antonucci ◽  
Linda T. Betz ◽  
Rachele Sanfelici ◽  
...  
Keyword(s):  
Gray Matter ◽  
Inferior Frontal Gyrus ◽  
Brain Networks ◽  
Developmental Trajectory ◽  
Cannabis Use ◽  
Brain Maturation ◽  
Confounding Factors ◽  
Recent Onset ◽  
Increased Risk ◽  
Structural Brain

AbstractCannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation during this vulnerable period. However, studies investigating the interaction between early cannabis use and brain structural alterations hitherto reported inconclusive findings. We investigated effects of age of cannabis initiation on psychosis using data from the multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) and the Cannabis Induced Psychosis (CIP) studies, yielding a total sample of 102 clinically-relevant cannabis users with recent onset psychosis. GM covariance underlies shared maturational processes. Therefore, we performed source-based morphometry analysis with spatial constraints on structural brain networks showing significant alterations in schizophrenia in a previous multisite study, thus testing associations of these networks with the age of cannabis initiation and with confounding factors. Earlier cannabis initiation was associated with more severe positive symptoms in our cohort. Greater gray matter volume (GMV) in the previously identified cerebellar schizophrenia-related network had a significant association with early cannabis use, independent of several possibly confounding factors. Moreover, GMV in the cerebellar network was associated with lower volume in another network previously associated with schizophrenia, comprising the insula, superior temporal, and inferior frontal gyrus. These findings are in line with previous investigations in healthy cannabis users, and suggest that early initiation of cannabis perturbs the developmental trajectory of certain structural brain networks in a manner imparting risk for psychosis later in life.

Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study

2019 ◽  
Vol 247 ◽  
pp. 114-119 ◽  
Author(s):  
Fadwa Cazala ◽  
Isabelle E. Bauer ◽  
Thomas D. Meyer ◽  
Danielle E. Spiker ◽  
Iram F. Kazimi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Children And Adolescents ◽  
Childhood Trauma ◽  
Preliminary Study

scholarly journals Lithium monotherapy associated longitudinal effects on resting state brain networks in clinical treatment of bipolar disorder

2018 ◽  
Vol 21 (4) ◽  
pp. 361-371 ◽  
Author(s):  
Jeffrey M Spielberg ◽  
Melanie A Matyi ◽  
Harish Karne ◽  
Amit Anand
Keyword(s):  
Bipolar Disorder ◽  
Resting State ◽  
Brain Networks ◽  
Clinical Treatment ◽  
Longitudinal Effects

scholarly journals Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: A preliminary study

2014 ◽  
Vol 224 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Drew Barzman ◽  
Jim Eliassen ◽  
Robert McNamara ◽  
Pablo Abonia ◽  
Douglas Mossman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Pediatric Bipolar Disorder ◽  
Functional Activities ◽  
Inflammatory Gene ◽  
Preliminary Study
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