Recurrent life-threatening hyperkalemia without typical electrocardiographic changes

2014 ◽  
Vol 47 (1) ◽  
pp. 95-97 ◽  
Author(s):  
Himad K. Khattak ◽  
Shahram Khalid ◽  
Kamran Manzoor ◽  
Phyllis K. Stein
Keyword(s):  
Life Threatening ◽  
Electrocardiographic Changes

scholarly journals Electrocardiographic safety of daily Hydroxychloroquine 400mg plus Azithromycin 250mg as an ambulatory treatment for COVID-19 patients in Cameroon

2020 ◽  
Author(s):  
Liliane Mfeukeu-Kuate ◽  
William Ngatchou ◽  
Mazou Ngou Temgoua ◽  
Charles Kouanfack ◽  
Daniel Lemogoum ◽  
...  
Keyword(s):  
National Standard ◽  
Qtc Interval ◽  
Rt Pcr ◽  
Ambulatory Treatment ◽  
Outcomes Measures ◽  
Life Threatening ◽  
Secondary Endpoints ◽  
Electrocardiographic Changes ◽  
Qrs Duration ◽  
The City

AbstractObjectiveTo determine the early electrocardiographic changes in a cohort of ambulatory cameroonian COVID-19 patients treated with hydroxychloroquine and Azithromycin.DesignProspective study.SettingTreatment centres of the city of Yaounde, Cameroon, from May 7th to 24th 2020.ParticipantsWe enrolled 51 consecutive confirmed COVID-19 on RT-PCR who having mild forms of COVID-19 and treated by hydroxychloroquine 200mg twice daily during seven days plus Azithromycin 500 mg the first day and 250 mg the remaining 4 days as per national standard.Main outcomes measuresThe primary end-point was the change in QTc interval between day 0 (D0), day 3 (D3) and day 7 (D7). Secondary endpoints were changes in all other cardiac electrical conductivity patterns and the occurrence of clinical arrhythmic events during the course of treatment.ResultsThe population (29 men and 22 women) was aged 39 ± 11 years (range 17 to 61 years). Mean Tisdale score was 3.35±0.48. No significant change from baseline (D0) of QTc was observed at D7 (429±27 ms at D0 versus 396±26 ms at D7; p=0.27). A reduction of heart rate was observed between the D0 and D7 (75±13 bpm versus 70±13 bpm, p = 0.02) with increased QRS duration between D0 and D7 (95±10 ms versus 102±17 ms, p = 0.004). No symptomatic arrhythmic events occurred during the treatment course.ConclusionsNo life-threatening modifications of the QT interval was observed in non-severe COVID-19 patients treated ambulatory with hydroxychloroquine and azithromycin. Studies are needed in critical-ill and older patients.

scholarly journals Severe hyperkalemia induced by propranolol

2014 ◽  
Vol 67 (5-6) ◽  
pp. 181-184 ◽  
Author(s):  
Danijela Mandic ◽  
Lana Nezic ◽  
Ranko Skrbic
Keyword(s):  
Beta Blockers ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
Monitoring Centre ◽  
Life Threatening ◽  
Severe Hyperkalemia ◽  
Electrocardiographic Changes ◽  
Therapeutic Measures ◽  
Health Organization ◽  
Relationship Of

Introduction. Hyperkalemia secondary to beta-adrenergic receptor blockade occurs in 1-5% of patients and is likely to develop with non-cardio-selective beta-blockers. Case Report. We have described hyperkalemia in a patient with angina pectoris receiving propranolol, clinically manifested as weakness, tightness behind the sternum and numbness in the limbs. Laboratory tests showed hyperkalemia (6.6 mmol/L), peaked T wave and a corrected QT interval of 510 ms. After discontinuation of propranolol, decline in potassium level, normalisation of electrocardiographic changes and clinical improvement were achieved. Causal relationship of drug related hyperkalemia has been confirmed as probable/likely according to Naranjo Adverse Drug Reaction Probability Score of 7 and the World Health Organization Uppsala Monitoring Centre Probability Scale. Conclusion. Hyperkalemia can be unpredictable and life-threatening complication of propranolol or a non-selective adrenergic beta blocker treatment, and requires timely identification of cause and implementation of therapeutic measures.

Electrocardiographic Changes Associated With a Life-Threatening Condition

2019 ◽  
Vol 28 (1) ◽  
pp. 85-86
Author(s):  
Salah S. Al-Zaiti ◽  
Ziad Faramand ◽  
Teri M. Kozik ◽  
Michele M. Pelter ◽  
Mary G. Carey
Keyword(s):  
Threatening Condition ◽  
Life Threatening ◽  
Electrocardiographic Changes

scholarly journals Life-threatening hyperkalemia with minimal electrocardiographic changes: a case report

2014 ◽  
Vol 21 (2) ◽  
pp. 189-190
Author(s):  
Takako Sasai ◽  
Etsu Iwasaki ◽  
Yuri Oishi ◽  
Mizue Ishii ◽  
Hiroyuki Kobayashi ◽  
...  
Keyword(s):  
Case Report ◽  
Life Threatening ◽  
Electrocardiographic Changes

Getting stung by black scorpion Androctonus crassicauda

2013 ◽  
Vol 33 (10) ◽  
pp. 1081-1084 ◽  
Author(s):  
A Aghabiklooei ◽  
N Zamani ◽  
H Hassanian-Moghaddam
Keyword(s):  
Myocardial Infarction ◽  
Low Dose ◽  
Correct Diagnosis ◽  
Scorpion Sting ◽  
Early Management ◽  
Scorpion Envenomation ◽  
Life Threatening ◽  
Electrocardiographic Changes ◽  
Unknown Object ◽  
Black Scorpion

Importance of the correct diagnosis in the correct early management of a scorpion stung patient by using antivenom is not emphasized, particularly when there are little evidences. A 65-year-old female was brought to our emergency department with the chief compliant of being stung by an unknown object 3 h earlier while traveling in an intercity bus. She became agitated and simultaneously experienced tachycardia, very severe generalized sweating, cold and wet extremities, bilateral diffuse crackle in the base of lungs, tachypnea, and lethargy. With the primitive diagnosis of myocardial infarction, scorpion sting was documented as the cause of this combined cholinergic and adrenergic syndrome after the scorpion was found in the patient’s bed clothes. She dramatically responded to the administration of low dose of scorpion antivenom. This case dramatically responded to the antivenom administration, especially the cholinergic and sympathetic signs, pulmonary edema, and electrocardiographic changes were fully and almost immediately recovered. Scorpion antivenom may reverse life-threatening manifestations of scorpion envenomation if used early and in appropriate patients.

scholarly journals Mecanismos das alterações eletrocardiográficas na hiperpotassemia / Mechanisms of electrocardiographic changes in hyperkalemia

2020 ◽  
Vol 65 (1) ◽  
pp. 1
Author(s):  
Gabriel Martinez ◽  
Marco Antonio Dias
Keyword(s):  
Systematic Review ◽  
Early Treatment ◽  
Cardiac Cells ◽  
Review Of The Literature ◽  
Threatening Condition ◽  
Life Threatening ◽  
Electrocardiographic Changes

Introdução: A hiperpotassemia é uma condição que ameaça a vida se não identificada e tratada devidamente. Objetivo: Este trabalho tem por objetivo descrever as principais alterações eletrocardiográficas secundárias à hiperpotassemia. Métodos: Foi realizada uma revisão não sistemática de literatura dos últimos dez anos, pautada nos descritores e nos termos mais utilizados para hiperpotassemia, tendo como base LILACS, SciELO e PubMed. Resultados e conclusão: O conhecimento da fisiopatologia da hiperpotassemia sobre a célula cardíaca e sua consequente modificação eletrocardiográfica possibilita a identificação precoce desta situação antes mesmo da confirmação laboratorial, permitindo tratamento precoce e redução na mortalidade. Palavras-chave: Hiperpotassemia, Eletrocardiografia, fisiopatologia.ABSTRACTIntroduction: Hyperkalemia is a life-threatening condition if it doesn’t get identified and treated correctly. Objective: This work aims to describe the main electrocardiography’s modification due to hyperkalemia. Method: A non-systematic review of the literature of the last ten years was carried out, based on the descriptors and terms most used for hyperkalemia, based on LILACS, SciELO and PubMed. Result and Conclusion: The knowledge of hyperkalemia’s physiopathology acting in cardiac cells and it’s consequent electrocardiografic modification allows to identify prematurely this situation just before laboratory’s result, providing early treatment and reduction in mortality.Keywords: Hyperkalemia, Electrocardiography, Physiopathology Introdução

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

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