Are there Differences in Effectiveness of Ferrous Sulfate Compared to Ferrous Fumarate to Raise Serum Ferritin Levels among Collegiate Athletes with Compromised Levels?

2015 ◽  
Vol 115 (9) ◽  
pp. A72
Author(s):  
A. Brunt ◽  
S. Stastny ◽  
H. Grinaker
Keyword(s):  
Serum Ferritin ◽  
Ferrous Sulfate ◽  
Collegiate Athletes ◽  
Ferrous Fumarate

scholarly journals Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2160
Author(s):  
Malaine Morais Alves Machado ◽  
Mirella de Paiva Lopes ◽  
Raquel Machado Schincaglia ◽  
Paulo Sérgio Sucasas da Costa ◽  
Alexandre Siqueira Guedes Coelho ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Transferrin Receptor ◽  
Ferrous Sulfate ◽  
Soluble Transferrin Receptor ◽  
Standard Drug ◽  
Micronutrient Powder ◽  
Prevention And Treatment ◽  
Multiple Micronutrient ◽  
Multiple Micronutrient Powder

Fortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and treatment of iron deficiency and anaemia. This was a cluster trial with anemic and non-anaemic children between six and 42 months old, in randomization data. Non anaemic children received fortification with multiple micronutrient powder or standard drug supplementation of ferrous sulfate associated with folic acid in a prevention dose. Anaemic children who were randomized to receive multiple micronutrient powder also received the recommended iron complementation for anaemia treatment. A total of 162 children were evaluated. The prevalence of anaemia decreased from 13.58 to 1.85%. Iron deficiency decreased from 21.74% to 7.89% (by serum ferritin) and iron deficiency decreased from 66.81 to 38.27% (by soluble transferrin receptor). No difference was identified between interventions for hemoglobin (p = 0.142), serum ferritin (p = 0.288), and soluble transferrin receptor (p = 0.156). Fortification with multiple micronutrient powder was effective in preventing iron deficiency and anaemia in children aged six to 48 months. In anaemic children; it was necessary to supplement the dose of multiple micronutrient powder with ferrous sulfate.

scholarly journals Acute Consumption of Prebiotic Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate, but not from Ferrous Sulfate and Ferric Pyrophosphate: Stable Iron Isotope Studies in Iron-Depleted Young Women

2020 ◽  
Vol 150 (9) ◽  
pp. 2391-2397
Author(s):  
Frederike M D Jeroense ◽  
Christophe Zeder ◽  
Michael B Zimmermann ◽  
Isabelle Herter-Aeberli
Keyword(s):  
Stable Isotopes ◽  
Ferrous Sulfate ◽  
Iron Absorption ◽  
Ferric Pyrophosphate ◽  
Ferrous Fumarate ◽  
Paired Samples ◽  
Wilcoxon Rank Sum Test ◽  
Isotope Studies ◽  
High Doses ◽  
Dose Dependent

ABSTRACT Background Although acute consumption of high doses of prebiotic galacto-oligosaccharides (GOS) increases fractional iron absorption (FIA) from ferrous fumarate (FeFum), it is uncertain if low doses of GOS have this effect. Furthermore, whether GOS improve iron absorption from other commonly used iron compounds and whether ascorbic acid (AA) enhances the effect of GOS on iron absorption from FeFum is unclear. Objectives In iron-depleted women [serum ferritin (SF) <30 μg/L], we assessed: 1) whether the acute enhancing effect of GOS on FeFum is dose dependent; 2) if GOS would affect FIA from ferrous sulfate (FeSO4) or ferric pyrophosphate (FePP); and 3) if AA and GOS given together enhance FIA from FeFum to a greater extent compared with GOS alone. Methods We recruited 46 women (mean age 22.0 y, mean BMI 21.3 kg/m2, median SF 17.1 μg/L), and measured FIA from 14 mg iron labeled with stable isotopes in the following conditions: 1) FIA from FeFum given with 3.5 g, 7 g GOS, and without GOS; 2) FIA from FeSO4 and FePP given with and without 15 g GOS; and 3) FIA from FeFum given with 7 g GOS with and without 93 mg AA. FIA was measured as erythrocyte incorporation of stable isotopes after 14 d. Comparisons were made using paired samples t-test or Wilcoxon rank sum test where appropriate. Results Giving 7 g of GOS significantly increased FIA from FeFum (+26%; P = 0.039), whereas 3.5 g GOS did not (P = 0.130). GOS did not significantly increase FIA from FeSO4 (P = 0.998) or FePP (P = 0.059). FIA from FeFum given with GOS and AA was significantly higher compared with FeFum given with GOS alone (+30%; P <0.001). Conclusions In iron-depleted women, GOS does not increase FIA from FeSO4 or FePP, but it increases FIA from FeFum. Thus, a combination of FeFum and GOS may be a well-absorbed formula for iron supplements. The study was registered at clinicaltrials.gov as NCT03762148.

scholarly journals Paradoxical Relationships between Serum 25(OH)D and Ferritin with Body Composition and Burnout: Variation by Sex and Sports Team

Endocrines ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 320-333
Author(s):  
Tamara Hew-Butler ◽  
Carrie Aprik ◽  
Brigid Byrd ◽  
Kristin Landis-Piwowar ◽  
Valerie Smith-Hale ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Body Fat ◽  
Serum Ferritin ◽  
Lean Mass ◽  
Serum Vitamin ◽  
Collegiate Athletes ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Athlete Burnout

Adequate serum vitamin D and iron levels are thought to influence physical training adaptations and mood positively. The primary purpose of this prospective, observational study was to investigate relationships between serum 25-OH vitamin D/25(OH)D and serum ferritin levels with body composition and athlete burnout symptoms. Seventy-three collegiate athletes (female: n = 49; male: n = 24) from indoor (swimming, basketball) and outdoor (soccer, cross-country) sports were tested pre-season and post-season for serum 25(OH)D and serum ferritin (nutrient biomarkers) via venipuncture; body composition (total lean mass, bone mineral density/BMD, and % body fat) via dual energy X-ray absorptiometry (DXA) scans; and athlete burnout symptoms (post-season) via the athlete burnout questionnaire (ABQ). When male and female cohorts were combined, significant correlations (Pearson’s r) were noted between pre-season serum 25(OH)D versus the change (∆: post-season minus pre-season) in both BMD (r = −0.34; p = 0.0003) and % body fat (r = −0.28; p = 0.015). Serum ferritin ∆ was significantly associated with lean mass ∆ (r = −0.34; p = 0.003). For burnout symptoms, serum 25(OH)D ∆ significantly explained 20.6% of the variance for devaluation of the sport in the male cohort only. Across time, serum 25(OH)D levels decreased while serum ferritin levels increased, non-significantly, in both males and females. Relationships between nutrient biomarkers and body composition were opposite of physiological expectations.

scholarly journals Preoperative Epoetin-α with Intravenous or Oral Iron for Major Orthopedic Surgery

2018 ◽  
Vol 129 (4) ◽  
pp. 710-720 ◽  
Author(s):  
Philippe Biboulet ◽  
Sophie Bringuier ◽  
Pierre Smilevitch ◽  
Thibault Loupec ◽  
Caroline Thuile ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Orthopedic Surgery ◽  
Ferrous Sulfate ◽  
Ferritin Level ◽  
Intravenous Iron ◽  
Interquartile Range ◽  
Ferric Carboxymaltose ◽  
Clinical Effects ◽  
Preoperative Administration ◽  
Major Orthopedic Surgery

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Preoperative administration of epoetin-α with iron is commonly used in anemic patients undergoing major orthopedic surgery, but the optimal route of iron intake is controversial. The aim of this study was to compare the clinical effects of erythropoietin in combination with oral or intravenous iron supplementation. Methods This study was a prospective, randomized, single-blinded, parallel arm trial. Patients scheduled for elective hip or knee arthroplasty with hemoglobin 10 to 13 g/dl received preoperative injections of erythropoietin with oral ferrous sulfate or intravenous ferric carboxymaltose. The primary endpoint was the hemoglobin value the day before surgery. Results One hundred patients were included in the analysis. The day before surgery, hemoglobin, increase in hemoglobin, and serum ferritin level were higher in the intravenous group. For the intravenous and oral groups, respectively, hemoglobin was as follows: median, 14.9 g/dl (interquartile range, 14.1 to 15.6) versus 13.9 g/dl (interquartile range, 13.2 to 15.1), group difference, 0.65 g/dl (95% CI, 0.1 to 1.2; P = 0.017); increase in hemoglobin: 2.6 g/dl (interquartile range, 2.1 to 3.2) versus 1.9 g/dl (interquartile range, 1.4 to 2.5), group difference, 0.7 g/dl (95% CI, 0.3 to 1.1; P < 0.001); serum ferritin: 325 µg/l (interquartile range, 217 to 476) versus 64.5 µg/l (interquartile range, 44 to 107), group difference, 257 µg/l (95% CI, 199 to 315; P < 0.001). The percentage of patients with nausea, diarrhea, or constipation was higher in the oral group, 52% versus 2%; group difference, 50% (95% CI, 35 to 64%; P < 0.0001). Conclusions After preoperative administration of erythropoietin, body iron stores and stimulation of the erythropoiesis were greater with intravenous ferric carboxymaltose than with oral ferrous sulfate supplementation.

The Potential of Encapsulated Iron Compounds in Food Fortification: A Review

2004 ◽  
Vol 74 (6) ◽  
pp. 453-461 ◽  
Author(s):  
Zimmermann
Keyword(s):  
Ferrous Sulfate ◽  
Relative Bioavailability ◽  
Food Supplement ◽  
Iron Bioavailability ◽  
Ammonium Citrate ◽  
Ferric Ammonium Citrate ◽  
Food Fortification ◽  
Ferrous Fumarate ◽  
Ferric Ammonium ◽  
Sensory Changes

Iron (Fe) encapsulation has the potential to help overcome several major challenges in Fe fortification of foods. It may decrease unwanted sensory changes in fortified products and reduce interactions of Fe with food components that lower Fe bioavailability. However, the effect of encapsulation per se on Fe bioavailability is a concern. Rat studies comparing encapsulated ferrous sulfate, ferric ammonium citrate, and ferrous fumarate to non-encapsulated compounds indicate that a ratio of capsule:substrate of _ 60:40 may decrease the relative bioavailability (RBV) of the Fe by approximately 20%. At a ratio of capsule:substrate of _ 50: 50, the RBV of encapsulated ferrous sulfate appears to be similar to ferrous sulfate. Even minor changes in capsule composition may influence Fe bioavailability. Encapsulated ferrous fumarate given with ascorbic acid as a complementary food supplement and encapsulated ferrous sulfate fortified into salt have been shown to be efficacious in anemic children. For salt fortification, further refinements in Fe capsule design are needed to increase resistance to moisture and abrasion, while maintaining bioavailability. Studies evaluating the potential efficacy of encapsulated Fe in staple cereals (wheat and maize flours) are needed. A potential barrier to use of encapsulated forms of Fe in staple food fortification is the relatively low melting point of the capsules, which may cause unwanted sensory changes during food preparation. Research and development efforts to improve the quality of coatings and their resistance to high temperatures are ongoing. Process costs for encapsulation can be high, and unless they can be reduced, may limit applications. Further research is needed to determine which encapsulation technologies are most effective in ensuring iron bioavailability from encapsulated compounds.

Variations of 57Fe hyperfine parameters in medicaments containing ferrous fumarate and ferrous sulfate

2010 ◽  
pp. 287-294
Author(s):  
M. I. Oshtrakh ◽  
E. G. Novikov ◽  
S. M. Dubiel ◽  
V. A. Semionkin
Keyword(s):  
Ferrous Sulfate ◽  
Hyperfine Parameters ◽  
Ferrous Fumarate

scholarly journals Investigation on Haematinic accessible Assortments and Measurable Structures available in Indian Markets

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 704-708
Author(s):  
Rekha Kumari ◽  
Hariprasad Rao L ◽  
Gopinath T T ◽  
Pandiyan K R
Keyword(s):  
Carbonyl Iron ◽  
Ferrous Sulfate ◽  
Ferric Hydroxide ◽  
Ammonium Citrate ◽  
Ferrous Fumarate ◽  
Oral Fluids ◽  
Iron Salts ◽  
Sodium Hydrate ◽  
Iron Iron ◽  
Parenteral Iron

To investigate Haematinic definitions accessible in India arcade for their assortments of measurements structures, hard salts utilized, the substance of essential iron, recurrence of organization compulsory, the occurrence of extra supplements, levelheadedness and price. Haematinic details recorded in IDR 2018, were investigated for salts of Iron present. Arrangements of ferrous fumarate were additionally investigated for Iron substance, presence of folic corrosive and other included extra parts. A sum of 522 plans, 291 (55.74%) was oral strong measurement structure, 206 (39.46%) were oral fluids and 25 (4.7%) were parenteral. Iron salts in these details were in a type of ferrous fumarate, carbonyl iron, iron ascorbate, iron ammonium citrate, ferric hydroxide polymaltose perplexing, ferrous sulfate, sodium hydrate. Carbonyl iron was available in 92 arrangements and was most ordinarily utilized readiness in oral strong plans. A few details moreover contained Vitamin B12, zinc sulfate, histidine, lysine different multivitamins and calcium arrangements in factor extent. Out of 291 oral strong, 45 (15.46 %) arrangements required organization > three times each day to accomplish the remedial fixation. The normal expense of the sound planning was more than the normal expense of silly arrangement. Investigation of different haematinics shows there is no consistency in details. Iron and folic corrosive are included wide factor range in addition, different substances were additionally included with no very much demonstrated proof. Steps ought to be taken to normalize these details.

scholarly journals Changes in Nutrient Biomarkers, Body Composition, and Burnout Symptoms in Collegiate Athletes across a Season

2021 ◽  
Author(s):  
Tamara Hew-Butler ◽  
Carrie Aprik ◽  
Brigid Byrd ◽  
Kristin Landis-Piwowar ◽  
Valerie Smith-Hale ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Body Fat ◽  
Serum Ferritin ◽  
Lean Mass ◽  
Serum Vitamin ◽  
Collegiate Athletes ◽  
Vitamin D Levels ◽  
Athlete Burnout ◽  
25 Oh Vitamin D

Adequate serum vitamin D and iron levels are thought to positively influence physical training adaptations and mood. The purpose of this prospective, observational, study was to investigate relationships between serum 25-OH vitamin D and serum ferritin levels with body composition and athlete burnout symptoms. Seventy-three collegiate athletes (49 female) from 7 indoor and outdoor sports were tested pre-season and post-season for: nutrient biomarkers (serum 25-OH vitamin D and serum ferritin) via venipuncture; body composition (total lean mass, bone mineral densi-ty/BMD, and % body fat) via dual energy x-ray absorptiometry (DXA) scans; and athlete burnout symptoms (post-season) via the athlete burnout questionnaire (ABQ). When male and female co-horts were combined, significant relationships were noted between pre-season serum 25-OH vit-amin D versus the change (∆: post-season minus pre-season) in both BMD (r=-0.34;p=0.0003) and % body fat (r=-0.28;p=0.015). Serum ferritin ∆ was significantly associated with lean mass ∆ (r=-0.34;p=0.003). For burnout symptoms, serum 25-OH vitamin D ∆ significantly explained 20.6% of the variance for devaluation of sport in the male cohort only. Across time, serum 25-OH vitamin D levels increased while serum ferritin levels decreased, non-significantly, in both males and fe-males. Relationships between nutrient biomarkers and body composition were opposite of physio-logical expectations.

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