scholarly journals Prediction of cardiac surgery associated - acute kidney injury (CSA-AKI) by healthcare professionals and urine cell cycle arrest AKI biomarkers [TIMP-2]*[IGFBP7]: A single center prospective study (the PREDICTAKI trial)

2022 ◽  
Vol 67 ◽  
pp. 108-117
Author(s):  
Wim Vandenberghe ◽  
Lien Van Laethem ◽  
Ingrid Herck ◽  
Harlinde Peperstraete ◽  
Hannah Schaubroeck ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Prospective Study ◽  
Cell Cycle Arrest ◽  
Healthcare Professionals ◽  
Kidney Injury ◽  
Single Center ◽  
Cycle Arrest

scholarly journals Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury after Pediatric Cardiac Surgery

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110865 ◽  
Author(s):  
Melanie Meersch ◽  
Christoph Schmidt ◽  
Hugo Van Aken ◽  
Jan Rossaint ◽  
Dennis Görlich ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Pediatric Cardiac Surgery ◽  
Cycle Arrest

scholarly journals Intraoperative prediction of cardiac surgery–associated acute kidney injury using urinary biomarkers of cell cycle arrest

2019 ◽  
Vol 157 (4) ◽  
pp. 1545-1553.e5 ◽  
Author(s):  
Jared J. Cummings ◽  
Andrew D. Shaw ◽  
Jing Shi ◽  
Marcos G. Lopez ◽  
Jason B. O'Neal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Urinary Biomarkers ◽  
Cycle Arrest

Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery

2017 ◽  
Vol 32 (9) ◽  
pp. 1611-1619 ◽  
Author(s):  
Katja M. Gist ◽  
Stuart L. Goldstein ◽  
Julia Wrona ◽  
Jeffrey A. Alten ◽  
Rajit K. Basu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Cycle Arrest ◽  
Kinetics Of

scholarly journals Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Critical Care ◽  
2013 ◽  
Vol 17 (1) ◽  
pp. R25 ◽  
Author(s):  
Kianoush Kashani ◽  
Ali Al-Khafaji ◽  
Thomas Ardiles ◽  
Antonio Artigas ◽  
Sean M Bagshaw ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Cycle Arrest

Improving clinical prediction rules in acute kidney injury with the use of biomarkers of cell cycle arrest: a pilot study

Biomarkers ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Luke E. Hodgson ◽  
Richard M. Venn ◽  
Steve Short ◽  
Paul J. Roderick ◽  
Duncan Hargreaves ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Pilot Study ◽  
Cell Cycle Arrest ◽  
Kidney Injury ◽  
Clinical Prediction ◽  
Clinical Prediction Rules ◽  
Prediction Rules ◽  
Cycle Arrest

scholarly journals Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides

2020 ◽  
Vol 14 (10) ◽  
pp. 879-894
Author(s):  
Hayton Chui ◽  
Jillian Caldwell ◽  
Mariya Yordanova ◽  
Vedran Cockovski ◽  
Daniel Fredric ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Kidney Injury ◽  
Febrile Neutropenia ◽  
Prospective Study ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Tubular Injury ◽  
Early Biomarkers ◽  
Cycle Arrest ◽  
A Prospective Study

Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) for biomarkers to detect AKI was calculated by a) days before AKI onset; b) treatment days. Results: There were 113 AG episodes (68% febrile neutropenia). The AKI group had a higher proportion with febrile neutropenia. The AKI group had significantly lower NGAL 3 days before AKI, as patients with febrile neutropenia had a lower NGAL during AG treatment (p < 0.05). NGAL, IL-18 and TIMP2*IGFBP7 had AUC ≥0.73 at 3, 2 and 2 days before AKI onset. Conclusion: NGAL, IL-18 and TIMP2*IGFBP7 were modest early biomarkers of AG-AKI. Febrile neutropenia was associated with lower NGAL.

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