Results of an International Corneal Confocal Microscopy (CCM) Consortium: A Pooled Multicentre Analysis of the Concurrent Diagnostic Validity of CCM to Identify Diabetic Polyneuropathy in Type 2 Diabetes Mellitus

2016 ◽  
Vol 40 (5) ◽  
pp. S73
Author(s):  
Bruce A. Perkins ◽  
Leif E. Lovblom ◽  
Vera Bril ◽  
Katie Edwards ◽  
Nicola Pritchard ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Confocal Microscopy ◽  
Diabetic Polyneuropathy ◽  
Diagnostic Validity ◽  
Corneal Confocal Microscopy

scholarly journals In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes

2021 ◽  
Author(s):  
Noémi Tóth ◽  
David M. Silver ◽  
Szabolcs Balla ◽  
Miklós Káplár ◽  
Adrienne Csutak
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Optical Coherence Tomography ◽  
Type 2 Diabetes Mellitus ◽  
Confocal Microscopy ◽  
Nerve Fibers ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve

Abstract Purposes To examine corneal nerve and retinal nerve characteristics of participants with type 2 diabetes mellitus (T2DM) compared with obese participants without diabetes to discover potential nerve vulnerabilities. Methods All participants underwent a complete medical examination including a physical examination and blood sample tests. The ophthalmologic examination included best-corrected visual acuity, intraocular pressure, Schirmer test, tear film breakup time, slit-lamp examination, dilated fundus photography, in vivo corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT). Results The study cohort consisted of 83 eyes of 83 individuals: a group of 44 participants with T2DM, and a control group of 39 obese participants with no history of diabetes. Comparing measurements on the two groups, participants with T2DM had lower values with statistical significance for retinal nerve fiber layer (RNFL) nasal superior thickness (p = 0.010) and three corneal nerve (CN) parameters: fiber length (p = 0.025), total branch density (p = 0.013), and fiber area (p = 0.009). There was a borderline significant difference in CN fiber width (p = 0.051) and RNFL nasal inferior thickness (p = 0.056). No other significant differences were observed in the IVCCM and OCT parameters. No statistically significant correlation was found between CN and RNFL parameters. Conclusions Progression from a pre-diabetic obese state to a T2DM condition might entail a loss or diminishment of certain corneal nerve fibers or retinal nerve fibers, but not necessarily a loss of both corneal and retinal nerve fibers simultaneously. Using IVCCM and OCT together enables monitoring of both corneal and retinal health of the eye.

scholarly journals Experience in using nucleotides for the management Of patients with diabetic polyneuropatie

2018 ◽  
pp. 24-28
Author(s):  
G. N. Belskaya ◽  
L. G. Krylova ◽  
L. A. Sergienko ◽  
S. B. Stepanova ◽  
L. D. Makarova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Polyneuropathy ◽  
Control Group ◽  
Basic Therapy ◽  
Neuropathic Symptom ◽  
Study Results ◽  
Diabetes Mellitus Management

Diabetic polyneuropathy (DPN) is one of the most common complications of diabetes mellitus. Management of patients with DPN is a complex medical and socioeconomic problem. The article presents the observational study results of 40 patients with type 2 diabetes mellitus complicated by DPN. Patients of the treatment group received Keltikan® complex in combination with basic therapy for 60 days, patients of the control group received only basic therapy. The treatment resulted in the positive changes observed in both groups, while the group taking Keltikan® complex showed more pronounced changes according to the total neurological symptoms (TSS) scale, the neuropathic dysfunctional score (NDS) scale, the neuropathic symptom score (NSS) scale, and also according to the electroneuromyography results. 

scholarly journals Psychoneurologic characteristics of patients with type 2 diabetes mellitus and diabetic polyneuropathy

2010 ◽  
Vol 13 (4) ◽  
pp. 39-41
Author(s):  
Natalya Alexandrovna Belyakova ◽  
Daria Gennad'evna Mikhaylova ◽  
Inna Gennad'evna Tsvetkova ◽  
Svetlana Alekseevna Gorbacheva ◽  
Alexander L'vovich Startsev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Symptoms ◽  
Diabetic Polyneuropathy ◽  
Late Complications ◽  
Psychological Status ◽  
Peripheral Polyneuropathy ◽  
Personal Anxiety

Aim. To study psychologic and neurologic characteristics and their interrelationship in patients with type 2 diabetes mellitus (DM). Materials and methods. The study included 167 women aged 54.2?0.4 years with DM2 9.9?0.51 years in duration. Severity of DM was estimatedfrom the presence of late complications and labile clinical course of the disease. Diabetic peripheral polyneuropathy was diagnosed basedon clinical symptoms, NSS and NDS scales. The psychological status was studied by the Spielberger-Khanin method with the assessment of reactive(situational (PX-1) and personal (PX-2) anxiety. Results. Most CD2 patients presented with moderate (NDS) and severe (NSS) polyneuropathy. It became aggravated as DM duration increased,with subjective symptomatics prevailing over objective one. The psychologic status of the patients was characterized by moderate depression andfrequent anxiety episodes in which personal anxiety prevailed over situational one. The latter was associated with macroangiopathy and thelatter with severe polyneuropathy. Depression most frequently occurred in patients with CHD, obesity, and decompensated carbohydrate metabolism. Conclusion. The above peculiarities of psychologic and neurologic status of DM2 patients should be taken into account when planning their outandinpatient treatment and education.

scholarly journals The sexual function of peri- and post-menopausal women presenting with type 2 diabetes mellitus

2012 ◽  
Vol 58 (1) ◽  
pp. 29-33
Author(s):  
A S Pogorelova ◽  
T Iu Berketova ◽  
G A Mel'nichenko ◽  
A K Ragozin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Hba1c Level ◽  
Diabetic Polyneuropathy ◽  
Post Menopausal

The objective of the present work was to estimate the influence of the compensation of type 2 diabetes mellitus (DM2) and its late complications on the sexual function of the women presenting with type 2 diabetes mellitus during the peri- and post-menopausal periods. The sexual function was studied in 368 women with DM2 and in 314 ones without disturbances of carbohydrate metabolism (controls) using the Women's Sexual Function Questionnaire developed by F.H. Quirk in 2002. The prevalence of sexual dysfunction in the groups of DM2 women and controls was estimated at 52.2% and 30.9% respectively (p<0.001). The women with DM2 reported the lower quality of intimate relationships with the partner (p = 0.003) and lower satisfaction with the sexual quality of life (p=0.007) compared with the control respondents. The risk of sexual dysfunction in the women with type 2 diabetes mellitus increased by 2.4 times (p<0.001), in those with diabetic polyneuropathy by 4.8 times, and in the women with the blood glycated hemoglobin (HbA1c) level in excess of 7.0% by 2.3 times (p=0.012). It is concluded that type 2 diabetes mellitus is an independent risk factor of sexual dysfunction during the peri- and post-menopausal periods. Other risk factors are constituted by diabetic polyneuropathy and elevated HbA1c level (>7.0%).

Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark

2018 ◽  
Vol 32 (12) ◽  
pp. 1153-1159 ◽  
Author(s):  
Signe T. Andersen ◽  
Kasper Grosen ◽  
Hatice Tankisi ◽  
Morten Charles ◽  
Niels T. Andersen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Diabetic Polyneuropathy ◽  
Corneal Confocal Microscopy

scholarly journals OBSERVATIONAL STUDY REGARDING RISK FACTORS AND COMORBITITES FOR CHRONIC KIDNEY DISEASE IN DIABETES MELLITUS PATIENTS FROM BIHOR COUNTY

2021 ◽  
Vol 68 (2) ◽  
pp. 188-193
Author(s):  
Adriana Baidog ◽  
◽  
Cosmin Vesa ◽  
Ioana Ratiu ◽  
Monica Sabau ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Kidney Disease ◽  
Observational Study ◽  
Past History ◽  
Diabetic Polyneuropathy

Introduction. Chronic kidney disease is a common comorbidity in diabetes mellitus type 2 patients because of presence of numerous risk factors such as obesity, hypertension, hyperglycemia and dyslipidemia. Material and methods. Our retrospective, observational study included 300 patients with type 2 diabetes mellitus from Bihor County and had the purpose to establish a clinical profile and to determine the risk factors associated with this pathology. Results. The prevalence of CKD was 75.67%. Older age, worse glucose control, presence of diabetic polyneuropathy and diabetic retinopathy, higher weight, past history of cardiovascular events, the presence of metabolic syndrome and hyperuricemia were associated with the presence of CKD. Conclusion. The clinical characteristics of type 2 diabetes mellitus patients with CKD is significantly worse compared with the population without CKD.

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