scholarly journals The relationship of functional hippocampal activity, amyloid deposition, and longitudinal memory decline to memory complaints in cognitively healthy older adults

2021 ◽  
Author(s):  
Xi Chen ◽  
Michelle E. Farrell ◽  
Melissa M. Rundle ◽  
Micaela Y. Chan ◽  
William Moore ◽  
...  
Keyword(s):  
Older Adults ◽  
Amyloid Deposition ◽  
Memory Decline ◽  
Healthy Older Adults ◽  
Memory Complaints ◽  
Hippocampal Activity ◽  
Relationship Of ◽  
The Relationship

scholarly journals The Relationship of Aspiration Status With Tongue and Handgrip Strength in Healthy Older Adults

2011 ◽  
Vol 66A (4) ◽  
pp. 452-458 ◽  
Author(s):  
S. G. Butler ◽  
A. Stuart ◽  
X. Leng ◽  
E. Wilhelm ◽  
C. Rees ◽  
...  
Keyword(s):  
Older Adults ◽  
Handgrip Strength ◽  
Healthy Older Adults ◽  
Relationship Of ◽  
The Relationship

scholarly journals Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Alexandra N Trelle ◽  
Valerie A Carr ◽  
Scott A Guerin ◽  
Monica K Thieu ◽  
Manasi Jayakumar ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Memory Decline ◽  
Cognitively Normal ◽  
Pattern Completion ◽  
Age Related ◽  
Hippocampal Activity ◽  
Fundamental Process ◽  
Individual Memory ◽  
The Relationship

Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstatement and its relationship to memory behaviour. Moreover, individual differences in the strength of hippocampal activity and cortical reinstatement explained unique variance in performance across multiple assays of episodic memory. These results indicate that fMRI indices of hippocampal pattern completion explain within- and across-individual memory variability in older adults.

scholarly journals Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study

2014 ◽  
Vol 204 (5) ◽  
pp. 400-401 ◽  
Author(s):  
Robert H. Pietrzak ◽  
J. Cobb Scott ◽  
Alexander Neumeister ◽  
Yen Ying Lim ◽  
David Ames ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Memory Function ◽  
Beta Amyloid ◽  
Anxiety Symptoms ◽  
Memory Decline ◽  
Healthy Older Adults ◽  
Observational Cohort ◽  
Using Data ◽  
The Relationship

SummaryAlthough beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.

scholarly journals The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Marcela Kitaigorodsky ◽  
Elizabeth Crocco ◽  
Rosie E. Curiel‐Cid ◽  
Giselle Leal ◽  
Diane Zheng ◽  
...  
Keyword(s):  
Older Adults ◽  
Healthy Older Adults ◽  
Relationship Of ◽  
The Relationship

Semantic integration declines independently of working memory in aging

2019 ◽  
Vol 40 (6) ◽  
pp. 1481-1494
Author(s):  
Zude Zhu ◽  
Suiping Wang ◽  
Nannan Xu ◽  
Mengya Li ◽  
Yiming Yang
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Event Related Potentials ◽  
Semantic Integration ◽  
N400 Effect ◽  
Younger Adults ◽  
Memory Decline ◽  
Healthy Older Adults ◽  
Related Potentials ◽  
The Relationship

AbstractSemantic integration and working memory both decline with age. However, it remains unclear whether the semantic integration decline is independent of working memory decline or whether it can be solely explained by the latter factor. In this event-related potentials experiment, 43 younger adults and 43 cognitively healthy older adults read semantically congruent and incongruent sentences. After controlling for working memory, behavioral accuracy was significantly lower in the older adults than in the younger adults. In addition, the semantic integration related N400 effect (incongruent vs. congruent) for correct trials was apparent in the whole brain in the younger adults but restricted to the posterior region in the older adults. The results clarify the relationship between working memory and semantic integration, and clearly demonstrate that semantic integration decline is independent of working memory decline during aging.

scholarly journals Normative Data for a Tablet-Based Dual-Task Assessment in Healthy Older Adults

2020 ◽  
Author(s):  
Maxime Lussier ◽  
Kathia Saillant ◽  
Tudor Vrinceanu ◽  
Carol Hudon ◽  
Louis Bherer
Keyword(s):  
Older Adults ◽  
Dual Task ◽  
Normative Data ◽  
Healthy Older Adults ◽  
Highly Educated ◽  
Coefficient Of Variability ◽  
French And English ◽  
Task Assessment ◽  
English Speaking ◽  
The Relationship

Abstract Objective The objective of this study is to provide normative data for a tablet-based dual-task assessment in older adults without cognitive deficits. Method In total, 264 participants aged between 60 and 90 years, French and English-speaking, were asked to perform two discrimination tasks, alone and concurrently. The participants had to answer as fast as possible to one or two images appearing in the center of the tablet by pressing to the corresponding buttons. Normative data are provided for reaction time (RT), coefficient of variation, and accuracy. Analyses of variance were performed by trial types (single-pure, single-mixed, dual-mixed), and linear regressions assessed the relationship between performance and sociodemographic characteristics. Results The participants were highly educated and a large proportion of them were women (73.9%). The accuracy on the task was very high across all blocks. RT data revealed both a task-set cost and a dual-task cost between the blocks. Age was associated with slower RT and with higher coefficient of variability. Men were significantly slower on dual-mixed trials, but their coefficient of variability was lower on single-pure trials. Education was not associated with performance. Conclusions This study provides normative data for a tablet-based dual-task assessment in older adults without cognitive impairment, which was lacking. All participants completed the task with good accuracy in less than 15 minutes and thus, the task is transferable to clinical and research settings.

scholarly journals The relationship between memory complaints and age in normal aging

2009 ◽  
Vol 3 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Thaís Bento Lima-Silva ◽  
Mônica Sanches Yassuda
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Digit Span ◽  
Normal Aging ◽  
Screening Tests ◽  
Memory Complaint ◽  
Memory Complaints ◽  
The Impact ◽  
The Relationship

Abstract Normal aging can be characterized by a gradual decline in some cognitive functions, such as memory. Memory complaints are common among older adults, and may indicate depression, anxiety, or cognitive decline. Objectives: To investigate the association between memory complaints and age in cognitively unimpaired older adults, and the relationship between memory complaints and memory performance. Methods: Cognitive screening tests as well as memory complaint questionnaires validated for the Brazilian population were used: the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Memory Complaint Questionnaire (MAC-Q), Memory test of 18 pictures, Forward and Backward Digit Span (WAIS-III). Fifty seven regular members of the SESC social club participated (50 women), having a mean age of 71.4 years, and 4 to 8 years of education - 34 from 4 to 7 years and 23 with 8 years of education. Results: Results revealed no significant association between cognitive complaints and age or cognitive performance. Older participants in this sample did not show worse performance or a higher level of complaints. There was no significant association between age and GDS scores. Conclusions: The studied sample constitutes a particular group of older adults whose participation in activities may be protecting them from cognitive decline, thus highlighting the impact of lifestyle on cognitive performance during the aging process.

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