Biomimetic polymers responsive to a biological signaling molecule: Nitric oxide (NO) triggered reversible self-assembly of single macromolecular chains into nanoparticles

2015 ◽  
Vol 213 ◽  
pp. e55-e56 ◽  
Author(s):  
Jinming Hu ◽  
Michael R. Whittaker ◽  
Hien Duong ◽  
Yang Li ◽  
Cyrille Boyer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Biomimetic Polymers

Biomimetic Polymers Responsive to a Biological Signaling Molecule: Nitric Oxide Triggered Reversible Self-assembly of Single Macromolecular Chains into Nanoparticles

2014 ◽  
Vol 126 (30) ◽  
pp. 7913-7918 ◽  
Author(s):  
Jinming Hu ◽  
Michael R. Whittaker ◽  
Hien Duong ◽  
Yang Li ◽  
Cyrille Boyer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Biomimetic Polymers

Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies

2021 ◽  
Vol 28 ◽  
Author(s):  
Adeleh Sahebnasagh ◽  
Fatemeh Saghafi ◽  
Sina Negintaji ◽  
Tingyan Hu ◽  
Mojtaba Shabani-Boroujeni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Responses ◽  
Therapeutic Potential ◽  
Relevant Literature ◽  
Cochrane Library ◽  
Signaling Molecule ◽  
No Donors ◽  
The Cochrane Library ◽  
Oxide Synthase

: In recent years, there has been an increasing interest in understanding the mysterious functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to tumorigenesis. This review attempts to expose and discuss the information available on the immunomodulatory role of NO in cancer and recent approaches to the role of NO donors in the area of immunotherapy. To address the goal, the following databases were searched to identify relevant literature concerning empirical evidence: The Cochrane Library, Pubmed, Medline, EMBASE from 1980 through March 2020. Valuable attempts have been made to develop distinctive NO-based cancer therapy. Although the data do not allow generalization, the evidence seems to indicate that low / moderate levels may favor tumorigenesis while higher levels would exert anti-tumor effects. In this sense, the use of NO donors could have an important therapeutic potential within immunotherapy, although there are still no clinical trials. The emerging understanding of NO-regulated immune responses in cancer may help unravel the recent features of this “double-edged sword” in cancer physiological and pathologic processes and its potential use as a therapeutic agent for cancer treatment. In short, in this review, we discuss the complex cellular mechanism in which NO, as a pleiotropic signaling molecule, participates in cancer pathophysiology. We also debate the dual role of NO in cancer and tumor progression, and clinical approaches for inducible nitric oxide synthase (iNOS) based therapy against cancer.

Nitric oxide-releasing platinum(iv) prodrug efficiently inhibits proliferation and metastasis of cancer cells

2020 ◽  
Vol 56 (90) ◽  
pp. 14051-14054
Author(s):  
Yi Dai ◽  
Yang Zhu ◽  
Junjie Cheng ◽  
Juan Shen ◽  
Hai Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Tumor Metastasis ◽  
Dual Function ◽  
Signaling Molecule ◽  
Proliferation And Metastasis ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Inhibit Tumor Metastasis

Pt–furoxan, a nitric oxide-releasing platinum(iv) prodrug, exhibits a dual function by releasing cytotoxic cisplatin to induce cell apoptosis, and signaling molecule NO to inhibit tumor metastasis.

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology

1999 ◽  
Vol 19 (2) ◽  
pp. 51-71 ◽  
Author(s):  
Louis J. Ignarro
Keyword(s):  
Nitric Oxide ◽  
Cell Signaling ◽  
Vascular Biology ◽  
Signaling Molecule

The properties of nitric oxide as an endogenous cell signaling molecule in vascular biology are described.

scholarly journals Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

2016 ◽  
Vol 113 (27) ◽  
pp. 7539-7544 ◽  
Author(s):  
David A. Hanna ◽  
Raven M. Harvey ◽  
Osiris Martinez-Guzman ◽  
Xiaojing Yuan ◽  
Bindu Chandrasekharan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glycolytic Enzyme ◽  
Unicellular Eukaryote ◽  
Human Cell Lines ◽  
State Distribution ◽  
Signaling Molecule ◽  
Nuclear Transcription Factor ◽  
Heme Acquisition ◽  
Oxidation State Distribution ◽  
Heme Trafficking

Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and heme signaling are ultimately reliant on the ability to mobilize labile heme (LH). However, the properties of LH pools, including concentration, oxidation state, distribution, speciation, and dynamics, are poorly understood. Herein, we elucidate the nature and dynamics of LH using genetically encoded ratiometric fluorescent heme sensors in the unicellular eukaryoteSaccharomyces cerevisiae. We find that the subcellular distribution of LH is heterogeneous; the cytosol maintains LH at ∼20–40 nM, whereas the mitochondria and nucleus maintain it at concentrations below 2.5 nM. Further, we find that the signaling molecule nitric oxide can initiate the rapid mobilization of heme in the cytosol and nucleus from certain thiol-containing factors. We also find that the glycolytic enzyme glyceraldehyde phosphate dehydrogenase constitutes a major cellular heme buffer, and is responsible for maintaining the activity of the heme-dependent nuclear transcription factor heme activator protein (Hap1p). Altogether, we demonstrate that the heme sensors can be used to reveal fundamental aspects of heme trafficking and dynamics and can be used across multiple organisms, includingEscherichia coli, yeast, and human cell lines.

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