scholarly journals Multi-Center Analysis of Liver Transplantation for Combined Hepatocellular Carcinoma-Cholangiocarcinoma Liver Tumors

2020 ◽  
Author(s):  
Leigh Anne Dageforde ◽  
Neeta Vachharajani ◽  
Parissa Tabrizian ◽  
Vatche Agopian ◽  
Karim Halazun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Tumors

scholarly journals HEPATOCELLULAR CARCINOMA: DIAGNOSIS AND OPERATIVE MANAGEMENT

2017 ◽  
Vol 30 (4) ◽  
pp. 272-278 ◽  
Author(s):  
Marcio F. CHEDID ◽  
Cleber R. P. KRUEL ◽  
Marcelo A. PINTO ◽  
Tomaz J. M. GREZZANA-FILHO ◽  
Ian LEIPNITZ ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Tumors ◽  
Tumor Resection ◽  
Malignant Neoplasm ◽  
Operative Management ◽  
Chronic Viral Hepatitis ◽  
Curative Treatment ◽  
Intravenous Contrast ◽  
Hepatocellular Carcinomas

ABSTRACT Introduction: Hepatocellular carcinoma is an aggressive malignant tumor with high lethality. Aim: To review diagnosis and management of hepatocellular carcinoma. Methods: Literature review using web databases Medline/PubMed. Results: Hepatocellular carcinoma is a common complication of hepatic cirrhosis. Chronic viral hepatitis B and C also constitute as risk factors for its development. In patients with cirrhosis, hepatocelular carcinoma usually rises upon malignant transformation of a dysplastic regenerative nodule. Differential diagnosis with other liver tumors is obtained through computed tomography scan with intravenous contrast. Magnetic resonance may be helpful in some instances. The only potentially curative treatment for hepatocellular carcinoma is tumor resection, which may be performed through partial liver resection or liver transplantation. Only 15% of all hepatocellular carcinomas are amenable to operative treatment. Patients with Child C liver cirrhosis are not amenable to partial liver resections. The only curative treatment for hepatocellular carcinomas in patients with Child C cirrhosis is liver transplantation. In most countries, only patients with hepatocellular carcinoma under Milan Criteria are considered candidates to a liver transplant. Conclusion: Hepatocellular carcinoma is potentially curable if discovered in its initial stages. Medical staff should be familiar with strategies for early diagnosis and treatment of hepatocellular carcinoma as a way to decrease mortality associated with this malignant neoplasm.

scholarly journals Histological Correlation for Radiofrequency and Microwave Ablation in the Local Control of Hepatocellular Carcinoma (HCC) before Liver Transplantation: A Comprehensive Review

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 104
Author(s):  
Peiman Habibollahi ◽  
Rahul A. Sheth ◽  
Erik N. K. Cressman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Microwave Ablation ◽  
Liver Tumors ◽  
High Specificity ◽  
Lesion Size ◽  
Ablation Techniques ◽  
High Rate ◽  
Pathological Findings ◽  
Comprehensive Review

Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most widely studied and applied ablation techniques for treating primary and secondary liver tumors. These techniques are considered curative for small hepatic tumors, with post-ablation outcomes most commonly assessed by an imaging follow up. However, there is increasing evidence of a discrepancy between radiological and pathological findings when ablated lesions are evaluated following liver resection or liver transplantation. A comprehensive review of the available literature reporting the complete pathological response (cPR) following RFA and MWA was performed to estimate the success rate and identify the factors associated with treatment failure. Following RFA, cPR is reported in 26–96% of tumors compared to 57–95% with MWA. Larger tumor size and vessels larger than 3 mm adjacent to the treated tumor are the most important factors identified by previous studies associated with viable residual tumors after RFA. Correlating post-ablation radiological studies with pathological findings shows that computed tomography (CT) and magnetic resonance imaging (MRI) have low sensitivity but high specificity for detecting residual viable or recurrent hepatocellular carcinoma (HCC) tumors. There are promising recent reports combining multiprobe ablation techniques with three-dimensional treatment planning software and stereotactic-aiming instrumentation to achieve more than 90% cPR in both small and large HCC tumors. In conclusion, the reported success for achieving cPR in HCC following RFA and MWA is highly variable in different studies and decreases with increasing lesion size and unfavorable tumor characteristics. Very few studies have reported a high rate of cPR. As these studies are single-center and retrospective, they need to be further validated and reproduced in other clinical settings.

Outcome of patients with recurrent hepatocellular carcinoma after liver transplantation

2010 ◽  
Vol 48 (05) ◽  
Author(s):  
A Finkenstedt ◽  
I Graziadei ◽  
H Zoller ◽  
K Nachbaur ◽  
W Mark ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Recurrent Hepatocellular Carcinoma

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Wiltberger ◽  
U Lange ◽  
H Hau ◽  
D Seehofer ◽  
F Krenzien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Coffee Consumption ◽  
Protective Effects

Liver transplantation for hepatocellular carcinoma: A single center experience

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
V Stadlbauer ◽  
S Schaffellner ◽  
D Kniepeiss ◽  
E Jakoby ◽  
F Iberer ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Single Center ◽  
Single Center Experience

Mechanisms of liver damage in COVID-19

2020 ◽  
Vol 1 (19) ◽  
pp. 39-46
Author(s):  
T. V. Pinchuk ◽  
N. V. Orlova ◽  
T. G. Suranova ◽  
T. I. Bonkalo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Risk Factor ◽  
Liver Disease ◽  
Liver Function ◽  
Liver Damage ◽  
The World ◽  
Coronavirus Infection ◽  
The Impact ◽  
Analyze Data

At the end of 2019, a new coronavirus (SARS-CoV-2) was discovered in China, causing the coronavirus infection COVID-19. The ongoing COVID-19 pandemic poses a major challenge to health systems around the world. There is still little information on how infection affects liver function and the significance of pre-existing liver disease as a risk factor for infection and severe COVID-19. In addition, some drugs used to treat the new coronavirus infection are hepatotoxic. In this article, we analyze data on the impact of COVID-19 on liver function, as well as on the course and outcome of COVID-19 in patients with liver disease, including hepatocellular carcinoma, or those on immunosuppressive therapy after liver transplantation.

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