P3-201: Spatial heterogeneity of patterns of cortical amyloid deposition in healthy aging and its relationship to memory decline

2012 ◽  
Vol 8 (4S_Part_14) ◽  
pp. P529-P530
Author(s):  
Rachel Yotter ◽  
Jimit Doshi ◽  
Vanessa Clark ◽  
Jitka Sojkova ◽  
Yungui Zhou ◽  
...  
2012 ◽  
Vol 8 (4S_Part_2) ◽  
pp. P49-P50
Author(s):  
Rachel Yotter ◽  
Jimit Doshi ◽  
Vanessa Clark ◽  
Jitka Sojkova ◽  
Yungui Zhou ◽  
...  

2021 ◽  
Vol 18 ◽  
Author(s):  
Ming-Liang Wang ◽  
Meng-Meng Yu ◽  
Wen-Bin Li ◽  
Yue-Hua Li

Background: White matter (WM) beta-amyloid uptake has been used as a reference region to calculate the cortical standard uptake value ratio (SUVr). However, white matter hyperintensities (WMH) may have an influence on WM beta-amyloid uptake. Our study aimed to investigate the associations between WMH and WM beta-amyloid deposition in cognitively unimpaired elderly. Method: Data from 83 cognitively unimpaired individuals in the Alzheimer’s Disease Neuroimag- ing Initiative (ADNI) dataset were analyzed. All participants had complete baseline and four-year follow-up information about WMH volume, WM 18F-AV-45 SUVr, and cognitive function, includ- ing ADNI-Memory (ADNI-Mem) and ADNI-Executive function (ADNI-EF) scores. Cross-sectional and longitudinal linear regression analyses were used to determine the associations between WMH and WM SUVr and cognitive measures. Results: Lower WM 18F-AV-45 SUVr at baseline was associated with younger age (β=0.01, P=0.037) and larger WMH volume (β=-0.049, P=0.048). The longitudinal analysis found an annual increase in WM 18F-AV-45 SUVr was associated with an annual decrease in WMH volume (β=-0.016, P=0.041). An annual decrease in the ADNI-Mem score was associated with an annual increase in WMH volume (β=-0.070, P=0.001), an annual decrease in WM 18F-AV-45 SUVr (β=0.559, P=0.030), and fewer years of education (β=0.011, P=0.044). There was no significant as- sociation between WM 18F-AV-45 SUVr and ADNI-EF (P>0.05). Conclusions: Reduced beta-amyloid deposition in WM was associated with higher WMH load and memory decline in cognitively unimpaired elderly. WMH volume should be considered when WM 18F-AV-45 SUVr is used as a reference for evaluating cortical 18F-AV-45 SUVr.


2020 ◽  
Vol 31 (11) ◽  
pp. 1386-1395
Author(s):  
Emily F. Hittner ◽  
Jacquelyn E. Stephens ◽  
Nicholas A. Turiano ◽  
Denis Gerstorf ◽  
Margie E. Lachman ◽  
...  

Memory decline is a concern for aging populations across the globe. Positive affect plays an important role in healthy aging, but its link with memory decline has remained unclear. In the present study, we examined associations between positive affect (i.e., feeling enthusiastic, attentive, proud, active) and memory (i.e., immediate and delayed recall), drawing from a 9-year longitudinal study of a national sample of 991 middle-age and older U.S. adults. Results revealed that positive affect was associated with less memory decline across 9 years when analyses controlled for age, gender, education, depression, negative affect, and extraversion. Findings generalized across another measure that assessed additional facets of positive affect, across different (but not all) facets of positive affect and memory, and across age, gender, and education; findings did not emerge for negative affect. Reverse longitudinal associations between memory and positive affect were not significant. Possible pathways linking positive affect and memory functioning are discussed.


2013 ◽  
Vol 9 ◽  
pp. P695-P696
Author(s):  
Rachel Yotter ◽  
Jimit Doshi ◽  
Bilwaj Gaonkar ◽  
Vanessa Clark ◽  
Jitka Sojkova ◽  
...  

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Cristina Solé‐Padullés ◽  
Lídia Vaqué‐Alcázar ◽  
Kilian Abellaneda‐Pérez ◽  
Emilio Ros ◽  
David Bartres‐Faz

Sign in / Sign up

Export Citation Format

Share Document