Childhood trauma history is linked to abnormal brain metabolism of non-medicated adult patients with major depressive disorder

2021 ◽  
Author(s):  
Haofei Miao ◽  
Shuming Zhong ◽  
Xuanjun Liu ◽  
Shunkai Lai ◽  
Jiali He ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Brain Metabolism ◽  
Adult Patients ◽  
Major Depressive ◽  
Trauma History ◽  
Abnormal Brain

scholarly journals A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Natalia Jaworska ◽  
Frank P. MacMaster ◽  
Ismael Gaxiola ◽  
Filomeno Cortese ◽  
Bradley Goodyear ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Cortical Thickness ◽  
Compensatory Mechanism ◽  
Adult Onset ◽  
Frontal Pole ◽  
Major Depressive ◽  
Trauma History ◽  
Pediatric Onset

Background. Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma. We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence.Methods. Adults with MDD (N=36) and controls (HC;N=18) underwent magnetic resonance imaging. Twenty patients had MDD onset<24 years of age (pediatric onset) and 16 had onset>25 years of age (adult onset). The MDD group was also subdivided into those with (N=12) and without (N=19) physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ). Cortical thickness was analyzed with FreeSurfer software.Results. Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD. The former was driven by the pediatric onset group and abuse history (independently), particularly in the right frontal pole. Inverse correlations existed between CTQ scores and frontal pole cortex thickness. A similar inverse relation existed with left inferior and right superior parietal cortex thickness. The superior temporal cortex tended to be thinner in pediatric versus adult onset groups with childhood abuse.Conclusions. This preliminary work suggests neural differences between pediatric and adult MDD onset. Trauma history also contributes to cytoarchitectural modulation. Thickened frontal pole cortices as a compensatory mechanism in MDD warrant evaluation.

Altered Brain Network Degree Centrality in Major Depressive Disorder via Electro-Acupuncture Stimulation at Baihui(gv20)

2021 ◽  
Author(s):  
Shasha Li ◽  
Ya Chen ◽  
Gaoxiong Duan ◽  
Yong Pang ◽  
Huimei Liu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Function ◽  
Brain Regions ◽  
Brain Network ◽  
Degree Centrality ◽  
Major Depressive ◽  
Acupuncture Stimulation ◽  
Therapeutic Mechanisms ◽  
Abnormal Brain

Abstract Background: Although the acupuncture treatment of major depressive disorder(MDD) has been recognized by the latest clinical practice guidelines of the American Academy of Internal Medicine, complex therapeutic mechanisms need further to clarify. The aim of the study is investigate whether the aberrant resting state brain network in MDD patients could be regulated by acupuncture at GV20 using functional magnetic resonance imaging(fMRI) combined with degree centrality(DC) method. Results: Compared to healthy subjects, MDD patients exhibited significantly aberrant DC in widely brain regions, including cortical(PFC, precuneus, temporal, insula) and sub-cortical (thalamus, putamen and caudate) structures. Furthermore, results showed that acupuncture at GV20 induced down-regulation the DC of abnormal brain regions in MDD patients. Conclusions: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the abnormal brain function state in MDD patients by using fMRI technique combined with DC analysis. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. Trial registration: ChiCTR, ChiCTR-IOR-15006357. Registered 05 May 2015, http://www.chictr.org.cn/showproj.aspx?proj=10922.

scholarly journals Childhood Adversity Impairs Theory of Mind Abilities in Adult Patients With Major Depressive Disorder

2019 ◽  
Vol 10 ◽  
Author(s):  
Maria Simon ◽  
Nándor Németh ◽  
Mónika Gálber ◽  
Elza Lakner ◽  
Eszter Csernela ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Theory Of Mind ◽  
Depressive Disorder ◽  
Childhood Adversity ◽  
Adult Patients ◽  
Major Depressive

scholarly journals Major depressive disorder is associated with subsequent adult-onset asthma: a population-based cohort study

2016 ◽  
Vol 26 (6) ◽  
pp. 664-671 ◽  
Author(s):  
T-C. Shen ◽  
C-L. Lin ◽  
C.H. Liao ◽  
C-C. Wei ◽  
F-C. Sung ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Proportional Hazards ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Adult Patients ◽  
Major Depressive ◽  
Significant Difference ◽  
Receptor Blockers

Aim.To examine the incidence of asthma in adult patients with major depressive disorder (MDD).Methods.From the National Health Insurance database of Taiwan, we identified 30 169 adult patients who were newly diagnosed with MDD between 2000 and 2010. Individuals without depression were randomly selected four times and frequency matched for sex, age and year of diagnosis. Both cohorts were followed-up for the occurrence of asthma up to the end of 2011. Adjusted hazard ratios (aHRs) of asthma were estimated using the Cox proportional hazards method.Results.The overall incidence of asthma was 1.91-fold higher in the MDD cohort than in the non-depression cohort (7.55 v. 3.96 per 1000 person-years), with an aHR of 1.66 (95% confidence interval (CI) 1.55–1.78). In both cohorts, the incidence of asthma was higher in patients and controls who were female, aged, with comorbidities and users of aspirin or beta-adrenergic receptor blockers. No significant difference was observed in the occurrence of asthma between patients with MDD treated with selective serotonin reuptake inhibitors (SSRIs) and those treated with non-SSRIs (SSRIs to non-SSRIs aHR = 1.03, 95% CI 0.91–1.17).Conclusion.Adult patients with MDD are at a higher risk of asthma than those without depression are.

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