scholarly journals A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

2021 ◽  
Vol 296 ◽  
pp. 100485
Author(s):  
Natalie M. Garza ◽  
Aaron T. Griffin ◽  
Mohammad Zulkifli ◽  
Chenxi Qiu ◽  
Craig D. Kaplan ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Mitochondrial Cytochrome ◽  
Genome Wide ◽  
A Genome ◽  
Mitochondrial Cytochrome C

Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD50yields insight into the efficacy of prophylactics

2011 ◽  
Vol 33 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Mandy L. Marziaz ◽  
Kathryn Frazier ◽  
Paul B. Guidry ◽  
Robyn A. Ruiz ◽  
Ilona Petrikovics ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Oxidase Activity ◽  
Mitochondrial Cytochrome ◽  
Insight Into ◽  
Mitochondrial Cytochrome C

Copper supplementation restores cytochrome c oxidase activity in cultured cells from patients with SCO2 mutations

2002 ◽  
Vol 363 (2) ◽  
pp. 321-327 ◽  
Author(s):  
Leonardo SALVIATI ◽  
Evelyn HERNANDEZ-ROSA ◽  
Winsome F. WALKER ◽  
Sabrina SACCONI ◽  
Salvatore DiMAURO ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Growth Medium ◽  
Oxidase Activity ◽  
Cultured Cells ◽  
Binding Protein ◽  
Mitochondrial Cytochrome ◽  
Copper Supplementation ◽  
In Cells ◽  
Mitochondrial Cytochrome C

Human SCO2 is a nuclear-encoded Cu-binding protein, presumed to be responsible for the insertion of Cu into the mitochondrial cytochrome c oxidase (COX) holoenzyme. Mutations in SCO2 are associated with cardioencephalomyopathy and COX deficiency. Studies in yeast and bacteria have shown that Cu supplementation can restore COX activity in cells harbouring mutations in genes involving Cu transport. Therefore we investigated whether Cu supplementation could restore COX activity in cultured cells from patients with SCO2 mutations. Our data demonstrate that the COX deficiency observed in fibroblasts, myoblasts and myotubes from patients with SCO2 mutations can be restored to almost normal levels by the addition of CuCl2 to the growth medium.

Uranium inhibits mammalian mitochondrial cytochrome c oxidase and ATP synthase

2021 ◽  
Vol 271 ◽  
pp. 116377
Author(s):  
Libing Yu ◽  
Wenjing Li ◽  
Jian Chu ◽  
Chun Chen ◽  
Xijian Li ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Atp Synthase ◽  
Mitochondrial Cytochrome ◽  
Mitochondrial Cytochrome C
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