The diagnosis of Gestational Diabetes Mellitus and its impact on In Vitro Fertilization pregnancies. A pilot study

Gestational diabetes mellitus (GDM) may be related to intestinal mucosal damage and inflammation-induced dysbiosis of secretory IgA (SIgA) coated microbiota. SIgA coated L. reuteri can reduce the level of inflammation of GDM in vitro.

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Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study

Obstetric Medicine ◽

10.1177/1753495x17701320 ◽

2017 ◽

Vol 10 (3) ◽

pp. 120-124 ◽

Cited By ~ 6

Author(s):

Margaret Bublitz ◽

Suzanne De La Monte ◽

Susan Martin ◽

Lucia Larson ◽

Ghada Bourjeily

Keyword(s):

Diabetes Mellitus ◽

Pilot Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Birth Outcomes ◽

Childhood Maltreatment ◽

Secondary Data ◽

Past Research ◽

Increased Risk

Background Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. Methods This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol. Birth outcomes for past and current pregnancies were recorded. Results Histories of maltreatment were associated with elevated interleukin-15 and a marginally greater incidence of preterm delivery in current and past pregnancies. Conclusions This pilot study was the first to demonstrate an association between childhood maltreatment history and inflammatory cytokine levels in pregnant women diagnosed with gestational diabetes mellitus.

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Investigating apoptotic, inflammatory, and growth markers in poor responders undergoing natural in vitro fertilization cycles: a pilot study

Annals of the New York Academy of Sciences ◽

10.1111/nyas.14517 ◽

2020 ◽

Author(s):

Konstantinos Sfakianoudis ◽

Petroula Tsioulou ◽

Evangelos Maziotis ◽

Sokratis Grigoriadis ◽

Argyro Glava ◽

...

Keyword(s):

Pilot Study ◽

In Vitro Fertilization ◽

Poor Responders ◽

Vitro Fertilization

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miR-657 Promotes Macrophage Polarization toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus

Mediators of Inflammation ◽

10.1155/2019/4851214 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Pingping Wang ◽

Zengfang Wang ◽

Guojie Liu ◽

Chengwen Jin ◽

Quan Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Macrophage Polarization ◽

Vital Role ◽

Luciferase Reporter ◽

M2 Macrophage ◽

And Migration

MicroRNA (miRNA) has been widely suggested to play a vital role of in the pathogenesis of gestational diabetes mellitus (GDM). We have previously demonstrated that miR-657 can regulate macrophage inflammatory response in GDM. However, the role of miR-657 on M1/M2 macrophage polarization in GDM pathogenesis is not clear yet. This study is aimed at elucidating this issue and identifying novel potential GDM therapeutic targets based on miRNA network. miR-657 is found to be upregulated in placental macrophages demonstrated by real-time PCR, which can enhance macrophage proliferation and migration in vitro. Luciferase reporter assay shows the evidence that FAM46C is a target of miR-657. In addition, miR-657 can promote macrophage polarization toward the M1 phenotype by downregulating FAM46C in macrophages. The present study strongly suggests miR-657 is involved in GDM pathogenesis by regulating macrophage proliferation, migration, and polarization via targeting FAM46C. miR-657/FAM46C may serve as promising targets for GDM diagnosis and treatment.

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