Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

2014 ◽  
Vol 177 ◽  
pp. 1-10 ◽  
Author(s):  
Sifei Han ◽  
Tim Quach ◽  
Luojuan Hu ◽  
Anisa Wahab ◽  
William N. Charman ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Lymphatic System ◽  
Alkyl Ester ◽  
Ester Versus

scholarly journals Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hea-Young Cho ◽  
Chong Ki Lee ◽  
Yong-Bok Lee
Keyword(s):  
Lymph Nodes ◽  
Targeted Delivery ◽  
Lymphatic System ◽  
Lipid Film ◽  
Pegylated Liposome ◽  
Pegylated Liposomes ◽  
Targeting Efficiency ◽  
Lymphatic Delivery ◽  
Preparation And Evaluation ◽  
Specific Ligand

This study attempted to prepare polyethylene-glycol modified (PEGylated) and folate-PEGylated liposomes containing paclitaxel (Ptx) in order to reduce the toxicity and improve the bioavailability and biocompatibility by targeting drugs to the lymphatics using cancer cell specific ligand folate to prevent metastasis via the lymphatic system. Liposomes were prepared by lipid film hydration method using PEG and folate-PEG as surface modifiers. The mean particle size and encapsulation efficiency of liposomes were114±6.81 nm and81±2.3% for PEGylated liposome and122±4.87 nm and88±2.0% for folate-PEGylated liposome, respectively. According to stability test, it could be confirmed that PEGylated and folate-PEGylated liposomes were stable for at least 5 days. After intravenous administration of the PEGylated and folate-PEGylated liposomes to rats, theCLt(total clearance) andt1/2(half-life) were significantly different (P<0.05) compared with those of PADEXOL Inj. In targeting efficiency, calculated as the concentration ratio of Ptx in lymph nodes and plasma, there was significant increase in targeting efficiency at lymph nodes (P<0.05). From these results, we could conclude that the prepared Ptx-containing PEGylated and folate-PEGylated liposomes are good candidates for the targeted delivery of the drug to lymphatic system.

scholarly journals THE EFFECT OF UNFRACTIONATED HEPARIN ON LYMPHATIC DRAINAGE OF TISSUES AND PHARMACOKINETICS OF CEFOTAXIM

2019 ◽  
Vol 25 (3) ◽  
pp. 181-184
Author(s):  
German V. Kukushkin ◽  
M. V Zhuravleva ◽  
L. P Sviridkina ◽  
D. E Yurov
Keyword(s):  
Blood Plasma ◽  
Unfractionated Heparin ◽  
Targeted Delivery ◽  
Liver Tissue ◽  
Lymphatic System ◽  
Lymphatic Drainage ◽  
Mouse Blood ◽  
Lymphatic Flow ◽  
Heparin Sodium ◽  
Lactam Antibiotic

Over the past decades, methods of targeted delivery of drugs to target tissues through the lymphatic system have been intensively developed, which makes it possible to create and maintain adequate concentrations of drugs. It has special meaning and impotence during the therapy antibiotic therapy of infectious and inflammatory processes. In this regard, the experimental study of pharmacological properties of drugs that enhance lymphatic drainage of tissues and at the same time promote the transport of antibiotics into the lymphatic system has natural interest. We studied the effect of unfractionated heparin sodium on lymphatic flow rate in tissues, the level of the β-lactam antibiotic cefotaxime in rabbit and mouse blood plasma and its concentration in mouse liver and intestinal tissues in experiments. Heparin sodium proved to be effective in stimulating lymphatic flow and facilitating endolymphatic delivery of the antibiotic. The administration of cefotaxime after an injection of heparin sodium led to the increased concentration of the antibiotic in rabbit blood plasma at all time points of the study (in an hour and a half and in 3 hours, in four and a half hours and in 6 hours, in 8, 12 and 24 hours), as well as the increased antibiotic level in mouse blood plasma and intestinal tissue in an hour and a half and in 24 hours after the injection. The cefotaxime level in liver tissue did not change, while its concentration ratio between liver tissue and blood plasma was falling, which suggests that the hepatic extraction of cefotaxime decreased. Considering the obtained evidence, we can recommend the clinical use of heparin sodium in lymphotropic therapy to facilitate endolymphatic delivery.

Scanning electron microscopy of freeze-fractured prescapular lymph node of caprine

1984 ◽  
Vol 42 ◽  
pp. 244-245
Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic System ◽  
Three Dimensional ◽  
Meat Products ◽  
The Body ◽  
Morphological Data ◽  
The World ◽  
Cellular Constituent ◽  
Scanning Electron

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.

Diagnostic Imaging and Interventional Therapies for the Lymphatic System: A Pictorial Essay

2019 ◽  
Author(s):  
Mohammad Toliyat ◽  
Anish Patel ◽  
Ali Alian ◽  
Patrick Sutphin ◽  
Sanjeeva Kalva
Keyword(s):  
Diagnostic Imaging ◽  
Lymphatic System ◽  
System A ◽  
Pictorial Essay ◽  
Interventional Therapies

Surgical treatment of alveolar echinococcosis: a single centre experience and systematic review of the literature

2019 ◽  
Vol 98 (4) ◽  
pp. 167-173
Keyword(s):  
Case Report ◽  
Echinococcus Multilocularis ◽  
Alveolar Echinococcosis ◽  
Lymphatic System ◽  
Surgical Intervention ◽  
Clinical Symptoms ◽  
Safety Margin ◽  
Surgical Removal ◽  
Single Centre Experience ◽  
Therapeutic Procedures

Introduction: Alveolar echinococcosis (AE) is a zoonosis caused by Echinococcus multilocularis. AE is primarily localised in the liver. Echinococcus multilocularis imitates tumour-like behaviour. It can metastasise through blood or lymphatic system to distant organs. Echinococcosis often remains asymptomatic due to its long incubation period and indistinct symptoms. Clinical symptoms are determined by the parasite’s location. Diagnosis of echinococcosis is based on medical history, clinical symptoms, laboratory tests, serology results, imaging methods and final histology findings. Surgical removal of the cyst with a safety margin, followed by chemotherapy is the therapeutic method of choice. Case report: We present a case report of alveolar echinococcosis in a thirty-year-old female patient in whom we surgically removed multiple liver foci of alveolar echinococcosis. The disease recurred after two years and required another surgical intervention. Conclusions: Alveolar echinococcosis is a disease with a high potential for a complete cure provided that it is diagnosed early and that the recommended therapeutic procedures are strictly adhered to.

EFFECT OF DIFFERENT DOSES OF PREDNISOLONE AND ADRENOCORTICOTROPHIC HORMONE (ACTH) ON LYMPHATIC LUNG CLEARANCE AND ON EXPERIMENTAL SILICOSIS

1970 ◽  
Vol 63 (2) ◽  
pp. 325-337
Author(s):  
Carl-Johan Göthe
Keyword(s):  
Lymph Nodes ◽  
Lymphatic System ◽  
The Body ◽  
Lung Weight ◽  
Lung Clearance ◽  
Dust Transport ◽  
Fine Particulate ◽  
Quartz Dust ◽  
Different Doses ◽  
Stimulation Of

ABSTRACT The effect of three doses of prednisolone and ACTH respectively on the weight of the body, the lungs and the hilar lymph nodes was studied on rats killed one month after the intratracheal (i.t.) injection of 50 mg of fine-particulate quartz. The prednisolone was administered via the drinking water, and the ACTH was injected intraperitoneally during the period between the i.t. injection of quartz dust and the killing of the animals. Prednisolone causes the rats to become cachectic and reduces the weight of the hilar lymph nodes. It also retards the transport of quartz dust from the lungs via the lymphatics. All these effects increase with increasing doses of prednisolone. However, its effect on the lung weight is insignificant. ACTH does not affect the body weight, but retards the weight increase of the lungs and the hilar lymph nodes. These effects increase with increasing doses of ACTH, and seem to be connected with an ability of ACTH to promote the clearance of quartz dust from the lungs and hilar lymph nodes. The method used, however, does not make it possible to differentiate quantitatively between any ACTH effects on the bronchogenie and lymphatic lung-clearance mechanisms. Available data, however, indicate that the stimulation of the dust transport from the lungs and hilar lymph nodes is, at least to some extent, related to the lymphatic system.

Infrared fluorescence lymphography in experimental and clinical practice

2018 ◽  
Vol 17 (2) ◽  
pp. 84-91 ◽  
Author(s):  
G. V. Papayan ◽  
A. L. Akopov ◽  
P. A. Antonyan ◽  
A. A. Ilin ◽  
N. N. Petrishchev
Keyword(s):  
Lymph Nodes ◽  
Near Infrared ◽  
Lymphatic System ◽  
Lymphatic Vessels ◽  
Diagnostic System ◽  
Biological Tissues ◽  
Peritumoral Injection ◽  
Intradermal Administration ◽  
Nir Fluorescence ◽  
Real Time Visualization

Introduction. Near infrared (NIR) fluorescent diagnostics is promising due to a deeper penetration into biological tissues. Material and methods. In experiments on rabbits and in clinical studies evaluation the lymphatic system with the use of the instrument complex FLUM-808 was analysed. Results. For visualization of the lymphatic vessels of the skin, the intradermal administration of ICG, dissolved in 20 % albumin in the order of 0.02 mg/ml, is optimal. Peritumoral injection of ICG allows visualizing sentinel lymph nodes in patients with lung cancer. Conclusions. The developed NIR fluorescence diagnostic system FLUM-808 allows to real time visualization of lymphatic vessels and lymph nodes.

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

Sign in / Sign up

Export Citation Format

Share Document