Changes of High Risk HPV (HR HPV) Type Distribution from Atypical Squamous Cells of Undetermined Significance (ASCUS) to High-grade Squamous Intraepithelial Lesion (HSIL)

2014 ◽  
Vol 3 (5) ◽  
pp. S44-S45
Author(s):  
Pradip Manna ◽  
Spencer Kerley ◽  
Paula Clark ◽  
George Ryan ◽  
Greg Scholtz ◽  
...  
Keyword(s):  
High Risk ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Type Distribution ◽  
Squamous Cells ◽  
Intraepithelial Lesion ◽  
High Risk Hpv ◽  
Undetermined Significance

scholarly journals Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ana Cristina Macêdo Barcelos ◽  
Márcia Antoniazi Michelin ◽  
Sheila Jorge Adad ◽  
Eddie Fernando Candido Murta
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Trichomonas Vaginalis ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Squamous Cells ◽  
Hpv Test ◽  
Intraepithelial Lesion ◽  
High Risk Hpv ◽  
Undetermined Significance

Introduction. To analyze patients with atypical squamous cells of undetermined significance (ASCUS) through a cytology review and the presence of microbiological agents, with consideration of colposcopy and semiannual tracking.Methods. 103 women with ASCUS were reviewed and reclassified: normal/inflammatory, ASCUS, low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL). If ASCUS confirmed, it was subclassified in reactive or neoplastic ASCUS, ASC-US, or ASC-H; and Regione Emilia Romagna Screening Protocol. Patients underwent a colposcopic examination, and test forCandidasp., bacterial vaginosis,Trichomonas vaginalis, and human papillomavirus (HPV) were performed.Results. Upon review, ASCUS was diagnosis in 70/103 (67.9%), being 38 (54.2%) reactive ASCUS and 32 (45.71%) neoplastic ASCUS; 62 (88.5%) ASC-US and 8 (11.41%) ASC-H. ASCUS (Regione Protocol), respectively 1-5: 15 (21.4%), 19 (27.1%), 3 (27.1%), 16 (22.8%), and 1 (1.4%). A higher number of cases of cervical intraepithelial neoplasia (CIN) II/III in the biopsies of patients with ASC-H compared to ASC-US (P=.0021). High-risk HPV test and presence of CIN II/III are more frequent in ASC-H than ASC-US (P=.031).Conclusions. ASC-H is associated with clinically significant disease. High-risk HPV-positive status in the triage for colposcopy of patients with ASC-US is associated with increased of CIN.

The Evaluation of p16ink4a Immunoexpression/Immunostaining and Human Papillomavirus DNA Test in Cervical Liquid-Based Cytological Samples

2011 ◽  
Vol 21 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Maria Nasioutziki ◽  
Angelos Daniilidis ◽  
Kostos Dinas ◽  
Maria Kyrgiou ◽  
George Valasoulis ◽  
...  
Keyword(s):  
High Risk ◽  
Hpv Infection ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Dna Test ◽  
Hpv Dna ◽  
Squamous Cells ◽  
Intraepithelial Lesion ◽  
High Risk Hpv ◽  
Hpv Dna Test

Aim:To evaluate the role of p16INK4a immunoexpression and human papillomavirus (HPV) DNA test for the detection of dyskaryotic cells in high-risk women.Materials and Methods:This work was a retrospective diagnostic study conducted in the University Hospital of Thessaloniki from January to December 2008. The subjects were women with current or previous HPV infection and current or previous cervical intraepithelial lesion (with or without treatment) or clinical warts. All liquid-based cytological samples were tested for P16INKa and HPV DNA test. The accuracy parameters used for the outcome included sensitivity, specificity, and positive predictive value.Results:A total of 226 women were included; the mean age was 29 years. Expression of p16INK4a was detected in the cytological samples of 13% of the negative cases, 44% of the cases of atypical squamous cells of undetermined significance, 46% of the cases of low-grade squamous intraepithelial lesion, and 78% of the cases of high-grade squamous intraepithelial lesion. A total of 91 women tested positive for high-risk HPV infection, and 54 of those had p16INK4a-positive staining reaction cells. The concordance between the 2 tests, HPV DNA and p16, was 59% regarding infection-positive cases. Diffuse strong parabasal p16INK4a immunostaining (nuclear score >2) was observed in 17 cases of the abnormal cytological findings (atypical squamous cells of undetermined significance, 2 cases; low-grade squamous intraepithelial lesion, 8 cases; high-grade squamous intraepithelial lesion, 7 cases). Colposcopy-directed biopsies were used as the criterion standard for the detection of cervical intraepithelial neoplasia in 91 women. The sensitivity of p16INK4a was 95% and the specificity was 92%, whereas the sensitivity of high-risk HPV was 100% and the specificity was 78%. The positive predictive value of p16INK4a was 71%, whereas that of HPV DNA was 44%.Conclusion:The findings suggest that p16INK4a immunostaining can improve the accuracy of cytological examination and HPV DNA test and may be particularly useful in the triage of low-grade lesions.

scholarly journals High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus

2019 ◽  
Vol 152 (3) ◽  
pp. 359-364
Author(s):  
Edward B Stelow ◽  
Erik A Dill ◽  
Jonathan J Davick ◽  
Michael B McCabe ◽  
Vanessa M Shami
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Squamous Cell ◽  
Gastroesophageal Junction ◽  
Squamous Cell Carcinomas ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
History Of ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

ABSTRACT Objectives Although the role of human papillomavirus (HPV) in the development of some carcinomas (eg, anogenital and oropharyngeal squamous cell carcinomas) is nondebatable, there is still significant controversy regarding the relationship of HPV and esophageal squamous cell carcinomas (SCCs). Methods All cases were sampled at or near the gastroesophageal junctions in patients with reflux and/or known Barrett esophagus and appear to have been initially sampled “incidentally.” Patients were all men, aged 56 to 80 years. None had a known history of other HPV-related disease. Results We present four cases of high-grade squamous intraepithelial lesion of the gastroesophageal junction secondary to high-risk HPV that have identical histologic features to similar lesions of the anogenital tract. Conclusions Whether such lesions are at risk for developing into invasive SCC remains unclear.

High grade squamous intraepithelial lesion on high-risk HPV negative patients: Why we still need the Pap test

2018 ◽  
Vol 46 (11) ◽  
pp. 908-913 ◽  
Author(s):  
Hongxia Sun ◽  
Ramya P. Masand ◽  
Shobhanaben Jagdishbhai Patel ◽  
Vijayalakshmi Padmanabhan
Keyword(s):  
High Risk ◽  
Pap Test ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion ◽  
High Risk Hpv

scholarly journals Prevalência de anormalidades nos exames citopatológicos realizados no laboratório de análises clínicas da Pontifícia Universidade Católica de Goiás - LC PUC - Goiás

2016 ◽  
Vol 43 (1) ◽  
pp. 27
Author(s):  
Erika Christine Fernandes Kruger ◽  
Sara Anna Chaves Chan ◽  
Andrea Alves Ribeiro
Keyword(s):  
Odds Ratio ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Squamous Cells ◽  
Intraepithelial Lesion ◽  
Undetermined Significance

Resumo: O câncer do colo do útero possui alta incidência no Brasil. O objetivo foi estimar a prevalência de anormalidades citológicas nos exames citopatológicos e verificar a associação entre as anormalidades citológicas em dois grupos etários. Este estudo foi realizado no Laboratório de Análises Clínicas da Pontifícia Universidade Católica de Goiás (LC PUC-GO) no período de Janeiro a dezembro de 2013, em um modelo estratificado por faixa etária: 14-19 anos, 20-29 anos, 30-39 anos, 40-49 anos, 50-59 anos, 60-69 anos, e maiores que 70 anos, para o cálculo da prevalência. Para a análise estatística da associação entre as variáveis as lesões foram categorizadas em: menos graves: Atypical squamous cells of undetermined significance e Low grade squameus intraepithelial lesion (ASC-US e LSIL) e mais graves: Atypical squamous cells of undetermined significance cannot exclude high grade squamous intraepithelial lesion, High grade squamous intraepithelial lesion, Atypical endocervical cells, favor neoplastic (ASC-H, HSIL, AGC-NEO) e a faixa etária subdividida em 14-29 anos e maior ou igual a 30 anos para o cálculo do Odds Ratio (OR), considerando um intervalo de confiança (IC) de 95% e valor p < 0,05. Foram analisados 2.183 laudos de exames citopatológicos, destes 2.174 classificados como satisfatórios 99,59% (2.174/2.183) e 0,41% (9/2183) insatisfatórios para análise. A prevalência dos resultados negativos foi de 89,74% (1959/2183) e de resultados com anormalidades citológicas foi de 9,85% (215/2183). Na faixa etária de 20 a 29 anos, observou-se um total de 0,46% (10/2174) de LSIL e 0,41% (9/2174) de HSIL, de 30 a 39 anos foram observados 1,05% (23/2174) de ASC-H e na entre 40 a 49 de 0,92% (20/2174) de ASC-H. Mulheres com idade igual ou acima de 30 anos mostraram associação estatisticamente significante (OR: 2,79 IC 95%: 1,50-5,21 p < 0,004). Conclui-se que as anormalidades foram mais prevalentes em mulheres acima de 30 anos. Palavras-Chave: Câncer do colo do útero. Esfregaços cervicais. Neoplasia intraepitelial

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