Clinical evaluation of a topical treatment with ascorbyl tetraisopalmitate nanoencapsulated, retinol, and glycolic acid in photoaged human skin

2014 ◽  
Vol 70 (5) ◽  
pp. AB14
Keyword(s):  
Human Skin ◽  
Clinical Evaluation ◽  
Topical Treatment ◽  
Glycolic Acid

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin

2008 ◽  
Vol 17 (11) ◽  
pp. 946-952 ◽  
Author(s):  
Marek Haftek ◽  
Sophie Mac-Mary ◽  
Marie-Aude Le Bitoux ◽  
Pierre Creidi ◽  
Sophie Seité ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Human Skin ◽  
Topical Treatment ◽  
Long Term Effects ◽  
Structural Evaluation

scholarly journals Enhanced Transdermal Delivery of Pranoprofen Using a Thermo-Reversible Hydrogel Loaded with Lipid Nanocarriers for the Treatment of Local Inflammation

2021 ◽  
Vol 15 (1) ◽  
pp. 22
Author(s):  
María Rincón ◽  
Marcelle Silva-Abreu ◽  
Lupe Carolina Espinoza ◽  
Lilian Sosa ◽  
Ana Cristina Calpena ◽  
...  
Keyword(s):  
Human Skin ◽  
Topical Application ◽  
Topical Treatment ◽  
Transdermal Delivery ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vitro Release ◽  
Heterogeneous Structure ◽  
Clinical Environment ◽  
Local Skin

A biocompatible topical thermo-reversible hydrogel containing Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs) was studied as an innovative strategy for the topical treatment of skin inflammatory diseases. The PF-NLCs-F127 hydrogel was characterized physiochemically and short-time stability tests were carried out over 60 days. In vitro release and ex vivo human skin permeation studies were carried out in Franz diffusion cells. In addition, a cytotoxicity assay was studied using the HaCat cell line and in vivo tolerance study was performed in humans by evaluating the biomechanical properties. The anti-inflammatory effect of the PF-NLCs-F127 was evaluated in adult male Sprague Daw-ley® rats using a model of inflammation induced by the topical application of xylol for 1 h. The developed PF-NLCs-F127 exhibited a heterogeneous structure with spherical PF-NLCs in the hydrogel. Furthermore, a thermo-reversible behaviour was determined with a gelling temperature of 32.5 °C, being close to human cutaneous temperature and thus favouring the retention of PF. Furthermore, in the ex vivo study, the amount of PF retained and detected in human skin was high and no systemic effects were observed. The hydrogel was found to be non-cytotoxic, showing cell viability of around 95%. The PF-NLCs-F127 is shown to be well tolerated and no signs of irritancy or alterations of the skin’s biophysical properties were detected. The topical application of PF-NLCs-F127 hydrogel was shown to be efficient in an inflammatory animal model, preventing the loss of stratum corneum and reducing the presence of leukocyte infiltration. The results from this study confirm that the developed hydrogel is a suitable drug delivery carrier for the transdermal delivery of PF, improving its dermal retention, opening the possibility of using it as a promising candidate and safer alternative to topical treatment for local skin inflammation and indicating that it could be useful in the clinical environment.

Effects of superoxide dismutase topical treatment on human skin radiofibrosis: a pathological study

The Breast ◽  
1996 ◽  
Vol 5 (2) ◽  
pp. 75-81 ◽  
Author(s):  
B. Benyahia ◽  
F. Campana ◽  
B. Perdereau ◽  
E. Gez ◽  
A. Fourquet ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Human Skin ◽  
Topical Treatment ◽  
Pathological Study

scholarly journals Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 527 ◽  
Author(s):  
Rancan ◽  
Contardi ◽  
Jurisch ◽  
Blume-Peytavi ◽  
Vogt ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Skin ◽  
Topical Treatment ◽  
Ex Vivo ◽  
Healing Process ◽  
Delivery Systems ◽  
Water Soluble ◽  
Local Drug Delivery ◽  
Model Based ◽  
Nanofiber Mats

Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more selective and sustained local drug delivery is achieved. In this study, a poorly water-soluble antibiotic, ciprofloxacin, was loaded on polyvinylpyrrolidone (PVP)-based foils and nanofiber mats using acetic acid as a solubilizer. Drug delivery kinetics, local toxicity, and antimicrobial activity were tested on an ex vivo wound model based on full-thickness human skin. Wounds of 5 mm in diameter were created on 1.5 × 1.5 cm skin blocks and treated with the investigated materials. While nanofiber mats reached the highest amount of delivered drug after 6 h, foils rapidly achieved a maximum drug concentration and maintained it over 24 h. The treatment had no effect on the overall skin metabolic activity but influenced the wound healing process, as observed using histological analysis. Both delivery systems were efficient in preventing the growth of Pseudomonas aeruginosa biofilms in ex vivo human skin. Interestingly, foils loaded with 500 µg of ciprofloxacin accomplished the complete eradication of biofilm infections with 1 × 109 bacteria/wound. We conclude that antimicrobial-loaded resorbable PVP foils and nanofiber mats are promising delivery systems for the prevention or topical treatment of infected wounds.

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