PREMORBID COGNITION, CHILDHOOD SOCIOECONOMIC STATUS AND LATE-LIFE BURDEN OF CEREBRAL SMALL VESSEL DISEASE: AN ANALYSIS OF 3 LONGITUDINAL COHORT STUDIES

2017 ◽  
Vol 13 (7) ◽  
pp. P566-P567
Author(s):  
Ellen V. Backhouse ◽  
Susan D. Shenkin ◽  
Andrew McIntosh ◽  
Ian Deary ◽  
Mark Bastin ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cohort Studies ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Longitudinal Cohort ◽  
Vessel Disease ◽  
Childhood Socioeconomic Status

scholarly journals Cerebral Small‐Vessel Disease and Risk of Incidence of Depression: A Meta‐Analysis of Longitudinal Cohort Studies

2020 ◽  
Vol 9 (15) ◽  
Author(s):  
Yuanyuan Fang ◽  
Tingting Qin ◽  
Wenhua Liu ◽  
Lusen Ran ◽  
Yuan Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Studies ◽  
Small Vessel Disease ◽  
Meta Analysis ◽  
Cerebral Atrophy ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Longitudinal Cohort ◽  
Vessel Disease

Background Results of several longitudinal cohort studies suggested an association between cerebral small‐vessel disease and depression. Therefore, we performed a meta‐analysis to explore whether cerebral small‐vessel disease imparts increased risk for incident depression. Methods and Results We searched prospective cohort studies relevant to the relationship between cerebral small‐vessel disease and incident depression published through September 6, 2019, which yielded 16 cohort studies for meta‐analysis based on the relative odds ratio (OR) calculated with fixed‐ and random‐effect models. Baseline white matter hyperintensities (WMHs) (pooled OR, 1.37; 95% CI, 1.14–1.65), enlarged perivascular spaces (pooled OR, 1.33; 95% CI, 1.03–1.71), and cerebral atrophy (pooled OR, 2.83; 95% CI, 1.54–5.23) were significant risk factors for incident depression. Presence of deep WMHs (pooled OR, 1.47; 95% CI, 1.05–2.06) was a stronger predictor of depression than were periventricular WMHs (pooled OR, 1.31; 95% CI, 0.93–1.86). What's more, the pooled OR increased from 1.20 for the second quartile to 1.96 for the fourth quartile, indicating that higher the WMH severity brings greater risk of incident depression (25th–50th: pooled OR, 1.20; 95% CI, 0.68–2.12; 50th–75th; pooled OR, 1.42; 95% CI, 0.81–2.46; 75th–100th: OR, 1.96; 95% CI, 1.06–3.64). These results were stable to subgroup analysis for age, source of participants, follow‐up time, and methods for assessing WMHs and depression. Conclusions Cerebral small‐vessel disease features such as WMHs, enlarged perivascular spaces, and cerebral atrophy, especially the severity of WMHs and deep WMHs, are risk factors for incident depression.

scholarly journals Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

Aging ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2039-2061 ◽  
Author(s):  
Thalia S. Field ◽  
Fergus N. Doubal ◽  
Wendy Johnson ◽  
Ellen Backhouse ◽  
Caroline McHutchison ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Early Life ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Lothian Birth Cohort

scholarly journals Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life

2021 ◽  
Author(s):  
Michelle G Jansen ◽  
Ludovica Griffanti ◽  
Clare E Mackay ◽  
Melis Anatürk ◽  
Luca Melazzini ◽  
...  
Keyword(s):  
Brain Structure ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vascular Risk ◽  
Linear Mixed Effects ◽  
Vessel Disease

We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories of vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from the Whitehall II Imaging Sub-study with multi-modal MRI (mean age 69.96 SD=5.18, 79% men). We used linear mixed-effects models to investigate associations of SVD burden with up to 25-year retrospective trajectories of vascular risk and cognitive performance. General linear modelling was used to investigate concurrent associations with grey matter (GM) density and white matter (WM) microstructure, and whether these associations were modified by cognitive status (Montreal Cognitive Assessment, MoCA). Severe SVD burden in older age was associated with higher mean arterial pressure throughout midlife (β=3.36, 95% CI [0.42—6.30]), and faster 25-year cognitive decline in letter fluency (β=-0.07, 95% CI [-0.13—-0.01]), and verbal reasoning (β=-0.05, 95% CI [-0.11—-0.001]). Moreover, SVD burden was related to lower GM volumes in 9.7% of total GM, and widespread WM microstructural decline (FWE-corrected p<0.05). The latter association was most pronounced in individuals with cognitive impairments on MoCA (F3,608=2.14, p=0.007). These findings highlight the importance of managing midlife vascular health to preserve brain structure and cognitive function in old age.

scholarly journals Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease

Stroke ◽  
2017 ◽  
Vol 48 (12) ◽  
pp. 3196-3202 ◽  
Author(s):  
Keenan A. Walker ◽  
Melinda C. Power ◽  
Ron C. Hoogeveen ◽  
Aaron R. Folsom ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
White Matter ◽  
Systemic Inflammation ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life

2021 ◽  
pp. 0271678X2110484
Author(s):  
Michelle G Jansen ◽  
Ludovica Griffanti ◽  
Clare E Mackay ◽  
Melis Anatürk ◽  
Luca Melazzini ◽  
...  
Keyword(s):  
Brain Structure ◽  
Small Vessel Disease ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vascular Risk ◽  
Linear Mixed Effects ◽  
Vessel Disease

We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories of vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from the Whitehall II Imaging Sub-study with multi-modal MRI (mean age 69.96, SD = 5.18, 79% men). We used linear mixed-effects models to investigate associations of SVD burden with up to 25-year retrospective trajectories of vascular risk and cognitive performance. General linear modelling was used to investigate concurrent associations with grey matter (GM) density and white matter (WM) microstructure, and whether these associations were modified by cognitive status (Montreal Cognitive Asessment [MoCA] scores of < 26 vs. ≥ 26). Severe SVD burden in older age was associated with higher mean arterial pressure throughout midlife (β = 3.36, 95% CI [0.42-6.30]), and faster cognitive decline in letter fluency (β = −0.07, 95% CI [−0.13–−0.01]), and verbal reasoning (β = −0.05, 95% CI [−0.11–−0.001]). Moreover, SVD burden was related to lower GM volumes in 9.7% of total GM, and widespread WM microstructural decline (FWE-corrected p < 0.05). The latter association was most pronounced in individuals who demonstrated cognitive impairments on MoCA (MoCA < 26; F3,608 = 2.14, p = 0.007). These findings highlight the importance of managing midlife vascular health to preserve brain structure and cognitive function in old age.

scholarly journals Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study

Hypertension ◽  
2020 ◽  
Vol 76 (3) ◽  
pp. 707-714
Author(s):  
Rodica Elena Petrea ◽  
Adrienne O’Donnell ◽  
Alexa S. Beiser ◽  
Mohammad Habes ◽  
Hugo Aparicio ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Small Vessel Disease ◽  
Late Life ◽  
Brain Regions ◽  
Cerebral Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease ◽  
Brain Infarcts ◽  
Heart Study

The duration and lifetime pattern of hypertension is related to risk of stroke and dementia. In turn, cerebral small vessel disease (CSVD) is the most frequent form of cerebrovascular disease underlying dementia and stroke. Thus, study of the relation of mid to late life hypertension trends with CSVD late in life will help understand hypertension’s role and inform preventive efforts of CSVD consequences. We studied 1686 Framingham Heart Study Offspring cohort participants free of stroke and dementia, who were examined in mid and late life, and had available brain magnetic resonance imaging during late life. We related hypertension trends between mid and late life (normotension–normotension N-N, normotension-hypertension N-H, hypertension-hypertension H-H) to cerebral microbleeds and covert brain infarcts (CBI), overall and stratified by brain topography. We used multivariable logistic regression analyses to calculate odds ratio and 95% CIs for CSVD measures. The prevalence of CSVD in late life was 8% for cerebral microbleeds and 13% for covert brain infarcts and increased with longer hypertension exposure across all brain regions. Compared with the trend pattern of N-N, both N-H and H-H trends had higher odds of mixed cerebral microbleeds (2.71 [1.08–6.80], and 3.44 [1.39–8.60], respectively); H-H also had higher odds of any cerebral microbleeds or covert brain infarcts (1.54 [1.12–2.20]), and any covert brain infarcts (1.55 [1.08–2.20]). The burden of CSVD also increased with longer hypertension exposure. Our results highlight hypertension having a major role in subclinical CSVD, across subtypes and brain regions, and call attention to improve recognition and treatment of hypertension early in life.

scholarly journals Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes

2020 ◽  
Vol 5 (2) ◽  
pp. 128-137
Author(s):  
Huimin Chen ◽  
Yuesong Pan ◽  
Lixia Zong ◽  
Jing Jing ◽  
Xia Meng ◽  
...  
Keyword(s):  
Regression Models ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Arterial Stenosis ◽  
Small Vessel ◽  
Minor Stroke ◽  
Bleeding Events ◽  
Stroke Outcomes ◽  
Vessel Disease ◽  
Increased Risk

BackgroundThe effect of cerebral small vessel disease (CSVD) and intracranial arterial stenosis (ICAS) on stroke outcomes remains unclear.MethodsData of 1045 patients with minor stroke or transient ischaemic attack (TIA) were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial. We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale (mRS) scores using ordinal logistic regression models.ResultsAmong the 1045 patients, CSVD was present in 830 cases (79.4%) and ICAS in 460 (44.0%). Patients with >1 ICAS segment showed the highest risk of new strokes (HR 2.03, 95% CI 1.15 to 3.56, p=0.01). No association between CSVD and the occurrence of new strokes was found. The presence of severe CSVD (common OR (cOR) 2.01, 95% CI 1.40 to 2.89, p<0.001) and >1 ICAS segment (cOR 2.15, 95% CI 1.57 to 2.93, p<0.001) was associated with higher mRS scores. Severe CSVD (HR 10.70, 95% CI 1.16 to 99.04, p=0.04), but not ICAS, was associated with a higher risk of bleeding events. Six-point modified CSVD score improved the predictive power for bleeding events and disability.InterpretationCSVD is associated with more disability and bleeding events, and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months. CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes.Trial registration numberNCT00979589

scholarly journals Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction

2021 ◽  
pp. 0271678X2199262
Author(s):  
Shuai Jiang ◽  
Tian Cao ◽  
Yuying Yan ◽  
Tang Yang ◽  
Ye Yuan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Branch Atheromatous Disease ◽  
Lenticulostriate Artery ◽  
Subcortical Infarction

Recent subcortical infarction (RSI) in the lenticulostriate artery (LSA) territory with a non-stenotic middle cerebral artery is a heterogeneous entity. We aimed to investigate the role of LSA combined with neuroimaging markers of cerebral small vessel disease (CSVD) in differentiating the pathogenic subtypes of RSI by whole-brain vessel-wall magnetic resonance imaging (WB-VWI). Fifty-two RSI patients without relevant middle cerebral artery (MCA) stenosis on magnetic resonance angiography were prospectively enrolled. RSI was dichotomized as branch atheromatous disease (BAD; a culprit plaque located adjacent to the LSA origin) (n = 34) and CSVD-related lacunar infarction (CSVD-related LI; without plaque or plaque located distal to the LSA origin) (n = 18). Logistic regression analysis showed lacunes (odds ratio [OR] 9.68, 95% confidence interval [CI] 1.71–54.72; P = 0.010) and smaller number of LSA branches (OR 0.59, 95% CI 0.36–0.96; P = 0.034) were associated with of BAD, whereas severe deep white matter hyperintensities (DWMH) (OR 0.11, 95% CI 0.02–0.71; P = 0.021) was associated with CSVD-related LI. In conclusion, the LSA branches combined with lacunes and severe DWMH may delineate subtypes of SSI. The WB-VWI technique could be a credible tool for delineating the heterogeneous entity of SSI in the LSA territory.

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