Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model

2010 ◽  
Vol 38 (6) ◽  
pp. 423-430 ◽  
Author(s):  
J.C. Roldán ◽  
R. Detsch ◽  
S. Schaefer ◽  
E. Chang ◽  
M. Kelantan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Calcium Phosphate ◽  
Mouse Model ◽  
Bone Formation ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramic ◽  
Highly Porous ◽  
Porous Biphasic Calcium Phosphate

Interaction between microspheres of collagen/biphasic calcium phosphate and mesenchymal stem cells

2012 ◽  
Vol 7 (12) ◽  
pp. 1217-1219
Author(s):  
Wei Zhang ◽  
Peng Wei ◽  
Yun Zeng ◽  
Jian Lu ◽  
Gang Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

scholarly journals Stimulation of bone formation by monocyte-activator functionalized graphene oxide in vivo

Nanoscale ◽  
2019 ◽  
Vol 11 (41) ◽  
pp. 19408-19421 ◽  
Author(s):  
Valentina Bordoni ◽  
Giacomo Reina ◽  
Marco Orecchioni ◽  
Giulia Furesi ◽  
Stefanie Thiele ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Graphene Oxide ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Calcium Phosphate Nanoparticles ◽  
Stimulation Of

Graphene oxide complexed with calcium phosphate nanoparticles enhances bone regeneration through signalling between monocytes and mesenchymal stem cells.

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