Aptamer-based Immunoaffinity LC-MS using an Ultra-short Column for Rapid Attomole Level Quantitation of Intact mAbs

2021 ◽  
pp. 122694
Author(s):  
Jennifer M. Nguyen ◽  
Xiaoxiao Liu ◽  
Maureen DeLoffi ◽  
Amarande Murisier ◽  
Szabolcs Fekete ◽  
...  
Keyword(s):  
2018 ◽  
Vol 7 (3) ◽  
pp. 1376
Author(s):  
N Chaitanya ◽  
V Ranga Rao ◽  
M Achyutha Kumar Reddy

The purpose of this paper is to compare the behaviour of composite reinforced concrete square short columns and conventional square short column. Experiments are conducted on four axially loaded column specimens till failure. Among four specimens, two are conventional and remaining two columns are having equal angles as main reinforcement. Short columns are designed using IS 456 2000. The obtained details of main reinforcement are replaced in area wise by equal angle (ISA 2525). The tie reinforcement used to withhold the main reinforcement in position are retained with the same deformed bars. Performance of columns are measured in terms of load carrying capacity, longitudinal strain, stress, crushing modes, strains in each face using strain gauges. Outcome of the experiments are compared and plotted in the form of stress vs strain of the column. A finite element model was developed using Abaqus to simulate the results.  


2019 ◽  
Vol 30 (6) ◽  
pp. 539-543
Author(s):  
Mahmoud Badran ◽  
Osama Farouk ◽  
Ayman Kamal ◽  
Hossam Abubeih ◽  
Mohamed Khaled

2006 ◽  
Vol 19 (13) ◽  
pp. 1393-1396 ◽  
Author(s):  
W. Aliaga ◽  
C.H. Sampaio ◽  
I.A.S. Brum ◽  
K.R.S. Ferreira ◽  
M.A. Batistella

Author(s):  
Alexandria M. Carolan ◽  
J. Brian Hall ◽  
Stephen K. Longwell ◽  
F. Arzu Alpan ◽  
Gregory M. Imbrogno ◽  
...  

Abstract As plants apply for 80 year licensure (subsequent license renewal), the United States Nuclear Regulatory Commission (U.S. NRC) has queried the nuclear power plant industry to investigate the impact of neutron embrittlement (radiation effects) on the reactor pressure vessel (RPV) structural steel supports due to extended plant operation past 60 years. The radiation effects on RPV supports were previously investigated and resolved as part of Generic Safety Issue No. 15 (GSI-15) in NUREG-0933 Revision 3 [1], NUREG-1509 [2] (published in May 1996), and NUREG/CR-5320 [3] (published in January 1989) for design life (40 years) and for first license renewal (20 additional years). The conclusions in NUREG-0933, Revision 3 stated that there were no structural integrity concerns for the RPV support structural steels; even if all the supports were totally removed (i.e. broken), the piping has acceptable margin to carry the load of the vessel. Nevertheless, for plants applying for 80 year life licensure, the U.S. NRC has requested an evaluation to show structural integrity of the RPV supports by accounting for radiation embrittlement (radiation damage) for continued operation into the second license renewal period (i.e. 80 years). The RPV support designs in light water reactors are grouped into one of five categories or types of supports: (1) skirt; (2) long-column; (3) shield-tank; (4) short column; and (5) suspension. In this paper, two of these RPV support configurations (short column supports and neutron shield tank) will be investigated using fracture mechanics to evaluate the effect of radiation embrittlement of the structural steel supports for long term operations (i.e. 80 years). The technical evaluation of other support configurations will be provided in a separate technical publication at a future date.


2020 ◽  
Vol 30 ◽  
pp. 101232 ◽  
Author(s):  
P. Saranya ◽  
Praveen Nagarajan ◽  
A.P. Shashikala

1992 ◽  
Vol 20 (2) ◽  
pp. 116-118 ◽  
Author(s):  
O.P. Malhotra ◽  
Prakash Prabhakar ◽  
Arvind M. Kayastha
Keyword(s):  

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