scholarly journals Vascular Endothelial Function in Midlife/Older Adults Classified According to 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines

2020 ◽  
Vol 9 (17) ◽  
Author(s):  
Daniel H. Craighead ◽  
Kaitlin A. Freeberg ◽  
Douglas R. Seals
Keyword(s):  
Reactive Oxygen Species ◽  
Older Adults ◽  
Endothelial Function ◽  
Brachial Artery ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
Flow Mediated Dilation ◽  
Oxygen Species ◽  
Artery Flow

Background Impaired endothelial function is thought to contribute to the increased cardiovascular risk associated with above‐normal blood pressure (BP). However, the association between endothelial function and BP classified by 2017 American College of Cardiology/American Heart Association guidelines is unknown. Our objective was to determine if endothelial function decreases in midlife/older adults across the 2017 American College of Cardiology/American Heart Association guidelines BP classifications and identify associated mechanisms of action. Methods and Results A retrospective analysis of endothelial function (brachial artery flow‐mediated dilation) from 988 midlife/older adults (aged 50+ years) stratified by BP status (normal BP; elevated BP; stage 1 hypertension; stage 2 hypertension) was performed. Endothelium‐independent dilation (sublingual nitroglycerin), reactive oxygen species–mediated suppression of endothelial function (∆brachial artery flow‐mediated dilation with vitamin C infusion), and endothelial cell and plasma markers of oxidative stress and inflammation were assessed in subgroups. Compared with normal BP (n=411), brachial artery flow‐mediated dilation was 12% ( P =0.04), 15% ( P <0.01) and 20% ( P <0.01) lower with elevated BP (n=173), stage 1 hypertension (n=248) and stage 2 hypertension (n=156), respectively, whereas endothelium‐independent dilation did not differ ( P =0.14). Vitamin C infusion increased brachial artery flow‐mediated dilation in those with above‐normal BP ( P ≤0.02) but not normal BP ( P =0.11). Endothelial cell p47 phox ( P <0.01), a marker of superoxide/reactive oxygen species–generating nicotinamide adenine dinucleotide phosphate oxidase, and circulating interleukin‐6 concentrations ( P =0.01) were higher in individuals with above‐normal BP. Conclusions Vascular endothelial function is progressively impaired with increasing BP in otherwise healthy adults classified by 2017 American College of Cardiology/American Heart Association guidelines. Impaired endothelial function with above‐normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin‐6.

scholarly journals Acute effect of Finnish sauna bathing on brachial artery flow‐mediated dilation and reactive hyperemia in healthy middle‐aged and older adults

2019 ◽  
Vol 7 (13) ◽  
Author(s):  
Hugo Gravel ◽  
Geoff B. Coombs ◽  
Parya Behzadi ◽  
Virginie Marcoux‐Clément ◽  
Hadiatou Barry ◽  
...  
Keyword(s):  
Older Adults ◽  
Brachial Artery ◽  
Reactive Hyperemia ◽  
Acute Effect ◽  
Flow Mediated Dilation ◽  
Middle Aged ◽  
Sauna Bathing ◽  
Artery Flow

scholarly journals Representation of Older Adults in the Late-Breaking Clinical Trials American Heart Association 2011 Scientific Sessions

2012 ◽  
Vol 60 (9) ◽  
pp. 869-871 ◽  
Author(s):  
Philip Green ◽  
Mathew S. Maurer ◽  
Joanne M. Foody ◽  
Daniel E. Forman ◽  
Nanette K. Wenger
Keyword(s):  
Older Adults ◽  
Clinical Trials ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association

scholarly journals Assessment of macro and microvascular function in aging males

2020 ◽  
Author(s):  
Matthew C Babcock ◽  
Lyndsey E. DuBose ◽  
Teresa L. Witten ◽  
Ashley Brubaker ◽  
Brian L. Stauffer ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Function ◽  
Sensitivity And Specificity ◽  
Brachial Artery ◽  
Healthy Adult ◽  
High Sensitivity ◽  
Flow Mediated Dilation ◽  
Peripheral Artery ◽  
Adult Men ◽  
Artery Flow

Aging is associated with reductions in endothelial function, observations primarily reported using brachial artery ultrasound. There is growing interest in the use of peripheral artery tonometry (PAT) of microvessels in the fingertip to assess endothelial function because it is less technically demanding and has a high sensitivity and specificity for assessing coronary endothelial function. Moreover, similar to brachial artery flow mediated dilation (FMD), PAT predicts cardiovascular disease (CVD) outcomes. However, the relation between PAT and FMD have yet to be examined in the context of aging. To address this question, reactive hyperemic index (RHI) using EndoPAT and flow-mediated dilation (FMD) using brachial artery ultrasound were assessed after five minutes of forearm ischemia in twenty younger (18-40 years old; 29±4 years) and twenty older (60-75 years old; 65±4 years) healthy adult men. Higher values of both FMD and RHI indicate better endothelial function. Endothelial function assessed via brachial artery FMD was lower in older (4.8±2.1%), compared to younger (7.5±1.6%) men (p<0.001). In contrast, the RHI assessed via PAT was greater in older (2.2±0.6), compared to younger (1.8±0.5) men (p=0.014). FMD and RHI were not correlated (r=-0.15; p=0.35). We conclude that PAT may not be an appropriate measure to evaluate age-associated changes in endothelial function.

scholarly journals Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association

Circulation ◽  
2020 ◽  
Vol 141 (2) ◽  
Author(s):  
Abdulla A. Damluji ◽  
Daniel E. Forman ◽  
Sean van Diepen ◽  
Karen P. Alexander ◽  
Robert L. Page ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Intensive Care ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
Assessment Tools ◽  
Age Related ◽  
Geriatric Conditions ◽  
Cardiac Intensive Care

Longevity is increasing, and more adults are living to the stage of life when age-related biological factors determine a higher likelihood of cardiovascular disease in a distinctive context of concurrent geriatric conditions. Older adults with cardiovascular disease are frequently admitted to cardiac intensive care units (CICUs), where care is commensurate with high age-related cardiovascular disease risks but where the associated geriatric conditions (including multimorbidity, polypharmacy, cognitive decline and delirium, and frailty) may be inadvertently exacerbated and destabilized. The CICU environment of procedures, new medications, sensory overload, sleep deprivation, prolonged bed rest, malnourishment, and sleep is usually inherently disruptive to older patients regardless of the excellence of cardiovascular disease care. Given these fundamental and broad challenges of patient aging, CICU management priorities and associated decision-making are particularly complex and in need of enhancements. In this American Heart Association statement, we examine age-related risks and describe some of the distinctive dynamics pertinent to older adults and emerging opportunities to enhance CICU care. Relevant assessment tools are discussed, as well as the need for additional clinical research to best advance CICU care for the already dominating and still expanding population of older adults.

scholarly journals Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function

2010 ◽  
Vol 163 (2) ◽  
pp. 359
Author(s):  
Jessica L Fargnoli ◽  
Qi Sun ◽  
Deanna Olenczuk ◽  
Lu Qi ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Molecular Weight ◽  
Endothelial Function ◽  
High Molecular Weight ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
High Molecular Weight Adiponectin ◽  
Article Type ◽  
Postdoctoral Fellowship

The authors and the journal apologise for an error in the funding section of this article published in 2010, vol 162, pp 281–288. The grant number that is listed as DK081923 is actually DK081913. The Funding section with the correct grant numbers is published in full below:FundingThis work was supported by the National Institute of Health (grants HL65582, HL60712, HL34594, DK58785, DK081913, DK79929, and DK58845), a discretionary grant from BIDMC, and a grant-in-aid by Tanita Corporation. Dr Hu is a recipient of the American Heart Association Established Investigator Award. Dr Sun is supported by a Postdoctoral Fellowship from the Unilever Corporate Research.

Effect of black tea consumption on brachial artery flow-mediated dilation and ischaemia–reperfusion in humans

2014 ◽  
Vol 39 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Tim H.A. Schreuder ◽  
Thijs M.H. Eijsvogels ◽  
Arno Greyling ◽  
Richard Draijer ◽  
Maria T.E. Hopman ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Brachial Artery ◽  
Black Tea ◽  
Hot Water ◽  
Flow Mediated Dilation ◽  
Tea Consumption ◽  
Ischaemia Reperfusion ◽  
Artery Flow ◽  
The Impact

Tea consumption is associated with reduced cardiovascular risk. Previous studies found that tea flavonoids work through direct effects on the vasculature, leading to dose-dependent improvements in endothelial function. Cardioprotective effects of regular tea consumption may relate to the prevention of endothelial ischaemia–reperfusion (IR) injury. Therefore, we examined the effect of black tea consumption on endothelial function and the ability of tea to prevent IR injury. In a randomized, crossover study, 20 healthy subjects underwent 7 days of tea consumption (3 cups per day) or abstinence from tea. We examined brachial artery (BA) endothelial function via flow-mediated dilation (FMD), using high resolution echo-Doppler, before and 90 min after tea or hot water consumption. Subsequently, we followed a 20-min ischaemia and 20-min reperfusion protocol of the BA after which we measured FMD to examine the potential of tea consumption to protect against IR injury. Tea consumption resulted in an immediate increase in FMD% (pre-consumption: 5.8 ± 2.5; post-consumption: 7.2 ± 3.2; p < 0.01), whilst no such change occurred after ingestion of hot water. The IR protocol resulted in a significant decrease in FMD (p < 0.005), which was also present after tea consumption (p < 0.001). This decline was accompanied by an increase in the post-IR baseline diameter. In conclusion, these data indicate that tea ingestion improves BA FMD. However, the impact of the IR protocol on FMD was not influenced by tea consumption. Therefore, the cardioprotective association of tea ingestion relates to a direct effect of tea on the endothelium in humans in vivo.

Daily Physical Activity and Brachial Artery Flow Mediated Dilation in Older Adults

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S20
Author(s):  
Michael A. Welsch ◽  
Devon A. Dobrosielski ◽  
Arturo A. Arce Esquivel ◽  
Ryan Russell ◽  
Eric Ravussin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Brachial Artery ◽  
Daily Physical Activity ◽  
Flow Mediated Dilation ◽  
Artery Flow
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