The medicinal mushroom agaricus blazei murill activates NF-κB via TLR2 in monocytic cells, induces expansion of CD56+ but not other HSC, and activation of human monocyte-derived DC in vitro

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. S36
Author(s):  
G. Hetland ◽  
J. Tangen ◽  
A.M. Tryggestad ◽  
M.S. Dyrhaug ◽  
G. Kvalheim
Keyword(s):  
Human Monocyte ◽  
Medicinal Mushroom ◽  
Agaricus Blazei ◽  
Monocytic Cells ◽  
Agaricus Blazei Murill

Bioaccessibility of cadmium in fresh and cooked Agaricus blazei Murill assessed by in vitro biomimetic digestion system

2012 ◽  
Vol 50 (5) ◽  
pp. 1729-1733 ◽  
Author(s):  
Liping Sun ◽  
Gaoxiang Liu ◽  
Meizhizi Yang ◽  
Yongliang Zhuang
Keyword(s):  
Agaricus Blazei ◽  
Agaricus Blazei Murill

Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro

2002 ◽  
Vol 40 (12) ◽  
pp. 1775-1780 ◽  
Author(s):  
J Martins de Oliveira ◽  
B.Q Jordão ◽  
L.R Ribeiro ◽  
A Ferreira da Eira ◽  
M.S Mantovani
Keyword(s):  
Mammalian Cells ◽  
Genotoxic Effect ◽  
Aqueous Extracts ◽  
Agaricus Blazei ◽  
Agaricus Blazei Murill

scholarly journals Chemical, enzymatic and cellular antioxidant activity studies of Agaricus blazei Murrill

2013 ◽  
Vol 85 (3) ◽  
pp. 1073-1082 ◽  
Author(s):  
RICARDO A. HAKIME-SILVA ◽  
JOSE C.R. VELLOSA ◽  
NAJEH M. KHALIL ◽  
OMAR A.K. KHALIL ◽  
IGUATEMY L. BRUNETTI ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Direct Action ◽  
Antioxidant Properties ◽  
Polymorphonuclear Neutrophils ◽  
Free Radical Scavengers ◽  
Agaricus Blazei ◽  
Resistance To Oxidation ◽  
Medicinal Properties ◽  
Agaricus Blazei Murill

Mushrooms possess nutritional and medicinal properties that have long been used for human health preservation and that have been considered by researchers as possible sources of free radical scavengers. In this work, the antioxidant properties of water extracts from Agaricus blazei Murill, produced by maceration and decoction, are demonstrated in vitro. Resistance to oxidation is demonstrated through three mechanisms: i) inhibition of enzymatic oxidative process, with 100% inhibition of HRP (horseradish peroxidase) and MPO (myeloperoxidase); ii) inhibition of cellular oxidative stress, with 80% inhibition of the oxidative burst of polymorphonuclear neutrophils (PMNs); and iii) direct action over reactive species, with 62% and 87% suppression of HOCl and superoxide anion radical (O2• –), respectively. From the data, it was concluded that the aqueous extract of A. blazei has significant antioxidant activity, indicating its possible application for nutraceutical and medicinal purposes.

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