scholarly journals Representation of Older Adults in the Late-Breaking Clinical Trials American Heart Association 2011 Scientific Sessions

2012 ◽  
Vol 60 (9) ◽  
pp. 869-871 ◽  
Author(s):  
Philip Green ◽  
Mathew S. Maurer ◽  
Joanne M. Foody ◽  
Daniel E. Forman ◽  
Nanette K. Wenger
2007 ◽  
Vol 9 (1) ◽  
pp. 92-97 ◽  
Author(s):  
John G.F. Cleland ◽  
Alison P. Coletta ◽  
Ahmed Tageldien Abdellah ◽  
Mansoor Nasir ◽  
Neil Hobson ◽  
...  

Circulation ◽  
2020 ◽  
Vol 141 (2) ◽  
Author(s):  
Abdulla A. Damluji ◽  
Daniel E. Forman ◽  
Sean van Diepen ◽  
Karen P. Alexander ◽  
Robert L. Page ◽  
...  

Longevity is increasing, and more adults are living to the stage of life when age-related biological factors determine a higher likelihood of cardiovascular disease in a distinctive context of concurrent geriatric conditions. Older adults with cardiovascular disease are frequently admitted to cardiac intensive care units (CICUs), where care is commensurate with high age-related cardiovascular disease risks but where the associated geriatric conditions (including multimorbidity, polypharmacy, cognitive decline and delirium, and frailty) may be inadvertently exacerbated and destabilized. The CICU environment of procedures, new medications, sensory overload, sleep deprivation, prolonged bed rest, malnourishment, and sleep is usually inherently disruptive to older patients regardless of the excellence of cardiovascular disease care. Given these fundamental and broad challenges of patient aging, CICU management priorities and associated decision-making are particularly complex and in need of enhancements. In this American Heart Association statement, we examine age-related risks and describe some of the distinctive dynamics pertinent to older adults and emerging opportunities to enhance CICU care. Relevant assessment tools are discussed, as well as the need for additional clinical research to best advance CICU care for the already dominating and still expanding population of older adults.


2020 ◽  
Vol 9 (17) ◽  
Author(s):  
Daniel H. Craighead ◽  
Kaitlin A. Freeberg ◽  
Douglas R. Seals

Background Impaired endothelial function is thought to contribute to the increased cardiovascular risk associated with above‐normal blood pressure (BP). However, the association between endothelial function and BP classified by 2017 American College of Cardiology/American Heart Association guidelines is unknown. Our objective was to determine if endothelial function decreases in midlife/older adults across the 2017 American College of Cardiology/American Heart Association guidelines BP classifications and identify associated mechanisms of action. Methods and Results A retrospective analysis of endothelial function (brachial artery flow‐mediated dilation) from 988 midlife/older adults (aged 50+ years) stratified by BP status (normal BP; elevated BP; stage 1 hypertension; stage 2 hypertension) was performed. Endothelium‐independent dilation (sublingual nitroglycerin), reactive oxygen species–mediated suppression of endothelial function (∆brachial artery flow‐mediated dilation with vitamin C infusion), and endothelial cell and plasma markers of oxidative stress and inflammation were assessed in subgroups. Compared with normal BP (n=411), brachial artery flow‐mediated dilation was 12% ( P =0.04), 15% ( P <0.01) and 20% ( P <0.01) lower with elevated BP (n=173), stage 1 hypertension (n=248) and stage 2 hypertension (n=156), respectively, whereas endothelium‐independent dilation did not differ ( P =0.14). Vitamin C infusion increased brachial artery flow‐mediated dilation in those with above‐normal BP ( P ≤0.02) but not normal BP ( P =0.11). Endothelial cell p47 phox ( P <0.01), a marker of superoxide/reactive oxygen species–generating nicotinamide adenine dinucleotide phosphate oxidase, and circulating interleukin‐6 concentrations ( P =0.01) were higher in individuals with above‐normal BP. Conclusions Vascular endothelial function is progressively impaired with increasing BP in otherwise healthy adults classified by 2017 American College of Cardiology/American Heart Association guidelines. Impaired endothelial function with above‐normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin‐6.


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