Change from oral antidiabetic therapy to insulin and risk of urinary tract infections in Type 2 diabetic patients: a population-based prescription study

Abstract Background Urinary tract infection is the most common infection in type 2 diabetic patients. Various studies have reported different outbreaks of urinary tract infections in type 2 diabetic patients, Therefore, the present study aimed to determine the prevalence of urinary tract infections in type 2 diabetic patients during a systematic review and meta-analysis to open windows to more detailed programs to reduce the incidence of urinary tract infections in type 2 diabetic patients. Methods In this study, systematic review and Meta-Analysis of study data related to the prevalence of urinary tract infection in type 2 diabetic patients using keywords including: Type 2 diabetes, urinary tract infection, diabetes, prevalence, Meta-Analysis and their English equivalents in SID, MagIran, IranMedex, IranDoc, Google scholar, Cochrane, Embase, Science Direct, Scopus, PubMed and Web of Science (ISI) databases over the years It was mined from 1993 to 2020.In order to perform the analysis of qualified studies, the model of random effects was used and the inconsistency of studies with I2 index was investigated. Data analysis was performed with Comprehensive Meta-Analysis (version 2). Results In a study of 15 studies with a sample size of 827,948 in Meta-Analysis, the overall prevalence of urinary tract infection in patients with type 2 diabetes was 11.5% (95% confidence interval: 7.8–16.7%). Increasing the number of years of research, the prevalence of urinary tract infections in diabetic patients of the Iranian type increased (P = 0.000), and with increasing age of participants (P = 0.000) and also with increasing sample size (P = 0.000), this prevalence decreased. Conclusion The results of this study show that urinary tract infections are highly prevalent in patients with type 2 diabetes, so due to the growing prevalence of diabetes and its complications such as urinary tract infections, the need for appropriate screening programs and health care policies is becoming more apparent.

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Change of initial oral antidiabetic therapy in type 2 diabetic patients

Pharmacy World & Science ◽

10.1007/s11096-009-9321-0 ◽

2009 ◽

Vol 31 (6) ◽

pp. 622-626 ◽

Cited By ~ 7

Author(s):

Arian Plat ◽

Fernie Penning-van Beest ◽

Sophia Kessabi ◽

Martijn Groot ◽

Ron Herings

Keyword(s):

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Antidiabetic Therapy ◽

Oral Antidiabetic ◽

Type 2 Diabetic

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Asymptomatic Urinary Tract Infections and Associated Risk Factors in Pakistani Muslim Type 2 Diabetic Patients

10.21203/rs.3.rs-161787/v1 ◽

2021 ◽

Author(s):

Azizul Hasan Aamir ◽

Umar Yousuf Raja ◽

Ali Asghar ◽

Saeed Ahmed Mahar ◽

Tahir Ghaffar ◽

...

Keyword(s):

Escherichia Coli ◽

Urinary Tract ◽

Urine Culture ◽

Diabetic Patients ◽

Positive Urine Culture ◽

Type 2 Diabetic Patients ◽

Positive Urine ◽

Tract Infections ◽

Type 2 Diabetic

Abstract Background: One of the leading long-term complications of type 2 diabetes mellitus (T2DM) includes renal dysfunction and urinary tract infections (UTI) which are considered to be prevalent in uncontrolled diabetes. Moreover, physiological factors like age, gender, duration of diabetes, other diabetic complications like neuropathy, autonomic neuropathy and glycosuria are also considered as predisposing factors for increased prevalence of UTI in diabetes which can be symptomatic or asymptomatic. Methods: This was a cross-sectional, multi-centre study including diabetic patients from 12 clinical sites spread across major cities of Pakistan. The inclusion criteria were adult Pakistani population of age between 18 to 75 years both genders and suffering from T2DM irrespective of duration. A detailed clinical history of the past 3 months was recorded and, biochemical investigations of blood samples were conducted. Urine culture analysis performed identified the type of pathogen present and was done only for asymptomatic patients. Results: A total of 745 type 2 diabetic patients were initially screened, out of 545 patients considered for final analysis 501 (91.92%) were negative and the rest 44 (8.08%) had positive urine culture. Female gender had a significantly higher proportion of positive urine culture (77.27%, p-value<0.001). Body mass index and mean age had insignificant distribution among the two groups of positive and negative urine culture, with age 40-59 years having higher proportion (70.45%) in the positive group. Escherichia coli was detected in most of the positive samples (52.3%). All bacterial samples were found resistant to Ciprofloxacin. Conclusion: Diabetic female patients are identified to be at high risk of suffering from UTI and age more than 40 years is an important risk factor. Escherichia coli was the most common causative organism among people living in this geographical area.

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Asymptomatic urinary tract infections and associated risk factors in Pakistani Muslim type 2 diabetic patients

BMC Infectious Diseases ◽

10.1186/s12879-021-06106-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Azizul Hasan Aamir ◽

Umar Yousuf Raja ◽

Ali Asghar ◽

Saeed Ahmed Mahar ◽

Tahir Ghaffar ◽

...

Keyword(s):

Escherichia Coli ◽

Urinary Tract ◽

Urine Culture ◽

Diabetic Patients ◽

Positive Urine Culture ◽

Type 2 Diabetic Patients ◽

Positive Urine ◽

Tract Infections ◽

Type 2 Diabetic

Abstract Background One of the leading long-term complications of type 2 diabetes mellitus (T2DM) includes renal dysfunction and urinary tract infections (UTI) which are considered to be prevalent in uncontrolled diabetes. Moreover, physiological factors like age, gender, duration of diabetes, other diabetic complications like neuropathy, autonomic neuropathy and glycosuria are also considered as predisposing factors for increased prevalence of UTI in diabetes which can be symptomatic or asymptomatic. Methods This was a cross-sectional, multi-centre study including diabetic patients from 12 clinical sites spread across major cities of Pakistan. The inclusion criteria were adult Pakistani population of age between 18 to 75 years both genders and suffering from T2DM irrespective of duration. A detailed clinical history of the past 3 months was recorded and, biochemical investigations of blood samples were conducted. Urine culture analysis performed identified the type of pathogen present and was done only for asymptomatic patients. Results A total of 745 type 2 diabetic patients were initially screened, out of 545 patients considered for final analysis 501 (91.92%) were negative and the rest 44 (8.08%) had positive urine culture. Female gender had a significantly higher proportion of positive urine culture (77.27%, p-value< 0.001). Body mass index and mean age had insignificant distribution among the two groups of positive and negative urine culture, with age 40–59 years having higher proportion (70.45%) in the positive group. Escherichia coli was detected in most of the positive samples (52.3%). All bacterial samples were found resistant to Ciprofloxacin. Conclusion Diabetic Pakistani muslim female patients are identified to be at high risk of suffering from asymptomatic UTI and age more than 40 years is an important risk factor. Escherichia coli was the most common causative organism among people living in this geographical area.

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