P1-386: Cross-species analysis of cerebrospinal fluid (CSF) beta-amyloid reductions by the BACE1 inhibitor PF-05297909 indicates species differences in PK/PD relationships: Relevance to clinical translation

2013 ◽  
Vol 9 ◽  
pp. P300-P300
Author(s):  
Eva Hajos-Korcsok ◽  
Charles Nolan ◽  
Ashley Robshaw ◽  
Curt Christoffersen ◽  
JinHua Liu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Species Differences ◽  
Beta Amyloid ◽  
Clinical Translation ◽  
Bace1 Inhibitor ◽  
Species Analysis

Species Differences in Hepatocyte-Directed Gene Transfer: Implications for Clinical Translation

2009 ◽  
Vol 9 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Frank Jacobs ◽  
Yingmei Feng ◽  
Eline Craeyveld ◽  
Joke Lievens ◽  
Jan Snoeys ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Species Differences ◽  
Clinical Translation

BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides

2017 ◽  
Vol 57 (11) ◽  
pp. 1460-1471 ◽  
Author(s):  
Kei Sakamoto ◽  
Shunji Matsuki ◽  
Kyoko Matsuguma ◽  
Tatsuya Yoshihara ◽  
Naoki Uchida ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Aβ Peptides ◽  
Bace1 Inhibitor ◽  
Japanese Subjects

O2-03-05: Beta-amyloid-17 is a major beta-amyloid fragment isoform in cerebrospinal fluid and blood that shows diagnostic value

2012 ◽  
Vol 8 (4S_Part_7) ◽  
pp. P240-P240 ◽  
Author(s):  
Virginia Pérez ◽  
Leticia Sarasa ◽  
Jose A. Allue ◽  
Diego Casabona ◽  
Maria Montanes ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Beta Amyloid ◽  
Diagnostic Value

scholarly journals Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer’s disease

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Umesh Gangishetti ◽  
J. Christina Howell ◽  
Richard J. Perrin ◽  
Natalia Louneva ◽  
Kelly D. Watts ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Beta Amyloid

P1-331: Cerebrospinal Fluid Beta-Amyloid 40 and 42 Quantitation Using a Novel Stabilization Technique

2016 ◽  
Vol 12 ◽  
pp. P555-P555
Author(s):  
Diana Tran ◽  
Darren M. Weber ◽  
Scott Goldman ◽  
Brian Sansoucy ◽  
Amanda Albi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Beta Amyloid ◽  
Stabilization Technique

scholarly journals Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140966 ◽  
Author(s):  
Torkil Benterud ◽  
Leonid Pankratov ◽  
Rønnaug Solberg ◽  
Nils Bolstad ◽  
Anders Skinningsrud ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cerebrospinal Fluid ◽  
Perinatal Asphyxia ◽  
Beta Amyloid ◽  
Newborn Pigs

P4-061: Distribution of beta-amyloid peptides in leptomeningeal amyloid deposits and cerebrospinal fluid in patients with Alzheimer's disease: A mirror image

2012 ◽  
Vol 8 (4S_Part_18) ◽  
pp. P655-P656
Author(s):  
Marcella Catania ◽  
Giuseppe Di Fede ◽  
Valentina Albertini ◽  
Luisa Benussi ◽  
Giuliano Binetti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Beta Amyloid ◽  
Mirror Image ◽  
Amyloid Peptides ◽  
Amyloid Deposits
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