scholarly journals Impact of Socio-economic Status on IgE-mediated Food Allergy in Egyptian Children

2021 ◽  
Vol 147 (2) ◽  
pp. AB97
Author(s):  
Ahmed Elmazaly ◽  
Maged Refaat ◽  
Amal Assa'ad ◽  
Mohamed Farris ◽  
Osama Abdel-latif ◽  
...  
Keyword(s):  
Food Allergy ◽  
Economic Status ◽  
Socio Economic Status ◽  
Egyptian Children ◽  
Ige Mediated

ASSOCIATION OF STAT6 GENE SINGLE NUCLEOTIDE POLYMORPHISM WITH FOOD ALLERGY

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Zeinab Awad El-Sayed ◽  
Amira Fouad Elhattab ◽  
Mostafa Khaled Alamin
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Food Allergy ◽  
Positive Skin Prick Test ◽  
Target Tissue ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Group I ◽  
Egyptian Children ◽  
History Of ◽  
Ige Mediated

Abstract Background Food allergy (FA) may be IgE-mediated, non-IgE-mediated or mixed. Genetic predispositions result in dysregulation of the immune system and lead to FA when exposed to environmental triggers. The transcription factor STAT6 is activated by IL-4 and IL-13 and activates cytokine signaling in immune and target tissue cells; contributing in the pathogenesis of allergic disorders including FA. The rs324015 single nucleotide polymorphism (SNP) in the STAT6 gene was previously associated with nut and cow’s milk allergy. Objective to investigate the association of the rs324015 STAT6 gene SNP with food allergy. Patients and Methods After ethical committee approval and informed consent from the patients, this retrospective case control study was conducted on 100 Egyptian children divided into two groups. Group I consisted of 50 children with positive history of FA supported by positive skin prick test +/- oral food challenge and group II consisted of 50 healthy age-matched controls. Blood samples were collected and genotyped using Taqman® Realtime PCR assays. Results We found that the homozygous G genotype and G allele of rs324015 were significantly higher among food allergic subjects than controls. We report no effect of any specific genotype on the phenotype of allergic disease or reacting to a specific food more than others. Genotypes were also not related to disease severity, eosinophil counts, total IgE levels or a family history of atopic disease. Conclusion rs324015 STAT6 gene SNP may be involved in the pathophysiology of food allergy.

Oral Language Behavior of Older Cerebral Palsied Children

1964 ◽  
Vol 7 (4) ◽  
pp. 349-359 ◽  
Author(s):  
Russell J. Love
Keyword(s):  
Oral Language ◽  
Economic Status ◽  
Educational Background ◽  
Socio Economic Status ◽  
Language Behavior ◽  
Hearing Acuity

A battery of six tests assessing various aspects of receptive and expressive oral language was administered to 27 cerebral palsied children and controls matched on the variables of age, intelligence, sex, race, hearing acuity, socio-economic status, and similarity of educational background. Results indicated only minimal differences between groups. Signs of deviancy in language behavior often attributed to the cerebral palsied were not observed. Although previous investigators have suggested consistent language disturbances in the cerebral palsied, evidence for a disorder of comprehension and formulation of oral symobls was not found.

A study on the Relationship of the weight pattern with the socioeconomic status among adolescents school going children in an Indian Metropolitan City

2017 ◽  
Vol 3 (2) ◽  
pp. 320-323
Author(s):  
Samar Hossain ◽  
Sharma Priyanka ◽  
Talib Hossain ◽  
Surendra Mohan Mathur
Keyword(s):  
Socioeconomic Status ◽  
Socioeconomic Development ◽  
Economic Status ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Socio Economic Status ◽  
Obesity And Overweight ◽  
Prevalence Of Obesity ◽  
Development Levels

Objective: The last two decades have witnessed an increase in health care costs due to obesity and related issues among children and adolescents. Childhood obesity is a global phenomenon affecting all socio-economic groups, irrespective of age, sex or ethnicity. The study was done to find the the prevalence of obesity and overweight and their association with socioeconomic status (SES) and the risk factors. Materials and Methods: School based cross sectional study carried out over a period of 4 months in three schools of East Delhi. The study was carried out in 629 school children of 10–18 years of age and belonging to different socioeconomic statuses in schools in East Delhi. The obesity and overweight were considered using an updated body mass index reference. A pre-tested questionnaire was used to determine the Socio-economic status and life style factors. Results: The prevalence of overweight among children was higher in middle socioeconomic status groups as compared to high socioeconomic class in both boys and girls whereas the prevalence of obesity was higher in high Socio economic status group as compared to middle socioeconomic group. The prevalence of obesity as well as overweight in low SES group was the lowest as compared to other group. Conclusion: The findings of this study suggest that the prevalence of overweight and obesity varies remarkably with different socioeconomic development levels.

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