Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy

2019 ◽  
Vol 13 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Ki-Bum Won ◽  
Sang-Eun Lee ◽  
Byoung Kwon Lee ◽  
Hyung-Bok Park ◽  
Ran Heo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Computed Tomography Angiography ◽  
Coronary Plaque ◽  
Computed Tomographic Angiography ◽  
Longitudinal Assessment ◽  
Plaque Volume ◽  
Glycemic Status ◽  
Computed Tomographic ◽  
Tomographic Angiography ◽  
Coronary Plaque Volume

scholarly journals Changes in Coronary Plaque Volume: Comparison of Serial Measurements on Intravascular Ultrasound and Coronary Computed Tomographic Angiography

2018 ◽  
Vol 45 (2) ◽  
pp. 84-91 ◽  
Author(s):  
Rine Nakanishi ◽  
Anas Alani ◽  
Suguru Matsumoto ◽  
Dong Li ◽  
Michael Fahmy ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intravascular Ultrasound ◽  
Coronary Plaque ◽  
Computed Tomographic Angiography ◽  
Plaque Volume ◽  
Coronary Computed Tomography ◽  
Computed Tomographic ◽  
Tomographic Angiography ◽  
Serial Measurements ◽  
Coronary Plaque Volume

Serial measurements of coronary plaque volume have been used to evaluate drug efficacy in atherosclerotic progression. However, the usefulness of computed tomography for this purpose is unknown. We investigated whether the change in total plaque volume on coronary computed tomographic angiography is associated with the change in segment plaque volume on intravascular ultrasound. We prospectively enrolled 11 consecutive patients (mean age, 56.3 ± 5 yr; 6 men) who were to undergo serial invasive coronary angiographic examinations with use of grayscale intravascular ultrasound and coronary computed tomography, performed <180 days apart at baseline and from 1 to 2 years later. Subjects underwent 186 serial measurements of total plaque volume on coronary computed tomography and 22 of segmental plaque volume on intravascular ultrasound. We used semiautomated software to examine percentage relationships and changes between total plaque and segmental plaque volumes. No significant correlations were found between percentages of total coronary and segment coronary plaque volume, nor between normalized coronary plaque volume. However, in the per-patient analysis, there were strong correlations between the imaging methods for changes in total coronary and segment coronary plaque volume (r=0.62; P=0.04), as well as normalized plaque volume (r=0.82; P=0.002). Per-patient change in plaque volume on coronary computed tomography is significantly associated with that on intravascular ultrasound. Computed tomographic angiography may be safer and more widely available than intravascular ultrasound for evaluating atherosclerotic progression in coronary arteries. Larger studies are warranted.

P3380Longitudinal assessment of coronary atherosclerosis according to baseline and changes of serum hemoglobin level

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
K.-B Won ◽  
B K Lee ◽  
A Rizvi ◽  
M Hadamitzky ◽  
M J Budoff ◽  
...  
Keyword(s):  
Coronary Plaque ◽  
Computed Tomographic Angiography ◽  
Hemoglobin Level ◽  
Plaque Volume ◽  
Computed Tomographic ◽  
Group I ◽  
Tomographic Angiography ◽  
Coronary Plaque Volume ◽  
Baseline Hemoglobin

Abstract Introduction Little is known regarding the impact of serum hemoglobin level changes (Δ hemoglobin) on coronary plaque volume. This study evaluated the association between Δ hemoglobin and coronary plaque volume change (PVC) using serial coronary computed tomographic angiography (CCTA). Methods A total of 830 subjects (61±10 years, 51.9% male) who underwent serial CCTA with available hemoglobin levels were analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.5 to 4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into four groups based on the quartile of baseline hemoglobin levels. Annualized PVC was defined as total PVC divided by inter-scan period. Plaque progression (PP) was defined as plaque volume at follow-up minus plaque volume at index >0. Results Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 (0.0–127.4) vs. group II: 28.8 (0.0–123.0) vs. group III: 49.9 (5.6–135.0) vs. group IV [highest]: 34.3 (0.0–130.7); p=0.235). During follow-up, Δ hemoglobin was related to annualized PVC (β:−0.114; p=0.001) and PP (odds ratio: 0.868; 95% confidence interval: 0.770–0.978; p=0.020). Multiple linear regression models showed that Δ hemoglobin significantly impacted on annualized PVC in only the composite of I and II groups. Conclusion Based on serial CCTA findings, Δ hemoglobin independently impacted on coronary PVC in individuals with low to normal baseline hemoglobin level.

Computed tomographic angiography in stroke and high-risk transient ischemic attack: Do not leave the emergency department without it!

2018 ◽  
Vol 13 (7) ◽  
pp. 673-686
Author(s):  
Brett R Graham ◽  
Bijoy K Menon ◽  
Shelagh B Coutts ◽  
Mayank Goyal ◽  
Andrew M Demchuk
Keyword(s):  
Computed Tomography ◽  
Computed Tomography Angiography ◽  
Hemorrhagic Stroke ◽  
Computed Tomographic Angiography ◽  
Rapid Diagnosis ◽  
Vascular Lesions ◽  
Transient Ischemic Attacks ◽  
Computed Tomographic ◽  
Ischemic Attack ◽  
Tomographic Angiography

Stroke is a major cause of morbidity and mortality worldwide, and effective treatment requires rapid diagnosis and recognition of relevant vascular lesions. In this review we will discuss the usefulness and versatility of computed tomography angiography in the setting of stroke, be it ischemic or hemorrhagic, minor or disabling. Furthermore, we also highlight how we use computed tomography angiography in decision making in transient ischemic attacks, acute disabling ischemic stroke, and hemorrhagic stroke.

Quantified coronary total plaque volume from computed tomography angiography provides superior 10-year risk stratification

2020 ◽  
Author(s):  
Simon Deseive ◽  
Maximilian Kupke ◽  
Ramona Straub ◽  
Thomas J Stocker ◽  
Alexander Broersen ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Computed Tomographic Angiography ◽  
Study Endpoint ◽  
Plaque Volume ◽  
Coronary Cta ◽  
Computed Tomographic ◽  
Coronary Syndrome ◽  
Coronary Artery Disease Severity ◽  
Net Reclassification Improvement ◽  
Tomographic Angiography

Abstract Aims  Automated coronary total plaque volume (TPV) quantification derived from coronary computed tomographic angiography (CTA) datasets provide exact and reliable assessment of calcified and non-calcified coronary atherosclerosis burden. The aim of this analysis was to investigate the long-term predictive value of TPV. Methods and results  TPV was quantified in 1577 patients undergoing coronary CTA and cardiovascular events were collected during 10.5 years (interquartile range 6.0–11.4) of follow-up. The study endpoint comprised cardiac death and acute coronary syndrome and occurred in 59 (3.7%) patients. Coronary TPV provided additive prognostic value over clinical risk assessed with the Morise Score and coronary artery disease severity (rise in C-index from 0.744 to 0.769, P = 0.03). A category-based reclassification approach combining the Morise Score and TPV revealed superior risk stratification (categorical net reclassification improvement: 0.48 with 95% CI 0.13–0.68, P < 0.001) and resulted in reclassification of 800 (51%) patients compared with the Morise Score alone. The 10-year risk for the study endpoint was 0.6% (95% CI 0–1.3) for patients classified as low risk (n = 807), 4.8% (95% CI 2.4–7.2) for patients at intermediate risk (n = 400), and 10.3% (95% CI 6.6–13.9) for patients at high risk (n = 370) using the combined reclassification approach. Conclusion  Quantification of TPV from coronary CTA permits an improved 10-year cardiovascular risk stratification.

Sign in / Sign up

Export Citation Format

Share Document