Risk Factors for Developing Post-Transplant Malignancy in Children Who Receive a Kidney Transplant: Analysis of 1,055 Kidney Transplants between 1963 and 2015 at a Single Institution

2016 ◽  
Vol 223 (4) ◽  
pp. S149
Author(s):  
Oscar K. Serrano ◽  
Ananta Bangdiwala ◽  
David Vock ◽  
Ty B. Dunn ◽  
Srinath Chinnakotla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Kidney Transplants ◽  
Single Institution ◽  
Post Transplant

scholarly journals Cardiovascular risk assessment by Framingham score pre and post kidney transplant

2016 ◽  
Vol 19 (2) ◽  
pp. 13-17
Author(s):  
Marcos Vinicius de Sousa ◽  
Nayara Tenório ◽  
Carla Feitosa do Valle ◽  
Marilda Mazzali
Keyword(s):  
Risk Factors ◽  
Total Cholesterol ◽  
Kidney Transplant ◽  
Risk Score ◽  
Graft Loss ◽  
Left Ventricular ◽  
Inclusion Criteria ◽  
Kidney Transplants ◽  
Post Transplant ◽  
Significant Difference

Cardiovascular mortality is the main cause for graft loss after a successful kidney transplant. Purpose: To analyze the risk for cardiovascular events by the Framinghan risk score, pre and 1-year after kidney transplant. Methods: Retrospective study analyzing the transplant Unit database of kidney transplants performed from January 2010 to January 2012. Inclusion criteria: age >18 years old, functioning graft 12 months post-transplant. Exclusion criteria: patient death or graft loss within the first year after transplant. Demographic and laboratory data were collected pre and 12 months post-transplant; the Framinghan risk score was calculated at those points. Pre-transplant echocardiogram was also analyzed. Results: From 230 kidney transplants performed during the studied period, 167 fulfilled the inclusion criteria. Sixty-three were excluded due to death or graft loss (n=29) or insufficient data for analysis. In the majority, the studied group was male (64.6%), mean age of 47.9+11.1 years old and recipients from deceased donor (97%). Echocardiogram showed a 67.5 +6.6% ejection fraction, left ventricular hypertrophy in 98%, with a low incidence of valvar calcification (2.5%). Framinghan score was similar pre and after transplant (16.4+14.9 vs. 18.3 +17.2, p=ns). However, analysis of isolated parameters showed a significant difference pre and after transplant. While pre-transplant risk factors were high blood pressure, lower HDL cholesterol, and active smoking, post-transplant risk factors were the occurrence of diabetes, higher total cholesterol that required anti-hypertensive therapy. Conclusion: the early after transplant results, recovery of renal function, hematocrit and nutritional levels in the body weight gain usually along with impaired metabolic parameters, mainly total cholesterol, triglyceryde and uric acid maintained a similar Framinghan risk score as pre-transplant levels.

scholarly journals COVID-19 Infection in Kidney Transplant Recipients: Disease Incidence and Clinical Outcomes

2020 ◽  
Vol 31 (10) ◽  
pp. 2413-2423 ◽  
Author(s):  
Michelle Elias ◽  
Daniele Pievani ◽  
Christine Randoux ◽  
Kevin Louis ◽  
Blandine Denis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Disease ◽  
Kidney Transplant ◽  
Disease Incidence ◽  
High Morbidity ◽  
Chronic Pulmonary Disease ◽  
Transplant Recipients ◽  
Kidney Transplants ◽  
Kidney Transplant Recipients ◽  
White Ethnicity

BackgroundCOVID-19 has been associated with high morbidity and mortality in kidney transplant recipients. However, risk factors for COVID-19 disease in patients with kidney transplants remain poorly defined.MethodsWe enrolled patients who underwent kidney transplantation and were actively followed up in two hospitals in Paris on March 1st, 2020. Patients were screened for baseline and transplant characteristics, functional parameters, comorbidities, and immunosuppressive therapies. COVID-19 disease was assessed. Patients were followed up during the pandemic until April 30th, 2020 by the COVID-19 SLS KT survey program, including teleconsulting, at-home monitoring for patients with COVID-19, and a dedicated phone hotline platform.ResultsAmong 1216 patients with kidney transplants enrolled, 66 (5%) patients were identified with COVID-19 disease, which is higher than the incidence observed in the general population in France (0.3%). Their mean age was 56.4±12.5 years, and 37 (56%) patients were men. The following factors were independently associated with COVID-19 disease: non-White ethnicity (adjusted odds ratio [OR], 2.17; 95% confidence interval [95% CI], 1.23 to 3.78; P=0.007), obesity (OR, 2.19; 95% CI, 1.19 to 4.05; P=0.01), asthma and chronic pulmonary disease (OR, 3.09; 95% CI, 1.49 to 6.41; P=0.002), and diabetes (OR, 3.33; 95% CI, 1.92 to 5.77; P<0.001). The mortality rate related to COVID-19 disease was 1% in the overall study population and 24% in COVID-19–positive patients.ConclusionsPatients with kidney transplants display a high risk of mortality. Non-White ethnicity and comorbidities such as obesity, diabetes, asthma, and chronic pulmonary disease were associated with higher risk of developing COVID-19 disease. It is imperative that policy makers urgently ensure the integration of such risk factors on response operations against COVID-19.

scholarly journals Associations between pre-kidney-transplant risk factors and post-transplant cardiovascular events and death

2008 ◽  
Vol 21 (10) ◽  
pp. 985-991 ◽  
Author(s):  
Jeroen Aalten ◽  
Ellen K. Hoogeveen ◽  
Joke I. Roodnat ◽  
Willem Weimar ◽  
George F. Borm ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Cardiovascular Events ◽  
Post Transplant

scholarly journals PRE-KIDNEY TRANSPLANT RISK FACTORS AND POST-TRANSPLANT CARDIOVASCULAR AND ALL-CAUSE MORTALITY

2010 ◽  
Vol 90 ◽  
pp. 722
Author(s):  
G. Wong ◽  
K. Howard ◽  
J. R. Chapman ◽  
S. Chadban ◽  
N. B. Cross ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Post Transplant ◽  
All Cause Mortality

scholarly journals Post-Transplant Cardiovascular Disease

2021 ◽  
pp. CJN.00520121
Author(s):  
Kelly A. Birdwell ◽  
Meyeon Park
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Kidney Transplant ◽  
Optimal Strategies ◽  
Future Research ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Treatment And Prevention ◽  
Artery Disease

Cardiovascular disease remains a leading cause of death and morbidity in kidney transplant recipients and a common reason for post-transplant hospitalization. Several traditional and nontraditional cardiovascular risk factors exist, and many of them present pretransplant and worsened, in part, due to the addition of immunosuppression post-transplant. We discuss optimal strategies for identification and treatment of these risk factors, including the emerging role of sodium-glucose cotransporter 2 inhibitors in post-transplant diabetes and cardiovascular disease. We present common types of cardiovascular disease observed after kidney transplant, including coronary artery disease, heart failure, pulmonary hypertension, arrhythmia, and valvular disease. We also discuss screening, treatment, and prevention of post-transplant cardiac disease. We highlight areas of future research, including the need for goals and best medications for risk factors, the role of biomarkers, and the role of screening and intervention.

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