scholarly journals Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet

2018 ◽  
Vol 118 (4) ◽  
pp. 589-605 ◽  
Author(s):  
Dolores Corella ◽  
Judith B. Ramírez-Sabio ◽  
Oscar Coltell ◽  
Carolina Ortega-Azorín ◽  
Ramón Estruch ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ogg1 Gene ◽  
All Cause Mortality ◽  
Ser326cys Polymorphism ◽  
Predimed Study

scholarly journals Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study

2014 ◽  
Vol 100 (6) ◽  
pp. 1498-1507 ◽  
Author(s):  
Pilar Buil-Cosiales ◽  
Itziar Zazpe ◽  
Estefanía Toledo ◽  
Dolores Corella ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Fiber Intake ◽  
All Cause Mortality ◽  
Predimed Study ◽  
Dieta Mediterranea ◽  
Dieta Mediterránea

Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer

2018 ◽  
Vol 90 (2) ◽  
pp. 13-15 ◽  
Author(s):  
Jacek Kabzinski ◽  
Anna Walczak ◽  
Adam Dziki ◽  
Michał Mik ◽  
Ireneusz Majsterek
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Oxidative Damage ◽  
Oxidative Dna Damage ◽  
Excision Repair ◽  
Genetic Material ◽  
Control Group ◽  
Ogg1 Gene ◽  
Increased Risk ◽  
Ser326cys Polymorphism

As a result of reactive oxygen species operation, cell damage occurs in both cellular organelles and molecules, including DNA. Oxidative damage within the genetic material can lead to accumulation of mutations and consequently to cancer transformation. OGG1 glycosylase, a component of the Base Excision Repair (BER) system, is one of the enzymes that prevents excessive accumulation of 8-oxoguanine (8-oxG), the most common compound formed by oxidative DNA damage. In case of structural changes of OGG1 resulting from polymorphic variants, we can observe a significant increase in the concentration of 8-oxG. Linking individual polymorphisms to DNA repair systems with increased risk of colorectal cancer will allow patients to be classified as high risk and included in a prophylactic program. The aim of the study was to determine the level of oxidative DNA damage and to analyze the distribution of Ser326Cys polymorphism of the OGG1 gene in a group of patients with colorectal cancer and in a control group in the Polish population. Material and methodology. DNA was isolated from the blood of 174 patients with colorectal cancer. The control group consisted of 176 healthy individuals. The level of oxidative damage was determined by analyzing the amount of 8-oxguanine using the HT 8-oxo-dG ELISA II Kit. Genotyping was performed via the TaqMan method. Results. The obtained results indicate that Ser326Cys polymorphism of the OGG1 gene increases the risk of RJG and is associated with significantly increased levels of 8-oxoguanine. Conclusions. Based on the results obtained, we conclude that Ser326Cys polymorphism of the OGG1 gene may modulate the risk of colorectal cancer by increasing the level of oxidative DNA damage.

DNA Repair Gene 8-Oxoguanine DNA Glycosylase Ser326Cys Polymorphism and Colorectal Cancer Risk in a Kashmiri Population

2012 ◽  
Vol 31 (4) ◽  
pp. 541-546 ◽  
Author(s):  
A. Syed Sameer ◽  
Saniya Nissar ◽  
Safiya Abdullah ◽  
Nissar A. Chowdri ◽  
Mushtaq A. Siddiqi
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Dna Glycosylase ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Ser326cys Polymorphism ◽  
Kashmiri Population

Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM

2009 ◽  
Vol 386 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Makoto Daimon ◽  
Toshihide Oizumi ◽  
Sayumi Toriyama ◽  
Shigeru Karasawa ◽  
Yumi Jimbu ◽  
...  
Keyword(s):  
Ogg1 Gene ◽  
Type 2 Dm ◽  
Ser326cys Polymorphism

scholarly journals Association study between polymorphisms of XRCC1, hOGG1 in DNA repair gene and the risk of endometrial carcinoma: a meta-analysis

2019 ◽  
Author(s):  
huang wen ◽  
Zhou xiaosi ◽  
yi li ◽  
zhihao wang
Keyword(s):  
Dna Repair ◽  
Endometrial Carcinoma ◽  
Meta Analysis ◽  
Xrcc1 Gene ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Hogg1 Gene ◽  
Increase Risk ◽  
Arg399gln Polymorphism ◽  
Ser326cys Polymorphism

Abstract Objective The association of DNA repair gene XRCC1, hOGG1 polymorphisms with susceptibility to endometrial carcinoma (EC) have been extensively studied with inconsistent results. The objective of this study was to clarify this issue by a comprehensive review and meta-analysis. Methods English (PubMed, Medline, Embase) and Chinese (CNKI, wanfang) electric databases were searched to collect a case-control study on the association between XRCC1 or hOGG1 gene polymorphisms and endometrial carcinoma. The retrieval time was from the database until may 1th, 2019. According to inclusion and exclusion criteria, relevant data of the final included literature were extracted and STATA 11.0 software was used for meta analysis. Results A total of 8 references meeting the inclusion criteria were included for analysis from the 243 retrieved literatures. The Arg399Gln polymorphism at the XRCC1 gene was associated with increased susceptibility to endometrial carcinoma (OR=1.36, 95%CI=1.23~1.51, P<0.001) in the overall population, the same results were shown in the subgroup analysis of Caucasians (OR=1.44, 95%CI=1.29~1.61, P<0.001). Ser326Cys polymorphism of the hOGG1 gene also increases the risk of endometrial carcinoma in Caucasians (OR=1.54, 95%CI=1.34~1.76, P=0.001). No publication bias was detected in this meta-analysis. Conclusions This meta-analysis provided evidence that the Arg399Gln polymorphism of DNA repair gene XRCC1 may increase risk of endometrial carcinoma, especially in the Caucasian. Moreover, Ser326Cys polymorphism of hOGG1 increase endometrial carcinoma risk in the Caucasian.

A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease

2007 ◽  
Vol 414 (3) ◽  
pp. 282-285 ◽  
Author(s):  
Fabio Coppedè ◽  
Michelangelo Mancuso ◽  
Annalisa Lo Gerfo ◽  
Maria Laura Manca ◽  
Lucia Petrozzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Repair ◽  
Sporadic Alzheimer’S Disease ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Ser326cys Polymorphism
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