Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor

TAp73α Increases p53 Tumor Suppressor Activity in Thyroid Cancer Cells via the Inhibition of Mdm2-Mediated Degradation

2008 ◽  
Vol 6 (1) ◽  
pp. 64-77 ◽  
Author(s):  
Roberta Malaguarnera ◽  
Veronica Vella ◽  
Giuseppe Pandini ◽  
Mariangela Sanfilippo ◽  
Vincenzo Pezzino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Thyroid Cancer Cells

293 DDX31 REGULATES P53 TUMOR SUPPRESSOR ACTIVITY THROUGH ITS INTERACTION WITH NPM1 IN RENAL CELL CARCINOMAS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Tomoya Fukawa ◽  
Taisuke Matsuo ◽  
Masahiko Takemura ◽  
Yasuyo Yamamoto ◽  
Kunihisa Yamaguchi ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Cell ◽  
Renal Cell Carcinomas ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

10.1038/ng894 ◽  
2002 ◽  
Vol 31 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Dmitry V. Bulavin ◽  
Oleg N. Demidov ◽  
Shin'ichi Saito ◽  
Paivikki Kauraniemi ◽  
Crissy Phillips ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Tumors ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity

scholarly journals Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions

Oncogene ◽  
2009 ◽  
Vol 28 (48) ◽  
pp. 4284-4294 ◽  
Author(s):  
D Walerych ◽  
M B Olszewski ◽  
M Gutkowska ◽  
A Helwak ◽  
M Zylicz ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Molecular Chaperones ◽  
Stress Conditions ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity
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