Relationship between plasma glycation with membrane modification, oxidative stress and expression of glucose trasporter-1 in type 2 diabetes patients with vascular complications

2017 ◽  
Vol 31 (2) ◽  
pp. 439-448 ◽  
Author(s):  
Krishna A. Adeshara ◽  
Arundhati G. Diwan ◽  
Tejashri R. Jagtap ◽  
Komal Advani ◽  
Aisha Siddiqui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Membrane Modification ◽  
Diabetes Patients

scholarly journals Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Samira Tajbakhsh ◽  
Kamelya Aliakbari ◽  
Damian J. Hussey ◽  
Karen M. Lower ◽  
Anthony J. Donato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Type 2 Diabetes ◽  
Vascular Dysfunction ◽  
Vascular Complications ◽  
Sirtuin 1 ◽  
Telomere Shortening ◽  
Telomere Attrition ◽  
Clinical Complications

Vascular dysfunction is an early feature of diabetic vascular disease, due to increased oxidative stress and reduced nitric oxide (NO) bioavailability. This can lead to endothelial cell senescence and clinical complications such as stroke. Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition. Sirtuin 1 (SIRT1) has been linked to vascular health by upregulating endothelial nitric oxide synthase (eNOS), suppressing oxidative stress, and attenuating telomere shortening. Accelerated leukocyte telomere attrition appears to be a feature of clinical type 2 diabetes (T2D) and therefore the telomere system may be a potential therapeutic target in preventing vascular complications of T2D. However the effect of T2D on vascular telomere length is currently unknown. We hypothesized that T2D gives rise to shortened leukocyte and vascular telomeres alongside reduced vascular SIRT1 expression and increased oxidative stress. Accelerated telomere attrition was observed in circulating leukocytes, but not arteries, in T2D compared to control rats. T2D rats had blunted arterial SIRT1 and eNOS protein expression levels which were associated with reduced antioxidant defense capacity. Our findings suggest that hyperglycemia and a deficit in vascular SIRT1per seare not sufficient to prematurely shorten vascular telomeres.

scholarly journals Beneficial effects through aggressive coronary screening for type 2 diabetes patients with advanced vascular complications

Medicine ◽  
2016 ◽  
Vol 95 (33) ◽  
pp. e4307 ◽  
Author(s):  
Tetsuro Tsujimoto ◽  
Takehiro Sugiyama ◽  
Ritsuko Yamamoto-Honda ◽  
Miyako Kishimoto ◽  
Hiroshi Noto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Beneficial Effects ◽  
Coronary Screening ◽  
Diabetes Patients

Association between oxidative-stress-related markers and calcified femoral artery in type 2 diabetes patients

2020 ◽  
Vol 190 ◽  
pp. 113535
Author(s):  
Francisco Andújar-Vera ◽  
Cristina García-Fontana ◽  
Silvia Lozano-Alonso ◽  
Sheila González-Salvatierra ◽  
Iván Iglesias-Baena ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Femoral Artery ◽  
Diabetes Patients

scholarly journals No Relevant Relationship between Glucose Variability and Oxidative Stress in Well-Regulated Type 2 Diabetes Patients

2011 ◽  
Vol 5 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Sarah E. Siegelaar ◽  
Temo Barwari ◽  
Wim Kulik ◽  
Joost B. Hoekstra ◽  
J. Hans DeVries
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Glucose Variability ◽  
And Oxidative Stress ◽  
Diabetes Patients
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