Phage tail-like particles are versatile bacterial nanomachines – A mini-review

Highly purified T 5-receptor substance was irradiated with X-rays, and a one-hit dose response was obtained. By comparing quantitatively the results of two independent tests, both of which measure “survival“ of receptor after irradiation, it was possible to conclude that the receptor-active site of one receptor particle must be larger than the cross-section of a T 5-phage tail. However, since receptor particles were never definitely observed to have combined with more than one T 5-particle, secondary processes must be involved in the binding reaction, leading to a rapid inactivation of any surplus receptor-active areas on the receptor particle undergoing the reaction.

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Coordination of cohabiting phage elements supports bacteria–phage cooperation

Nature Communications ◽

10.1038/s41467-019-13296-x ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 12

Author(s):

Tal Argov ◽

Shai Ran Sapir ◽

Anna Pasechnek ◽

Gil Azulay ◽

Olga Stadnyuk ◽

...

Keyword(s):

Listeria Monocytogenes ◽

Bacterial Pathogens ◽

Molecular Switch ◽

Complex Environments ◽

Phage Tail ◽

Bacterial Lysis ◽

Viral Particles ◽

Response To Stress ◽

Insight Into

AbstractBacterial pathogens often carry multiple prophages and other phage-derived elements within their genome, some of which can produce viral particles in response to stress. Listeria monocytogenes 10403S harbors two phage elements in its chromosome, both of which can trigger bacterial lysis under stress: an active prophage (ϕ10403S) that promotes the virulence of its host and can produce infective virions, and a locus encoding phage tail-like bacteriocins. Here, we show that the two phage elements are co-regulated, with the bacteriocin locus controlling the induction of the prophage and thus its activity as a virulence-associated molecular switch. More specifically, a metalloprotease encoded in the bacteriocin locus is upregulated in response to stress and acts as an anti-repressor for CI-like repressors encoded in each phage element. Our results provide molecular insight into the phenomenon of polylysogeny and its intricate adaptation to complex environments.

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Characterization of Serracin P, a Phage-Tail-Like Bacteriocin, and Its Activity against Erwinia amylovora, the Fire Blight Pathogen

Applied and Environmental Microbiology ◽

10.1128/aem.68.11.5704-5710.2002 ◽

2002 ◽

Vol 68 (11) ◽

pp. 5704-5710 ◽

Cited By ~ 54

Author(s):

Abdelhamid Jabrane ◽

Ahmed Sabri ◽

Philippe Compère ◽

Philippe Jacques ◽

Isabel Vandenberghe ◽

...

Keyword(s):

Fire Blight ◽

Erwinia Amylovora ◽

Culture Supernatant ◽

Bacterial Disease ◽

Amino Acid Sequence Analysis ◽

Terminal Amino Acid ◽

Phage Tail ◽

Terminal Amino ◽

Pear Trees

ABSTRACT Serratia plymithicum J7 culture supernatant displayed activity against many pathogenic strains of Erwinia amylovora, the causal agent of the most serious bacterial disease of apple and pear trees, fire blight, and against Klebsiella pneumoniae, Serratia liquefaciens, Serratia marcescens, and Pseudomonas fluorescens. This activity increased significantly upon induction with mitomycin C. A phage-tail-like bacteriocin, named serracin P, was purified from an induced culture supernatant of S. plymithicum J7. It was found to be the only compound involved in the antibacterial activity against sensitive strains. The N-terminal amino acid sequence analysis of the two major subunits (23 and 43 kDa) of serracin P revealed high homology with the Fels-2 prophage of Salmonella enterica, the coliphages P2 and 168, the φCTX prophage of Pseudomonas aeruginosa, and a prophage of Yersinia pestis. This strongly suggests a common ancestry for serracin P and these bacteriophages.

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Inducible Phage Tail-like Particles ofClostridium saccharoperbutylacetonicumand Its Related Strains

Agricultural and Biological Chemistry ◽

10.1080/00021369.1972.10860423 ◽

1972 ◽

Vol 36 (8) ◽

pp. 1413-1421 ◽

Cited By ~ 7

Author(s):

Seiya Ogata ◽

Osamu Mihara ◽

Yoshifumi Ikeda ◽

Motoyoshi Hongo

Keyword(s):

Phage Tail

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