PLGA-PEG-PLGA triblock copolymeric micelles as oral drug delivery system: In vitro drug release and in vivo pharmacokinetics assessment

2017 ◽  
Vol 490 ◽  
pp. 542-552 ◽  
Author(s):  
Xiufen Chen ◽  
Jianzhong Chen ◽  
Bowen Li ◽  
Xiang Yang ◽  
Rongjie Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
In Vitro Drug Release ◽  
Oral Drug Delivery System ◽  
In Vivo Pharmacokinetics

Novel Insulin Thiomer Nanoparticles: In Vivo Evaluation of an Oral Drug Delivery System

2008 ◽  
Vol 9 (1) ◽  
pp. 278-285 ◽  
Author(s):  
Britta Deutel ◽  
Melanie Greindl ◽  
Michael Thaurer ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
In Vivo Evaluation ◽  
Oral Drug Delivery System

scholarly journals Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery

2015 ◽  
Vol 14 (1) ◽  
pp. 17-27 ◽  
Author(s):  
MA Momoh ◽  
FC Kenechukwu ◽  
MS Gwarzo ◽  
PF Builders
Keyword(s):  
Drug Delivery ◽  
Encapsulation Efficiency ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
In Vitro Drug Release ◽  
Alternative Drug ◽  
Anti Inflammatory ◽  
Low Solubility

Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for in vitro and in vivo performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and in vitro drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%) of 89.4 and 97.9% were obtained for lipospheres A1 and A3, respectively. Stable, spherical and smooth lipospheres of size range 101 ± 0.30 to 178 ± 0.30 ?m were obtained. Minimum and maximum release of 75 and 96.9% were obtained for A1 and A3, respectively. Significant (p<0.005) analgesic and anti-inflammatory activities were achieved with prolong plasma concentration. IBU-lipospheres based on beeswax and phospholipid could be explored as an alternative drug delivery system.Dhaka Univ. J. Pharm. Sci. 14(1): 17-27, 2015 (June)

scholarly journals Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

RSC Advances ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 5372-5380 ◽  
Author(s):  
Soledad Stagnoli ◽  
M. Alejandra Luna ◽  
Cristian C. Villa ◽  
Fabrisio Alustiza ◽  
Ana Niebylski ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Catanionic Surfactant ◽  
Catanionic Vesicles ◽  
System P ◽  
Oral Drug Delivery System

We evaluatein vitroandin vivotoxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant AOT-BHD in order to investigate their potential application as an oral drug delivery system.

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