Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)2Cys6 transcriptional activator and induced by kojic acid at the transcriptional level

2011 ◽  
Vol 112 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Junichiro Marui ◽  
Noriko Yamane ◽  
Sumiko Ohashi-Kunihiro ◽  
Tomohiro Ando ◽  
Yasunobu Terabayashi ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Kojic Acid ◽  
Transcriptional Activator ◽  
Transcriptional Level ◽  
Acid Biosynthesis

Overexpression of a novel gene Aokap2 affects the growth and kojic acid production in Aspergillus oryzae

2022 ◽  
Author(s):  
Yuzhen Li ◽  
Huanxin Zhang ◽  
Ziming Chen ◽  
Junxia Fan ◽  
Tianming Chen ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Acid Production ◽  
Kojic Acid ◽  
Novel Gene ◽  
Kojic Acid Production

Cadmium regulates copper homoeostasis by inhibiting the activity of Mac1, a transcriptional activator of the copper regulon, in Saccharomyces cerevisiae

2010 ◽  
Vol 431 (2) ◽  
pp. 257-265 ◽  
Author(s):  
Dong-Hyuk Heo ◽  
In-Joon Baek ◽  
Hyun-Jun Kang ◽  
Ji-Hyun Kim ◽  
Miwha Chang ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Molecular Mechanisms ◽  
Cadmium Toxicity ◽  
Toxic Metal ◽  
Copper Metabolism ◽  
Transcriptional Activator ◽  
Northern Blotting ◽  
Model Systems ◽  
Transcriptional Level ◽  
Mechanisms Of Toxicity

Cadmium is a toxic metal and the mechanism of its toxicity has been studied in various model systems from bacteria to mammals. We employed Saccharomyces cerevisiae as a model system to study cadmium toxicity at the molecular level because it has been used to identify the molecular mechanisms of toxicity found in higher organisms. cDNA microarray and Northern blot analyses revealed that cadmium salts inhibited the expression of genes related to copper metabolism. Western blotting, Northern blotting and chromatin immunoprecipitation experiments indicated that CTR1 expression was inhibited at the transcriptional level through direct inhibition of the Mac1 transcriptional activator. The decreased expression of CTR1 results in cellular copper deficiency and inhibition of Fet3 activity, which eventually impairs iron uptake. In this way, cadmium exhibits a negative effect on both iron and copper homoeostasis.

Aspergillus oryzae NRRL 35191 from coffee, a non-toxigenic endophyte with the ability to synthesize kojic acid

2011 ◽  
Vol 11 (1) ◽  
pp. 263-267 ◽  
Author(s):  
Fabio C. Chaves ◽  
Thomas J. Gianfagna ◽  
Madhu Aneja ◽  
Francisco Posada ◽  
Stephen W. Peterson ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Kojic Acid

Improvement of production of Kojic acid by a mutant strain Aspergillus oryzae, MK107-39

2001 ◽  
Vol 91 (3) ◽  
pp. 272-276 ◽  
Author(s):  
Takafumi Futamura ◽  
Mitsuyasu Okabe ◽  
Takayoshi Tamura ◽  
Kyouko Toda ◽  
Toshio Matsunobu ◽  
...  
Keyword(s):  
Mutant Strain ◽  
Aspergillus Oryzae ◽  
Kojic Acid
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