[IC-P-070]: ASSOCIATIONS BETWEEN SOCIAL NETWORK CHARACTERISTICS AND CORTICAL THICKNESS AND HIPPOCAMPAL VOLUME IN COGNITIVELY NORMAL SUBJECTS

2017 ◽  
Vol 13 (7S_Part_1) ◽  
pp. P58-P59
Author(s):  
Brea L. Perry ◽  
Evan Finley ◽  
Shannon L. Risacher ◽  
Eileen F. Tallman ◽  
Liana G. Apostolova ◽  
...  
Keyword(s):  
Social Network ◽  
Cortical Thickness ◽  
Normal Subjects ◽  
Hippocampal Volume ◽  
Cognitively Normal ◽  
Network Characteristics ◽  
Cognitively Normal Subjects

[P3-530]: ASSOCIATIONS BETWEEN SOCIAL NETWORK CHARACTERISTICS AND CORTICAL THICKNESS AND HIPPOCAMPAL VOLUME IN COGNITIVELY NORMAL SUBJECTS

2017 ◽  
Vol 13 (7S_Part_24) ◽  
pp. P1181-P1181
Author(s):  
Brea L. Perry ◽  
Evan Finley ◽  
Shannon L. Risacher ◽  
Eileen F. Tallman ◽  
Liana G. Apostolova ◽  
...  
Keyword(s):  
Social Network ◽  
Cortical Thickness ◽  
Normal Subjects ◽  
Hippocampal Volume ◽  
Cognitively Normal ◽  
Network Characteristics ◽  
Cognitively Normal Subjects

P3-231: ASSOCIATION OF BODY FAT PERCENTAGE AND WAIST-HIP RATIO WITH BRAIN CORTICAL THICKNESS IN 1,777 COGNITIVELY NORMAL SUBJECTS

2014 ◽  
Vol 10 ◽  
pp. P715-P716
Author(s):  
Hee-Jin Kim ◽  
Sang Won Seo ◽  
Seun Jeon ◽  
Mira Kang ◽  
Yeo Jin Kim ◽  
...  
Keyword(s):  
Body Fat ◽  
Cortical Thickness ◽  
Normal Subjects ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Cognitively Normal ◽  
Waist Hip Ratio ◽  
Cognitively Normal Subjects

Elevated neurofilament light chain in plasma is associated with reduced right hippocampal and amygdala volume in Alzheimer's patients

2020 ◽  
Author(s):  
Wei Li ◽  
Ling Yue ◽  
Ye Wu ◽  
Lin Sun ◽  
Shifu Xiao
Keyword(s):  
Single Molecule ◽  
Normal Subjects ◽  
Hippocampal Volume ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Cognitively Normal ◽  
Amci Group ◽  
Amygdala Volume ◽  
Cognitively Normal Subjects ◽  
Amnesic Mild Cognitive Impairment

Abstract Background Plasma neurofilament light (NfL) levels have been considered as an especially promising biomarker for dementia, however, the mechanism of NfL regulating cognition is not very clear. Methods 43 amnesic mild cognitive impairment(aMCI), 35 Alzheimer’s disease (AD) and 30 cognitively normal subjects were recruited. Plasma NfL levels were examined by the Single Molecule array (Simoa) technique; the volumes of the hippocampus and amygdala were calculated and compared by T1-weighted MRI; and cognitive function was assessed by the Beijing version of the Montreal Cognitive Assessment (MoCA) Results Our results showed significantly increased plasma NfL levels in AD group (29.42 pg/ml) compared to aMCI(15.92 pg/ml) group and normal (12.85 pg/ml) group (both p < 0.001), while there was no statistical difference (p>0.05) between aMCI group and normal group. And the results of partial correlation analysis showed that plasma NfL levels were negatively correlated (p<0.05)with MoCA total score (r=-0.415, p=0.013), right hippocampal volume(r=-0.335,p=0.036) and right amygdala volume(r=-0.337, p=0.048). Conclusions NfL in plasma of AD patients is significantly increased, and the protein is related to atrophy of right hippocampus and right amygdala.

scholarly journals SNIPE score can capture prodromal Alzheimer’s in cognitively normal subjects

2019 ◽  
Author(s):  
Azar Zandifar ◽  
Vladimir Fonov ◽  
Olivier Potvin ◽  
Simon Duchesne ◽  
D. Louis Collins ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
High Sensitivity ◽  
Normal Subjects ◽  
Hippocampal Volume ◽  
Cognitively Normal ◽  
Age Related ◽  
Brain Changes ◽  
The Difference ◽  
Cognitively Normal Subjects

AbstractCapturing early changes in the brain related to Alzheimer’s disease may lead to models that successfully predict cognitive decline and the eventual onset of dementia, well ahead of onset of clinical symptoms. In this study we used both hippocampal volume and our hippocampal driven SNIPE score to show which marker better captures Alzheimer’s related changes in a large dataset of normal controls (N=515) from the ADNI study, comparing controls that remain cognitively stable and controls that progress to either MCI or Alzheimer’s dementia during 10 years of follow-up (median follow-up: 30 months). We measured hippocampal volume and SNIPE score and found that the effect size to differentiate between stable and progressor groups was significantly larger for SNIPE score than for volume. Our results also show that there is a significant age-related difference between groups for both markers, and the difference is greater with the SNIPE score. Our experiments show that considering high sensitivity of our SNIPE score regarding to early AD-related brain changes, this marker is a better candidate in comparison to hippocampal volume for predicting the future onset of dementia.

Social network characteristics moderate associations between cortical thickness and cognitive functioning in older adults

2021 ◽  
Author(s):  
Neika Sharifian ◽  
Afsara B. Zaheed ◽  
Emily P. Morris ◽  
Ketlyne Sol ◽  
Jennifer J. Manly ◽  
...  
Keyword(s):  
Older Adults ◽  
Social Network ◽  
Cognitive Functioning ◽  
Cortical Thickness ◽  
Network Characteristics

scholarly journals Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects

2014 ◽  
Vol 35 (2) ◽  
pp. 357-364 ◽  
Author(s):  
Steven P. Millard ◽  
Franziska Lutz ◽  
Ge Li ◽  
Douglas R. Galasko ◽  
Martin R. Farlow ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Normal Subjects ◽  
Cognitively Normal ◽  
Cognitively Normal Subjects

Tau PET Distributional Pattern in AD Patients with Visuospatial Dysfunction

2019 ◽  
Vol 16 (11) ◽  
pp. 1055-1062
Author(s):  
Xi Sun ◽  
Binbin Nie ◽  
Shujun Zhao ◽  
Qian Chen ◽  
Panlong Li ◽  
...  
Keyword(s):  
Temporal Cortex ◽  
Cingulate Cortex ◽  
Normal Subjects ◽  
Neural Correlates ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Distributional Pattern ◽  
Cognitively Normal ◽  
Posterior Cingulate ◽  
Cognitively Normal Subjects

Background: Visuospatial dysfunction is one predominant symptom in many atypical Alzheimer’s disease (AD) patients, however, until now its neural correlates still remain unclear. For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits. Objective: We investigated the brain regions particularly affected by tau accumulation in patients with visuospatial dysfunction to explore its neural correlates. Methods: Using 18F-AV-1451 tau positron emission tomography (PET), voxel-wise two-sample t-tests were performed between AD patients with obvious visuospatial dysfunction (VS-AD) and cognitively normal subjects, AD patients with little-to-no visuospatial dysfunction (non VS-AD) and cognitively normal subjects, respectively. Results: Results showed increased tau accumulations mainly located in occipitoparietal cortex, posterior cingulate cortex, precuneus, inferior and medial temporal cortex in VS-AD patients, while increased tau accumulations mainly occurred in the inferior and medial temporal cortex in non VS-AD patients. Conclusion: These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD.

Plasma Glucose Levels Affect Cerebral 18F-FDG Distribution in Cognitively Normal Subjects With Diabetes

2016 ◽  
Vol 41 (6) ◽  
pp. e274-e280 ◽  
Author(s):  
Kenji Ishibashi ◽  
Airin Onishi ◽  
Yoshinori Fujiwara ◽  
Kiichi Ishiwata ◽  
Kenji Ishii
Keyword(s):  
Plasma Glucose ◽  
Normal Subjects ◽  
Cognitively Normal ◽  
Glucose Levels ◽  
18F Fdg ◽  
Cognitively Normal Subjects
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