Fabrication and preliminary biological evaluation of a highly porous biphasic calcium phosphate scaffold with nano-hydroxyapatite surface coating

2018 ◽  
Vol 44 (2) ◽  
pp. 1304-1311 ◽  
Author(s):  
Jing Wang ◽  
Yu Zhu ◽  
Menglu Wang ◽  
Dan Liu ◽  
Xuening Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Surface Coating ◽  
Biphasic Calcium Phosphate ◽  
Biological Evaluation ◽  
Highly Porous ◽  
Porous Biphasic Calcium Phosphate

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

Fabrication of Porous Structure of BCP Sintered Bodies Using Microwave Assisted Synthesized HAp Nano Powder

2007 ◽  
Vol 534-536 ◽  
pp. 49-52 ◽  
Author(s):  
Min Ho Youn ◽  
Rajat Kanti Paul ◽  
Ho Yeon Song ◽  
Byong Taek Lee
Keyword(s):  
Calcium Phosphate ◽  
Porous Structure ◽  
Relative Density ◽  
Polymethyl Methacrylate ◽  
Biphasic Calcium Phosphate ◽  
Sintering Temperature ◽  
Microwave Assisted ◽  
Nano Powder ◽  
Maximum Value ◽  
Porous Biphasic Calcium Phosphate

Using microwave synthesized HAp nano powder and polymethyl methacrylate (PMMA) as a pore-forming agent, the porous biphasic calcium phosphate (BCP) ceramics were fabricated depending on the sintering temperature. The synthesized HAp powders was about 70-90 nm in diameter. In the porous sintered bodies, the pores having 150-180 μm were homogeneously dispersed in the BCP matrix. Some amounts of pores interconnected due the necking of PMMA powders which will increase the osteoconductivity and ingrowth of bone-tissues while using as a bone substrate. As the sintering temperature increased, the relative density increased and showed the maximum value of 79.6%. From the SBF experiment, the maximum resorption of Ca2+ ion was observed in the sample sintered at 1000°C.

RETRACTED: Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics

2012 ◽  
Vol 8 (10) ◽  
pp. 3794-3804 ◽  
Author(s):  
Bo Li ◽  
Xiaoling Liao ◽  
Li Zheng ◽  
Xiangdong Zhu ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Porous Biphasic Calcium Phosphate

Randomized clinical trial for the biological evaluation of two nanostructured biphasic calcium phosphate biomaterials as a bone substitute

2017 ◽  
Vol 19 (5) ◽  
pp. 802-811 ◽  
Author(s):  
Marcelo José Uzeda ◽  
Rodrigo Figueiredo de Brito Resende ◽  
Suelen Cristina Sartoretto ◽  
Adriana Terezinha Neves Novellino Alves ◽  
José Mauro Granjeiro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Calcium Phosphate ◽  
Randomized Clinical Trial ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Biological Evaluation

Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics

2005 ◽  
Vol 33 (9) ◽  
pp. 1238-1248 ◽  
Author(s):  
Heidi L. Holtorf ◽  
Tiffany L. Sheffield ◽  
Catherine G. Ambrose ◽  
John A. Jansen ◽  
Antonios G. Mikos
Keyword(s):  
Calcium Phosphate ◽  
Stromal Cells ◽  
Biphasic Calcium Phosphate ◽  
Perfusion Culture ◽  
Marrow Stromal Cells ◽  
Calcium Phosphate Ceramics ◽  
Flow Perfusion ◽  
Porous Biphasic Calcium Phosphate
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