scholarly journals EVAR and OPEN treatment of abdominal aortic aneurysm: What is the role of MMP-9 in the follow-up?

2017 ◽  
Vol 42 (1) ◽  
pp. 21-28 ◽  
Author(s):  
A. Ascoli Marchetti ◽  
G. Pratesi ◽  
L. Di Giulio ◽  
M. Battistini ◽  
R. Massoud ◽  
...  
Author(s):  
S. Zeinali-Davarani ◽  
A. Dupay ◽  
S. Baek ◽  
W. Lee

The role of spine and other surrounding tissues as geometrical constraints on abdominal aortic aneurysm (AAA) enlargement has been suggested [1] but its biomechanical effects among patients have not been thoroughly investigated yet. In this study, we use longitudinal CT images obtained from AAA follow-up studies and investigate geometrical features and their changes indicating interactions with spine during the progression of AAAs. We also study biomechanical effects of the interaction with spine on the AAA enlargement and stress distribution using growth and remodeling (G&R) model of AAAs.


2020 ◽  
Vol 27 (6) ◽  
pp. 889-901
Author(s):  
Konstantinos Spanos ◽  
Petroula Nana ◽  
Christian-Alexander Behrendt ◽  
George Kouvelos ◽  
Giuseppe Panuccio ◽  
...  

The development of endovascular techniques has improved abdominal aortic aneurysm (AAA) management over the past 2 decades. Different cardiovascular societies worldwide have recommended the endovascular approach as the standard of care in their currently available guidelines. While endovascular treatment has established its role in daily clinical practice, a new debate has arisen regarding the indications, appropriateness, limitations, and role of open surgery. To inform this debate, the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched from 2010 to May 2020; the systematic search identified 5 articles published between 2011 and 2020 by 4 cardiovascular societies and the National Institute of Health and Care Excellence (NICE). Four debatable domains were assessed and analyzed: diagnostic methods and screening, preoperative management, indications and treatment modalities, and postoperative follow-up and endoleak management. The review addresses controversial proposals as well as widely accepted recommendations and “gray zone” issues that need to be further investigated and analyzed, such as screening in women, medical management, and follow-up imaging. While the recommendations for AAA management have significant overlap and agreement among international cardiovascular societies, the NICE guidelines diverge regarding the role of open repair in aortic disease, recommending conventional surgery in most elective cases.


Author(s):  
Richa Gandhi ◽  
Michael Bell ◽  
Marc Bailey ◽  
Charalampos Tsoumpas

AbstractAbdominal aortic aneurysm (AAA) disease is characterized by an asymptomatic, permanent, focal dilatation of the abdominal aorta progressing towards rupture, which confers significant mortality. Patient management and surgical decisions rely on aortic diameter measurements via abdominal ultrasound surveillance. However, AAA rupture can occur at small diameters or may never occur at large diameters, implying that anatomical size is not necessarily a sufficient indicator. Molecular imaging may help identify high-risk patients through AAA evaluation independent of aneurysm size, and there is the question of the potential role of positron emission tomography (PET) and emerging role of novel radiotracers for AAA. Therefore, this review summarizes PET studies conducted in the last 10 years and discusses the usefulness of PET radiotracers for AAA risk stratification. The most frequently reported radiotracer was [18F]fluorodeoxyglucose, indicating inflammatory activity and reflecting the biomechanical properties of AAA. Emerging radiotracers include [18F]-labeled sodium fluoride, a calcification marker, [64Cu]DOTA-ECL1i, an indicator of chemokine receptor type 2 expression, and [18F]fluorothymidine, a marker of cell proliferation. For novel radiotracers, preliminary trials in patients are warranted before their widespread clinical implementation. AAA rupture risk is challenging to evaluate; therefore, clinicians may benefit from PET-based risk assessment to guide patient management and surgical decisions.


2010 ◽  
Vol 39 (1) ◽  
pp. 42-48 ◽  
Author(s):  
E. Georgakarakos ◽  
C.V. Ioannou ◽  
Y. Kamarianakis ◽  
Y. Papaharilaou ◽  
T. Kostas ◽  
...  

2011 ◽  
Vol 91 (2) ◽  
pp. 358-367 ◽  
Author(s):  
Hidehiro Kaneko ◽  
Toshihisa Anzai ◽  
Toshiyuki Takahashi ◽  
Takashi Kohno ◽  
Masayuki Shimoda ◽  
...  

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