P4-324: Aβ lowering after IV administration of a potent, cell-permeable small molecule BACE1 inhibitor

2006 ◽  
Vol 2 ◽  
pp. S612-S612
Author(s):  
Sethu Sankaranarayanan ◽  
Eric Price ◽  
Michelle Crouthamel ◽  
Guoxin Wu ◽  
Joan Ellis ◽  
...  
Keyword(s):  
Small Molecule ◽  
Bace1 Inhibitor

O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates

2008 ◽  
Vol 4 ◽  
pp. T114-T115
Author(s):  
Adam J. Simon ◽  
Marie Holihan ◽  
Guoxin Wu ◽  
Maria Michener ◽  
Diane Posavec ◽  
...  
Keyword(s):  
Oral Administration ◽  
Small Molecule ◽  
Bace1 Inhibitor

scholarly journals Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor

2017 ◽  
Vol 38 (15) ◽  
pp. 1260-1269 ◽  
Author(s):  
Christopher R. Ellis ◽  
Cheng-Chieh Tsai ◽  
Fang-Yu Lin ◽  
Jana Shen
Keyword(s):  
Small Molecule ◽  
Cathepsin D ◽  
Conformational Dynamics ◽  
Bace1 Inhibitor

A privileged ternary blend enabling non-fullerene organic photovoltaics with over 14% efficiency

2020 ◽  
Vol 8 (43) ◽  
pp. 15135-15141
Author(s):  
Jing Yan ◽  
Yuan-Qiu-Qiang Yi ◽  
Jianqi Zhang ◽  
Huanran Feng ◽  
Yanfeng Ma ◽  
...  
Keyword(s):  
Small Molecule ◽  
Organic Photovoltaics ◽  
Power Conversion ◽  
Ternary Blend ◽  
Conversion Efficiencies

Two non-fullerene small molecule acceptors, NT-4F and NT-4Cl, were designed and synthesized. Power conversion efficiencies of 11.44% and 14.55% were achieved for NT-4Cl-based binary and ternary devices, respectively.

The small-molecule antibiotics pipeline: 2014–2018

2019 ◽  
Vol 18 (10) ◽  
pp. 739-739 ◽  
Author(s):  
Cara Lepore ◽  
Lynn Silver ◽  
Ursula Theuretzbacher ◽  
Joe Thomas ◽  
David Visi
Keyword(s):  
Small Molecule

Anisotropic forces in small molecule crystals

1985 ◽  
Vol 82 ◽  
pp. 91-97 ◽  
Author(s):  
H. Bonadeo ◽  
E. Burgos
Keyword(s):  
Small Molecule

P157 FBXO3-FBXL2 AXIS MODULATORS AS A NOVEL CLASS OF ORAL SMALL MOLECULE COMPOUNDS FOR THE TREATMENT OF CROHN’S DISEASE

2020 ◽  
Vol 158 (3) ◽  
pp. S9-S10
Author(s):  
Franca Angeli ◽  
Russell Wyborski ◽  
Bill Chen ◽  
Rama Mallampalli ◽  
Michael Lark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Small Molecule

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor
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