scholarly journals CRT-200.49 Hypoxic Liver Injury Diagnosed in the Emergency Room Predicts In-Hospital Death in Patients With Acute ST-segment Elevation Myocardial Infarction

2016 ◽  
Vol 9 (4) ◽  
pp. S18
Author(s):  
Jon Suh ◽  
Sang-Ho Park ◽  
Ho-Jun Jang ◽  
Tae-Hoon Kim ◽  
Sung Woo Kwon ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Liver Injury ◽  
Emergency Room ◽  
Hospital Death ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Hypoxic Liver Injury

Assessment of early administration of abciximab in acute ST-segment elevation myocardial infarction in the emergency room

2006 ◽  
Vol 35 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Amandine Arhan ◽  
Patrick Ecollan ◽  
Béatrice Madonna-Py ◽  
Julie Kergueno ◽  
Mohammed Bennaceur ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Emergency Room ◽  
Early Administration ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

scholarly journals Use of the Thrombolysis in Myocardial Infarction Risk Index for Elderly Patients With ST-Segment Elevation Myocardial Infarction

2021 ◽  
Vol 8 ◽  
Author(s):  
Bingqi Fu ◽  
Xuebiao Wei ◽  
Qi Wang ◽  
Zhiwen Yang ◽  
Jiyan Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Elderly Patients ◽  
Assessment Tool ◽  
Risk Index ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Hospital Death ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

Background: Thrombolysis in Myocardial Infarction (TIMI) Risk Index (TRI) is a simple risk assessment tool for patients with ST-segment elevation myocardial infarction (STEMI). However, its applicability to elderly patients with STEMI undergoing percutaneous coronary intervention (PCI) is uncertain.Methods: This was a retrospective analysis of elderly (≥60 years) patients who underwent PCI for STEMI from January 2010 to April 2016. TRI was calculated on admission using the following formula: heart rate × (age/10)2/systolic blood pressure. Discrimination and calibration of TRI for in-hospital events and 1 year mortality were analyzed.Results: Totally 1,054 patients were divided into three groups according to the tertiles of the TRI: <27 (n = 348), 27–36 (n = 360) and >36 (n = 346). The incidence of acute kidney injury (AKI; 7.8 vs. 8.6 vs. 24.0%, p < 0.001), AHF (3.5 vs. 6.6 vs. 16.2%, p < 0.001), in-hospital death (0.6 vs. 3.3 vs. 11.6%, p < 0.001) and MACEs (5.2 vs. 5.8 vs. 15.9%, p < 0.001) was significantly higher in the third tertile. TRI showed good discrimination for in-hospital death [area under the curve (AUC) = 0.804, p < 0.001; Hosmer-Lemeshow p = 0.302], which was superior to its prediction for AKI (AUC = 0.678, p < 0.001; Hosmer-Lemeshow p = 0.121), and in-hospital MACEs (AUC = 0.669, p < 0.001; Hosmer-Lemeshow p = 0.077). Receiver-operation characteristics curve showed that TRI > 42.0 had a sensitivity of 64.8% and specificity of 82.2% for predicting in-hospital death. Kaplan-Meier analysis showed that patients with TRI > 42.0 had higher 1 year mortality (Log-rank = 79.2, p < 0.001).Conclusion: TRI is suitable for risk stratification in elderly patients with STEMI undergoing PCI, and is thus of continuing value for an aging population.

scholarly journals The prognostic value of MELD-XI in elderly patients with ST-segment elevation myocardial infarction: an observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Song-jian He ◽  
Jian-xin Weng ◽  
Hai-jun Chen ◽  
Hua-qiu Li ◽  
Wen-qin Guo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Risk Assessment ◽  
Elderly Patients ◽  
Risk Score ◽  
Prognostic Value ◽  
Hospital Death ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Timi Risk Score

Abstract Background The model for end-stage liver disease excluding international normalized ratio (MELD-XI) is a simple score for risk assessment. However, the prognostic role of MELD-XI and its additional value to current risk assessment in elderly patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) is uncertain. Methods In all, 1029 elderly patients with STEMI undergoing PCI were consecutively included and classified into three groups according to the TIMI risk score: low-risk (≤ 3, n = 251); moderate-risk (4–6, n = 509); and high-risk (≥ 7, n = 269) groups. Multivariate analysis was performed to identify risk factors for adverse events. Results The overall in-hospital mortality was 5.3% and was significantly higher in the high-risk group (1.2% vs. 3.3% vs. 13.0%, p < 0.001). The optimal cut-off of the TIMI risk score and MELD-XI for in-hospital death was 7 and 13, respectively. MELD-XI was associated with in-hospital (adjusted odds ratio = 1.09, 95% CI = 1.04–1.14, p = 0.001) and one-year (adjusted hazard ratio = 1.05, 95% CI = 1.01–1.08, p = 0.005) mortality independently of the TIMI risk score. Combining TIMI risk score and MELD-XI exhibited better predictive power for in-hospital death than TIMI risk score (area under the curve [AUC] = 0.810 vs. 0.753, p = 0.008) or MELD-XI alone (AUC = 0.810 vs. 0.750, p = 0.018). Patients with TIMI risk score ≥ 7 and MELD-XI ≥ 13 had the worst prognosis. Conclusion MELD-XI could be considered as a risk-stratified tool for elderly patients with STEMI undergoing PCI. It had an additive prognostic value to TIMI risk score.

scholarly journals Correlation between body mass index and in-hospital mortality in patients with ST-segment elevation myocardial infarction in Erbil city- Iraq

2021 ◽  
Vol 21 (1) ◽  
pp. 35-43
Author(s):  
Azad Ahmed Abdullah ◽  
◽  
Salam Naser Zangana
Keyword(s):  
Myocardial Infarction ◽  
Body Mass Index ◽  
Hospital Mortality ◽  
Body Mass ◽  
Hospital Death ◽  
St Segment Elevation ◽  
Acute Stemi ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Significant Difference

Background: Although High body mass index is associated with many cardiovascular diseases including coronary artery disease. Its effect on in-hospital death in patients with acute ST-segment elevation myocardial infarction (STEMI) is still a subject of controversy. Objective: To determine the correlation between body mass index (BMI) and in-hospital mortality in those patients. Patients and Methods: In this cross-sectional study, 180 adult patients with acute STEMI were enrolled and their BMI was measured. The participants were classified according to BMI into three groups as normal, overweight, and obese. A correlation between in-hospital mortality due to STEMI and BMI was evaluated. Results: Of the total participants, 62 (34.4%) were normally weighted, 61(33.8%) were over-weighted, and 57(31.6%) were obese. There was a significant difference (p= <0.001) between the groups concerning troponin I, hs-CRP, GRACE score, and the probability of in-hospital death. There were 16 (8.8%) in-hospital deaths during the study distributed as follows; 1(1.6%) in the normal-weight group, 5(8.1%) in the overweight group, and 10 (17.5%) in the obese group. In-hospital death showed a significant difference (p=0.04) between the study groups. In addition, a significant positive correlation(r=0.9) was found between BMI and in-hospital death. Conclusion: A robust positive correlation was detected between BMI and in-hospital mortality due to acute STEMI. When BMI increases, the number of deaths also increases exponentially. Keywords: Body mass index, ST-segment elevation myocardial infarction, mortality

scholarly journals A Novel Predictive Model for In-Hospital Mortality Based on a Combination of Multiple Blood Variables in Patients with ST-Segment-Elevation Myocardial Infarction

2020 ◽  
Vol 9 (3) ◽  
pp. 852
Author(s):  
Yuhei Goriki ◽  
Atsushi Tanaka ◽  
Kensaku Nishihira ◽  
Atsushi Kawaguchi ◽  
Masahiro Natsuaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Hospital Mortality ◽  
Risk Score ◽  
Troponin I ◽  
Hospital Death ◽  
St Segment Elevation ◽  
Derivation Cohort ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Significant Difference

In emergency clinical settings, it may be beneficial to use rapidly measured objective variables for the risk assessment for patient outcome. This study sought to develop an easy-to-measure and objective risk-score prediction model for in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI). A total of 1027 consecutive STEMI patients were recruited and divided into derivation (n = 669) and validation (n = 358) cohorts. A risk-score model was created based on the combination of blood test parameters obtained immediately after admission. In the derivation cohort, multivariate analysis showed that the following 5 variables were significantly associated with in-hospital death: estimated glomerular filtration rate <45 mL/min/1.73 m2, platelet count <15 × 104/μL, albumin ≤3.5 g/dL, high-sensitivity troponin I >1.6 ng/mL, and blood sugar ≥200 mg/dL. The risk score was weighted for those variables according to their odds ratios. An incremental change in the scores was significantly associated with elevated in-hospital mortality (p < 0.001). Receiver operating characteristic curve analysis showed adequate discrimination between patients with and without in-hospital death (derivation cohort: area under the curve (AUC) 0.853; validation cohort: AUC 0.879), and there was no significant difference in the AUC values between the laboratory-based and Global Registry of Acute Coronary Events (GRACE) score (p = 0.721). Thus, our laboratory-based model might be helpful in objectively and accurately predicting in-hospital mortality in STEMI patients.

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