Development of ibuprofen-loaded solid lipid nanoparticle-based hydrogels for enhanced in vitro dermal permeation and in vivo topical anti-inflammatory activity

2020 ◽  
Vol 57 ◽  
pp. 101758 ◽  
Author(s):  
Cuong Viet Pham ◽  
Mao Can Van ◽  
Hue Pham Thi ◽  
Chung Đang Thanh ◽  
Bao Tran Ngoc ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Anti Inflammatory

scholarly journals Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo

2019 ◽  
Vol Volume 14 ◽  
pp. 3283-3295 ◽  
Author(s):  
Wan-Li Liang ◽  
Lan Xiao ◽  
Hong-Wei Gu ◽  
Xiao-Jun Li ◽  
Yu-Sang Li ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Induced Apoptosis ◽  
Dependent Pathway

Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo

2016 ◽  
Vol 43 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Li-Hua Peng ◽  
Wei Wei ◽  
Ying-Hui Shan ◽  
Yee-Song Chong ◽  
Lian Yu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Anti Inflammatory

LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF CELECOXIB: AN IN VITRO AND IN VIVO INVESTIGATION

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (08) ◽  
pp. 38-48
Author(s):  
S. V Shinde ◽  
S Nikam ◽  
P Raut ◽  
M. K. Ghag ◽  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Research Work ◽  
Lipid Nanoparticles ◽  
Inflammatory Activity ◽  
Promising Alternative ◽  
Solid Lipid ◽  
Anti Inflammatory

In the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design was applied. The optimized batch was characterized physicochemically and evaluated through DSC, SEM and XRD studies. The mean particle size of the optimized batch was found to be 135.41± 0.24 nm with a mean % entrapment efficiency of 80 ± 1.69%. The optimized batch was further lyophilized and dispersed into 1% w/v Carbopol 934P to form a gel. Prepared gel was further evaluated for in vitro drug release, occlusivity, ex vivo permeability, local toxicity, in vivo anti-inflammatory activity and accelerated stability study. The study resulted in stable, safe and prolonged anti-inflammatory activity with quick onset of action. Hence, celecoxib loaded solid lipid nanoparticles can be considered as promising alternative to conventional topical systems.

Application of Novel Solid Lipid Nanoparticle (SLN)-Gene Vector Formulations Based on a Dimeric HIV-1 TAT-Peptide in Vitro and in Vivo

2004 ◽  
Vol 21 (9) ◽  
pp. 1662-1669 ◽  
Author(s):  
Carsten Rudolph ◽  
Ulrike Schillinger ◽  
Aurora Ortiz ◽  
Kerstin Tabatt ◽  
Christian Plank ◽  
...  
Keyword(s):  
Gene Vector ◽  
Tat Peptide ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Hiv 1

scholarly journals Solid Lipid Nanoparticle Formulations of Docetaxel Prepared with High Melting Point Triglycerides: In Vitro and in Vivo Evaluation

2014 ◽  
Vol 11 (4) ◽  
pp. 1239-1249 ◽  
Author(s):  
Youssef Wahib Naguib ◽  
B. Leticia Rodriguez ◽  
Xinran Li ◽  
Stephen D. Hursting ◽  
Robert O. Williams ◽  
...  
Keyword(s):  
Melting Point ◽  
High Melting ◽  
Solid Lipid Nanoparticle ◽  
High Melting Point ◽  
In Vivo Evaluation ◽  
Solid Lipid ◽  
Lipid Nanoparticle

scholarly journals Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3971 ◽  
Author(s):  
Mona Qushawy ◽  
Kousalya Prabahar ◽  
Mohammed Abd-Alhaseeb ◽  
Shady Swidan ◽  
Ali Nasr
Keyword(s):  
Histopathological Examination ◽  
In Vitro Release ◽  
Aqueous Dispersion ◽  
Entrapment Efficiency ◽  
Anticonvulsant Effect ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle

Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results: The prepared CBZ-SLN showed a high entrapment efficiency% (39.66 ± 2.42%–71.91 ± 1.21%), a small particle size (45.11 ± 6.72–760.7 ± 5.25 nm), and a negative zeta potential (from −21.5 ± 1.02 to −38.4 ± 1.32 mv). The in vitro release study showed the slow release of CBZ from SLNs compared to CBZ aqueous dispersion (p < 0.05). The infrared spectroscopy and the thermal analysis revealed the compatibility of the drug with other ingredients and the presence of drug in the more soluble amorphous estate, respectively. The in vivo study on mice revealed that the CBZ-SLN had a higher anticonvulsant efficacy than CBZ aqueous dispersion after a lethal and chronic dose of pentylenetetrazole (PTZ) (p < 0.05). The histopathological examination of the hippocampus revealed a decrease in the percentage of degeneration in mice treated with the CBZ-SLN compared to the PTZ and CBZ groups. Conclusion: CBZ can be formulated as SLN with higher anticonvulsant activity than free CBZ aqueous dispersion.

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