scholarly journals Impact of octreotide counterion nature on the long-term stability and release kinetics from an in situ forming depot technology

2021 ◽  
Vol 336 ◽  
pp. 457-468
Author(s):  
Charlotte Molinier ◽  
Marina Picot-Groz ◽  
Océane Malval ◽  
Sophie Le Lamer-Déchamps ◽  
Joël Richard ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Term Stability ◽  
Long Term Stability ◽  
In Situ Forming ◽  
Counterion Nature

scholarly journals Middle Ear Transducer: Long Term Stability of the Latest Generation T2

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Nils Kristian Prenzler ◽  
Eugen Kludt ◽  
Thomas Giere ◽  
Rolf Salcher ◽  
Thomas Lenarz ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Observation Time ◽  
Term Stability ◽  
Long Term Stability ◽  
Average Observation ◽  
Technical Failures

Objectives/Hypothesis. Comparing long term stability of the Middle Ear Transducers (MET) of the 1st generation T1 (Otologics LLC) with the current generation T2 (Cochlear Ltd.) in all our clinical cases with standard incus coupling. Study Design. Retrospective chart review. Methods. 52 ears implanted with a MET device between 2008 and 2016 were analyzed retrospectively. All patients suffered from sensorineural hearing loss and the actuator was coupled to the body of the incus (standard coupling). 23 ears were implanted with the transducer T1 (Otologics LLC) between 2008 and 2011 and 29 ears were implanted with the current transducer T2 since 2011 (Otologics LLC/Cochlear Ltd.). Latest available in situ and bone conduction (BC) thresholds were exploited for a follow-up period of up to 7 years after first fitting. Long term stability of coupling and actuator performance was evaluated by tracking differences between in situ and BC thresholds. Results. In the T1 group, 9 out of 23 implants were still used by the patients at their last follow-up visit (average observation time 3.7 yrs.; min 1.0 yrs., max 7.4 yrs.). In 9 patients a technical failure identified by a decrease of in situ threshold of more than 15 dB compared to BC thresholds [Δ (in situ – BC)] lead to non-usage of the implant and 7 explantations. Five other explantations occurred due to medical reasons such as BC threshold decrease, infection, or insufficient speech intelligibility with the device. In the T2 group, 23 out of 29 implants were still used at the most current follow-up visit (average observation time 3.3 yrs.; min 1.0 yrs., max 4.8 yrs.). No technical failures were observed up to more than 4 years after implantation. Five T2 patients discontinued using the device due to insufficient benefit; two of these patients were explanted. One patient had to be explanted before the activation of the device due to disorders of wound healing. Nevertheless, a small but significant decrease of hearing loss corrected coupling efficiency [Δ (in situ – BC)] was seen in the T2 group. Conclusions. In contrast to the T1 transducers of the earlier generation of MET systems where technical failures occurred frequently, no technical failures were detected after 29 implantations with the current T2 transducers. However, a small but significant decline of transmission efficiency was observable even in the T2 implanted group.

Reduction of bioaccessibility of As in soil through in situ formation of amorphous Fe oxides and its long-term stability

2020 ◽  
Vol 745 ◽  
pp. 140989
Author(s):  
Jinhee Park ◽  
Jinsung An ◽  
Hyeonyong Chung ◽  
Sang Hyun Kim ◽  
Kyoungphile Nam
Keyword(s):  
Term Stability ◽  
Long Term Stability ◽  
Fe Oxides ◽  
In Situ Formation

Fabrication toward Stable Perovskite Solar Cells with Efficiency over 20% under Open Air via In-situ Polymerized Bi-functional Additive

2022 ◽  
Author(s):  
Lei Ning ◽  
Providence Buregeya Ingabire ◽  
Ningxia Gu ◽  
Ping-Fan Du ◽  
Dongfang Lv ◽  
...  
Keyword(s):  
Solar Cells ◽  
Grain Boundaries ◽  
Photovoltaic Performance ◽  
Perovskite Solar Cells ◽  
Term Stability ◽  
Long Term Stability ◽  
Functional Additive

Essentially, detrimental defects distributed at perovskite surface and grain boundaries (GBs) directly impede the further enhancement of both the photovoltaic performance and long-term stability of perovskite solar cells (PSCs). Herein,...

In Situ Electrodeposited FePt Nanoparticles for Oxygen Reduction with High Activity and Long-term Stability

2010 ◽  
Vol 39 (10) ◽  
pp. 1114-1116 ◽  
Author(s):  
Di Liu ◽  
Yang Tian ◽  
Anwei Zhu ◽  
Yongping Luo
Keyword(s):  
Oxygen Reduction ◽  
High Activity ◽  
Fept Nanoparticles ◽  
Term Stability ◽  
Long Term Stability

Fe3C nanoparticles encapsulated in highly crystalline porous graphite: salt-template synthesis and enhanced electrocatalytic oxygen evolution activity and stability

2018 ◽  
Vol 54 (25) ◽  
pp. 3158-3161 ◽  
Author(s):  
Yang Zhang ◽  
Jiantao Zai ◽  
Kai He ◽  
Xuefeng Qian
Keyword(s):  
Oxygen Evolution ◽  
Template Synthesis ◽  
Template Method ◽  
Term Stability ◽  
Long Term Stability ◽  
Porous Graphite ◽  
Fe3c Nanoparticles

Fe3C nanoparticles encapsulated in highly crystalline porous graphite were prepared via an in situ salt template method and showed enhanced electrocatalytic OER activity and long-term stability.

A bimetallic MOF@graphene oxide composite as an efficient bifunctional oxygen electrocatalyst for rechargeable Zn–air batteries

2020 ◽  
Vol 49 (17) ◽  
pp. 5730-5735 ◽  
Author(s):  
Yao Xiao ◽  
Beibei Guo ◽  
Jing Zhang ◽  
Chun Hu ◽  
Ruguang Ma ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Growth Strategy ◽  
Air Cathode ◽  
Discharge Performance ◽  
Oxide Composite ◽  
Term Stability ◽  
Long Term Stability ◽  
Charge Discharge

A bimetallic ZnCo-ZIF@graphene oxide (ZnCo-ZIF@GO) composite was synthesized via an in situ growth strategy. As the air cathode of Zn–air batteries, ZnCo-ZIF@GO showed good charge/discharge performance and long-term stability.

In situ formation of CsPbBr3/ZnO bulk heterojunctions towards photodetectors with ultrahigh responsivity

2018 ◽  
Vol 6 (45) ◽  
pp. 12164-12169 ◽  
Author(s):  
Yalong Shen ◽  
Chao Wei ◽  
Lianbo Ma ◽  
Shalong Wang ◽  
Xiong Wang ◽  
...  
Keyword(s):  
Bulk Heterojunctions ◽  
Solution Processed ◽  
Imaging Capability ◽  
Term Stability ◽  
Long Term Stability ◽  
In Situ Formation

A solution-processed hybrid photodetector based on in situ formed CsPbBr3/ZnO bulk heterojunctions exhibited ultrahigh responsivity, long-term stability and desirable imaging capability.

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