Interaction between the rs9356744 polymorphism and metabolic risk factors in relation to type 2 diabetes mellitus: The Cardiometabolic Risk in Chinese (CRC) Study

2021 ◽  
pp. 107855
Author(s):  
Fei Teng ◽  
Ruihao Qin ◽  
Xuekui Liu ◽  
Houfa Geng ◽  
Wei Xu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiometabolic Risk ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

scholarly journals Cardio-Metabolic Benefits of Walnuts in Type 2 Diabetes Mellitus: A Literature Review

2021 ◽  
pp. 111-124
Author(s):  
Valentine Y Njike ◽  
Genevieve Cecile Kela ◽  
Nisar Khan ◽  
Rockiy Ayettey ◽  
Maxime Tindong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
At Risk ◽  
Type 2 Diabetes Mellitus ◽  
Weight Gain ◽  
Glycaemic Control ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

Diabetes and its complications are main causes of morbidity and mortality among adults in the USA. An increase in the number of individuals with diabetes is primarily attributed to changes in dietary patterns including increased consumption of obesogenic foods and beverages. Many individuals who are overweight and obese show signs of insulin resistance and are at increased risk of Type 2 diabetes mellitus (T2DM) and cardiovascular disease. Lifestyle interventions (i.e., physical activity and nutrition) are the cornerstone of T2DM management and prevention. Prior research attests to the health benefits of consuming nuts, which have a substantial amount of mono- and polyunsaturated fatty acids, for individuals at risk for or with T2DM, and walnuts appear to be particularly promising. Walnuts are rich in nutrients, minerals, antioxidants, and vitamins that can contribute to improved cardio-metabolic risk factors in individuals at risk for or with T2DM. This review assesses the cardio-metabolic benefits of walnuts in T2DM. The authors’ review indicates that the reported effects of walnuts on glycaemic control have been inconclusive, with several studies showing association with improved glycaemic control while others show no effect. Despite their high energy density and potential to contribute to weight gain, the authors’ review suggests that walnuts can contribute to satiety without association with weight gain. This review also suggests that walnut consumption has been associated with improved low-density lipoprotein cholesterol levels and endothelial function but has not been associated with blood pressure improvement. Meta-analyses are warranted to quantitatively assess impact of walnut consumption on these cardio-metabolic risk factors in T2DM.

scholarly journals Dietary quality indices modify the effects of apolipoprotein B polymorphisms on cardio-metabolic risk factors in type 2 diabetes mellitus 

2021 ◽  
Author(s):  
Elmira Karimi ◽  
Gity Sotoudeh ◽  
Masoumeh Rafiee ◽  
Fariba Koohdani
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Apolipoprotein B ◽  
Metabolic Risk Factors ◽  
Dietary Quality ◽  
Metabolic Risk ◽  
Quality Indices

Abstract We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). This cross-sectional study recruited 700 adults with T2DM in Tehran. The genotypes of Ins/Del and EcoR1 single nucleotide polymorphisms (SNP) were explored via polymerase chain reaction (PCR). Dietary quality index-international (DQI-I), healthy eating index-2015 (HEI-2015) and dietary phytochemical index (DPI) were calculated by semi-quantitative food frequency questionnaire (FFQ). In both crude and adjusted model for confounding factors, we observed significant interactions between DQI-I and Ins/Del SNP on leptin in and 8-iso-prostaglandin F2 α (8-iso-PGF2α), DPI and EcoR1 SNP on total cholesterol (TC) and between Ins/Del SNP and HEI-2015 on interleukin-18 (IL-18). Furthermore, in crude model there were close to meaningful interactions between EcoR1 SNP and DQI-I on total antioxidant capacity (TAC) and between EcoR1 SNP and HEI-2015 on serum leptin and superoxide dismutase (SOD) levels. Our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene.

Baru Nut Intake and Resistance Training Practice Have Potential to Reduce the Cardiometabolic Risk Factors in Type 2 Diabetes

2021 ◽  
Vol 17 ◽  
Author(s):  
John Sebastião Cardoso da Silva ◽  
Maria Sebastiana Silva ◽  
Maria Margareth Veloso Naves
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Resistance Training ◽  
Cardiometabolic Risk ◽  
Nutritional Composition ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Health

Background: Type 2 diabetes mellitus (T2DM) is a disease associated with several cardiometabolic risk factors (CMRF). There is strong evidence about the benefits of oilseeds intake and the practice of resistance training (RT) in the prevention and treatment of T2DM and its associated CMRF. However, no study has evaluated the combination of these interventions yet. Baru nut, an oilseed native to the Brazilian Cerrado, stands out among oilseeds due to its healthy nutritional composition, which have the potential to reduce CMRF in T2DM. RT, in turn, provides positive changes in the composition and metabolism of muscle cells, which contributes to improving cardiometabolic health. Objective: This review aimed to summarize the effects and mechanisms related to the intake of baru nut and the practice of RT in reducing CMRF in T2DM. Method: Literature research was performed using the keywords "type 2 diabetes mellitus", "Dipteryx alata Vog", "nuts", "physical exercise" and "resistance training", isolated or associated, in Web of Science and Pubmed databases. Results: Baru nut is an oilseed with high density of nutrients and bioactive compounds with antioxidant and antihypercholesterolemic properties, and the RT is associated with beneficial effects on CMRF in T2DM individuals. Thus, the consumption of baru nut and the RT have potential to improve the insulin sensitivity, glycemic control, body composition, and serum lipid profile. Conclusion: The baru nut consumption and the RT have potential to reduce the cardiometabolic risk factors in T2DM. Both interventions are innovative and promising approaches to preserve the health of T2DM individuals.

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