P3-092: Plasma and cerebrospinal fluid amyloid-b levels in late-life depression: A systematic review and meta-analysis

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P655-P655
Author(s):  
Kenia Kelly Fiaux do Nascimento ◽  
Kelly Silva Pereira ◽  
Breno SatlerS. Diniz ◽  
Leandro F. Malloy-Diniz ◽  
Meryl Butters
Keyword(s):  
Systematic Review ◽  
Cerebrospinal Fluid ◽  
Meta Analysis ◽  
Late Life ◽  
Late Life Depression

scholarly journals Plasma and cerebrospinal fluid amyloid-β levels in late-life depression: A systematic review and meta-analysis

2015 ◽  
Vol 69 ◽  
pp. 35-41 ◽  
Author(s):  
Kenia Kelly Fiaux do Nascimento ◽  
Kelly P. Silva ◽  
Leandro F. Malloy-Diniz ◽  
Meryl A. Butters ◽  
Breno S. Diniz
Keyword(s):  
Systematic Review ◽  
Cerebrospinal Fluid ◽  
Meta Analysis ◽  
Amyloid Β ◽  
Late Life ◽  
Late Life Depression

Tau in Late-Life Depression: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 54 (2) ◽  
pp. 615-633 ◽  
Author(s):  
Eric E. Brown ◽  
Yusuke Iwata ◽  
Jun Ku Chung ◽  
Philip Gerretsen ◽  
Ariel Graff-Guerrero
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Late Life ◽  
Late Life Depression

Systematic review and meta-analysis of genetic studies of late-life depression

2017 ◽  
Vol 75 ◽  
pp. 129-139 ◽  
Author(s):  
Ruby S.M. Tsang ◽  
Karen A. Mather ◽  
Perminder S. Sachdev ◽  
Simone Reppermund
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Late Life ◽  
Late Life Depression ◽  
Genetic Studies

scholarly journals Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

2013 ◽  
Vol 202 (5) ◽  
pp. 329-335 ◽  
Author(s):  
Breno S. Diniz ◽  
Meryl A. Butters ◽  
Steven M. Albert ◽  
Mary Amanda Dew ◽  
Charles F. Reynolds
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Meta Analysis ◽  
Significant Risk ◽  
Late Life ◽  
Population Based ◽  
Late Life Depression ◽  
Increased Risk

BackgroundLate-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia.AimsTo conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies.MethodA total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression.ResultsLate-life depression was associated with a significant risk of all-cause dementia (1.85, 95% CI 1.67-2.04, P< 0.001), Alzheimer's disease (1.65, 95% CI 1.42-1.92, P<0.001) and vascular dementia (2.52, 95% CI 1.77-3.59, P<0.001). Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P=0.03).ConclusionsLate-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease.

Diffusion tensor imaging studies in late-life depression: systematic review and meta-analysis

2014 ◽  
Vol 29 (12) ◽  
pp. 1173-1184 ◽  
Author(s):  
Ming-Ching Wen ◽  
David C. Steffens ◽  
Mei-Kuang Chen ◽  
Nur Hani Zainal
Keyword(s):  
Systematic Review ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Late Life ◽  
Late Life Depression ◽  
Imaging Studies

scholarly journals The association of late-life depression with all-cause and cardiovascular mortality among community-dwelling older adults: systematic review and meta-analysis

2019 ◽  
Vol 215 (2) ◽  
pp. 449-455 ◽  
Author(s):  
Jingkai Wei ◽  
Ruixue Hou ◽  
Xiaotao Zhang ◽  
Huiwen Xu ◽  
Liyang Xie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cardiovascular Mortality ◽  
Meta Analysis ◽  
Late Life ◽  
Community Dwelling ◽  
Late Life Depression ◽  
Prospective Cohort Studies ◽  
Community Dwelling Older Adults

BackgroundLate-life depression has become an important public health problem. Available evidence suggests that late-life depression is associated with all-cause and cardiovascular mortality among older adults living in the community, although the associations have not been comprehensively reviewed and quantified.AimTo estimate the pooled association of late-life depression with all-cause and cardiovascular mortality among community-dwelling older adults.MethodWe conducted a systematic review and meta-analysis of prospective cohort studies that examine the associations of late-life depression with all-cause and cardiovascular mortality in community settings.ResultsA total of 61 prospective cohort studies from 53 cohorts with 198 589 participants were included in the systematic review and meta-analysis. A total of 49 cohorts reported all-cause mortality and 15 cohorts reported cardiovascular mortality. Late-life depression was associated with increased risk of all-cause (risk ratio 1.34; 95% CI 1.27, 1.42) and cardiovascular mortality (risk ratio 1.31; 95% CI 1.20, 1.43). There was heterogeneity in results across studies and the magnitude of associations differed by age, gender, study location, follow-up duration and methods used to assess depression. The associations existed in different subgroups by age, gender, regions of studies, follow-up periods and assessment methods of late-life depression.ConclusionLate-life depression is associated with higher risk of both all-cause and cardiovascular mortality among community-dwelling elderly people. Future studies need to test the effectiveness of preventing depression among older adults as a way of reducing mortality in this population. Optimal treatment of late-life depression and its impact on mortality require further investigation.Declaration of interestNone.

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