All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells

2011 ◽  
Vol 149 (3) ◽  
pp. 281-291 ◽  
Author(s):  
Ruo-Jing Li ◽  
Xue Ying ◽  
Yan Zhang ◽  
Rui-Jun Ju ◽  
Xiao-Xing Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Stealth Liposomes ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Damian Emilio Berardi ◽  
Lizeth Ariza Bareño ◽  
Natalia Amigo ◽  
Luciana Cañonero ◽  
Maria de las Nieves Pelagatti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Protein Kinase C ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Combined Treatment ◽  
Self Renewal ◽  
Kinase C ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

AbstractBreast cancer is the leading cause of cancer death among women worldwide. Blocking a single signaling pathway is often an ineffective therapy, especially in the case of aggressive or drug-resistant tumors. Since we have previously described the mechanism involved in the crosstalk between Retinoic Acid system and protein kinase C (PKC) pathway, the rationale of our study was to evaluate the effect of combining all-trans-retinoic acid (ATRA) with a classical PCK inhibitor (Gö6976) in preclinical settings. Employing hormone-independent mammary cancer models, Gö6976 and ATRA combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile. Combined treatment also impairs growth, self-renewal and clonogenicity potential of cancer stem cells and reduced tumor growth, metastatic spread and cancer stem cells frequency in vivo. An in-silico analysis of “Kaplan–Meier plotter” database indicated that low PKCα together with high RARα mRNA expression is a favorable prognosis factor for hormone-independent breast cancer patients. Here we demonstrate that a classical PKC inhibitor potentiates ATRA antitumor effects also targeting cancer stem cells growth, self-renewal and frequency.

Low-dose all-trans retinoic acid enhances cytotoxicity of cisplatin and 5-fluorouracil on CD44+ cancer stem cells

2015 ◽  
Vol 74 ◽  
pp. 243-251 ◽  
Author(s):  
Nowruz Najafzadeh ◽  
Mohammad Mazani ◽  
Asadollah Abbasi ◽  
Faris Farassati ◽  
Mojtaba Amani
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Low Dose ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Targeting cancer stem cells in glioblastoma multiforme using mTOR inhibitors and the differentiating agent all-trans retinoic acid

2013 ◽  
Vol 30 (4) ◽  
pp. 1645-1650 ◽  
Author(s):  
MARISSA D. FRIEDMAN ◽  
DHRUVE S. JEEVAN ◽  
MICHAEL TOBIAS ◽  
RAJ MURALI ◽  
MEENA JHANWAR-UNIYAL
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Glioblastoma Multiforme ◽  
Cancer Stem Cells ◽  
Mtor Inhibitors ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Differentiating Agent

scholarly journals All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182835 ◽  
Author(s):  
Dan Mei ◽  
Bin Lv ◽  
Bo Chen ◽  
Shan Xiao ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Thyroid Cancer ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals All trans retinoic acid inhibits the gene expression of self-renewal and Notch signaling pathway in gastric cancer cells

2018 ◽  
Vol 34 (4) ◽  
Author(s):  
PHU HUNG NGUYEN ◽  
Thu Ha Ngo ◽  
Thi Binh Luu
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Retinoic Acid ◽  
Cancer Stem Cells ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
Self Renewal ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

All trans retinoic acid (ATRA) plays an important role in many cellular processes and is a potent promising substance for cancer therapy. The self-renewal is a prominent feature of cancer stem cells that is tightly controlled by a number of specific genes, and is also mediated by the cell signaling pathways. The Notch signal pathway has been shown to be one of the few major molecular signaling pathways of cancer stem cells, which regulates self-renewal and survival of cancer stem cells. In this study, we showed that ATRA reduced the expression of important genes involved in self-renewal of cells including Sox2, KLF4, DMNT1 and MYC as well as TBGUT markers such as CD24, MUC1 and CD90. Furthermore, we indicate that the ATRA-induced expression of self-renewal genes and cancer stem cell markers of gastric cancer stem cells can be mediated by the regulation of the Notch signaling pathway.

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