[O4-06-03]: A NOVEL THERAPEUTIC APPROACH TO TREAT ALZHEIMER's DISEASE DURING THE BRAIN's SELF REPAIR ATTEMPT PERIOD

2017 ◽  
Vol 13 (7S_Part_26) ◽  
pp. P1241-P1242
Author(s):  
Narjes Baazaoui ◽  
Khalid Iqbal
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Approach ◽  
Self Repair ◽  
Repair Attempt ◽  
Novel Therapeutic

Plasma Exosomes as a Therapeutic Approach Prevent the Cognitive Decline by Inhibiting Tau Protein Hyperphosphorylation in Alzheimer’s Disease Mice

2021 ◽  
Vol 11 (2) ◽  
pp. 221-228
Author(s):  
Lijuan Huang ◽  
Hao Wang ◽  
Haijuan Sui ◽  
Yijie Shi ◽  
Liang Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Therapeutic Approach ◽  
Bioinformatics Analysis ◽  
Cognitive Impairments ◽  
Cognitive Disorder ◽  
Pathological Process ◽  
Exosomal Mirnas ◽  
Novel Therapeutic

It was well known that circulating plasma exosomes (Pla-Exo) were enriched with multiple microRNAs (miRNAs) and participated in the regulation of biological and pathological process via exchanging information and transferring substance into targeted cells and organs. Therefore, clinical significance of Pla-Exo had been recognized and they functioned as biomarkers for the clinical diagnosis or therapeutic applications to treat diseases. We explored the possibility of using Pla-Exo as a novel therapeutic approach for ameliorating cognitive dysfunction in Alzheimer’s disease (AD) mice. Here we found that Pla-Exo freely crossed the blood-brain barrier (BBB) and was transferred into the hippocampus of mice. After following peritoneal injection (I.P.) of Pla-Exo, survival of neuron cells was enhanced and cognitive disorder was attenuated in okadaic acid (OA) treated mice via deactivating GSK-3β and down-regulating GSK-3β mediated hyperphosphorylation of Tau protein. Finally, some potential exosomal miRNAs were screened by bioinformatics analysis and confirmed their target of GSK-3β. Taken together, all data proved that Pla-Exo contributed to the amelioration of cognitive impairments.

P2-368: Innate immunity stimulation as a novel therapeutic approach in Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_11) ◽  
pp. P392-P392 ◽  
Author(s):  
Henrieta Scholtzova ◽  
Fernando Goni ◽  
Jason Pan ◽  
Yanjie Sun ◽  
Jialin Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Innate Immunity ◽  
Therapeutic Approach ◽  
Novel Therapeutic

P4-018: Innate Immunity Stimulation Via Toll-Like Receptor 9 as a Novel Therapeutic Approach in Alzheimer’s Disease

2016 ◽  
Vol 12 ◽  
pp. P1021-P1022 ◽  
Author(s):  
Henrieta Scholtzova ◽  
Pramod N. Nehete ◽  
Bharti P. Nehete ◽  
Elizabeth Cho ◽  
Melanie M. Mallory ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Innate Immunity ◽  
Therapeutic Approach ◽  
Toll Like Receptor ◽  
Novel Therapeutic

P3-050: An Affibody to Monomeric Aβ as a Novel Therapeutic Approach for Alzheimer's Disease Pathology

2016 ◽  
Vol 12 ◽  
pp. P835-P836 ◽  
Author(s):  
Allal Boutajangout ◽  
Hanna Lindberg ◽  
Abdulaziz Awwad ◽  
Arun Paul ◽  
Rabaa Baitalmal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Approach ◽  
Novel Therapeutic
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