P2-170: Suppression of Different Genes by Irna in a DROSOPHILA Model and their Possible Relation to the Pathology of Alzheimer’s Disease: Bottom-Up Proteomics of Alzheimer’s Disease Brains and Validation in DROSOPHILA Models

2016 ◽  
Vol 12 ◽  
pp. P681-P681
Author(s):  
Benito D. Minjarez ◽  
Yury Rodriguez-Yañez ◽  
Jesse Haramati ◽  
Juan Pedro Luna-Arias ◽  
Diego E. Rincon-Limas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bottom Up ◽  
Drosophila Model ◽  
Drosophila Models

Genetic Modifiers of Tauopathy in Drosophila

Genetics ◽  
2003 ◽  
Vol 165 (3) ◽  
pp. 1233-1242
Author(s):  
Joshua M Shulman ◽  
Mel B Feany
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Mechanisms ◽  
Genetic Modifier ◽  
Genetic Modifiers ◽  
Protein Tau ◽  
Major Class ◽  
Drosophila Model ◽  
Tau Kinases

Abstract In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in the tau gene cause familial frontotemporal dementia. To investigate the molecular mechanisms responsible for Tau-induced neurodegeneration, we conducted a genetic modifier screen in a Drosophila model of tauopathy. Kinases and phosphatases comprised the major class of modifiers recovered, and several candidate Tau kinases were similarly shown to enhance Tau toxicity in vivo. Despite some clinical and pathological similarities among neurodegenerative disorders, a direct comparison of modifiers between different Drosophila disease models revealed that the genetic pathways controlling Tau and polyglutamine toxicity are largely distinct. Our results demonstrate that kinases and phosphatases control Tau-induced neurodegeneration and have important implications for the development of therapies in Alzheimer's disease and related disorders.

scholarly journals Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

2017 ◽  
Vol 2 ◽  
pp. 15-26 ◽  
Author(s):  
Stephane Dissel ◽  
Markus Klose ◽  
Jeff Donlea ◽  
Lijuan Cao ◽  
Denis English ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Deficits ◽  
Underlying Pathology ◽  
Drosophila Models

scholarly journals GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 99274-99283 ◽  
Author(s):  
Wai Yin Vivien Chiu ◽  
Alex Chun Koon ◽  
Jacky Chi Ki Ngo ◽  
Ho Yin Edwin Chan ◽  
Kwok-Fai Lau
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model

scholarly journals Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8191 ◽  
Author(s):  
Svetlana Sarantseva ◽  
Svetlana Timoshenko ◽  
Olga Bolshakova ◽  
Eugenia Karaseva ◽  
Dmitry Rodin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Cognitive Functions ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model ◽  
Transgenic Drosophila

scholarly journals Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8310 ◽  
Author(s):  
Kanae Iijima-Ando ◽  
Stephen A. Hearn ◽  
Christopher Shenton ◽  
Anthony Gatt ◽  
LiJuan Zhao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Dysfunction ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model

scholarly journals Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

PLoS Genetics ◽  
2012 ◽  
Vol 8 (4) ◽  
pp. e1002683 ◽  
Author(s):  
Minglin Lang ◽  
Lei Wang ◽  
Qiangwang Fan ◽  
Guiran Xiao ◽  
Xiaoxi Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

2010 ◽  
Vol 223 (2) ◽  
pp. 401-409 ◽  
Author(s):  
James Folwell ◽  
Catherine M. Cowan ◽  
Kiren K. Ubhi ◽  
Hassan Shiabh ◽  
Tracey A. Newman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Dysfunction ◽  
Model Of Alzheimer’S Disease ◽  
Drosophila Model ◽  
Tau Expression
Sign in / Sign up

Export Citation Format

Share Document