scholarly journals Severe hyperkalemia induced by propranolol

2014 ◽  
Vol 67 (5-6) ◽  
pp. 181-184 ◽  
Author(s):  
Danijela Mandic ◽  
Lana Nezic ◽  
Ranko Skrbic
Keyword(s):  
Beta Blockers ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
Monitoring Centre ◽  
Life Threatening ◽  
Severe Hyperkalemia ◽  
Electrocardiographic Changes ◽  
Therapeutic Measures ◽  
Health Organization ◽  
Relationship Of

Introduction. Hyperkalemia secondary to beta-adrenergic receptor blockade occurs in 1-5% of patients and is likely to develop with non-cardio-selective beta-blockers. Case Report. We have described hyperkalemia in a patient with angina pectoris receiving propranolol, clinically manifested as weakness, tightness behind the sternum and numbness in the limbs. Laboratory tests showed hyperkalemia (6.6 mmol/L), peaked T wave and a corrected QT interval of 510 ms. After discontinuation of propranolol, decline in potassium level, normalisation of electrocardiographic changes and clinical improvement were achieved. Causal relationship of drug related hyperkalemia has been confirmed as probable/likely according to Naranjo Adverse Drug Reaction Probability Score of 7 and the World Health Organization Uppsala Monitoring Centre Probability Scale. Conclusion. Hyperkalemia can be unpredictable and life-threatening complication of propranolol or a non-selective adrenergic beta blocker treatment, and requires timely identification of cause and implementation of therapeutic measures.

scholarly journals Pharmacovigilance programme of India: revival of the renaissance

2018 ◽  
Vol 7 (11) ◽  
pp. 2281
Author(s):  
Jyoti B. Gadhade ◽  
Rajesh S. Hiray ◽  
Rekha Y. Aherkar ◽  
Kalpana U. Shah
Keyword(s):  
Adverse Drug Reactions ◽  
Adverse Drug Reaction Reporting ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
Family Welfare ◽  
Drug Reactions ◽  
Monitoring Centre ◽  
The World ◽  
Health Organization

Adverse drug reactions (ADRs) are the fourth leading cause of morbidity in the world. In order to safeguard the health of the community, Pharmacovigilance Programme of India (PvPI) is implemented as the monitoring body by Indian Pharmacopoeia Commission (IPC). It is leading national authority. National Coordinating Centre (NCC) PvPI works as the World Health Organization (WHO) collaborating centre for pharmacovigilance. Adverse drug reactions are reported to NCC PvPI which are then directed towards WHO Uppsala Monitoring Centre (UMC) Sweden which is the global monitoring centre for worldwide data. Central Drugs Standard Control Organization (CDSCO) is the regulatory authority of India under the Ministry of Health and Family Welfare (MOHFW), Government of India. This article focusses on the various strands of pharmacovigilance at the healthcare professional and consumer level. It also discusses the pitfalls in the journey of pharmacovigilance thus helping in enhancing the quality of health safety. Even a minuscule contribution by a health care professional or a consumer can voluminously help in promotion of drug safety. Therefore, there is a need of inculcating the culture of adverse drug reaction reporting for the welfare of the vulnerable masses.

scholarly journals Adverse ocular events on miltefosine treatment for post-kala-azar dermal leishmaniasis in India

2019 ◽  
Vol 50 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Suman Saurabh ◽  
Manish Mahabir
Keyword(s):  
Safety Information ◽  
Corneal Transplantation ◽  
Case Series ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
Corneal Ulceration ◽  
Monitoring Centre ◽  
Kala Azar ◽  
Primary Health Centres ◽  
Health Organization

A 12-week course of miltefosine (MF) is recommended in India for the treatment of post-kala-azar dermal leishmaniasis (PKDL). We report a case series of four patients with PKDL, across three districts of Bihar state, who developed eye complications during treatment. They presented with acute scleritis and corneal infiltration with or without corneal ulceration. One patient solely with corneal infiltration recovered completely. The three others with corneal ulceration healed with corneal opacificity. One patient with bilateral eye involvement underwent corneal transplantation to prevent blindness. All adverse events were graded as certain using the World Health Organization-Uppsala Monitoring Centre causality assessment scale. There is need to counsel patients regarding possible adverse ocular events during MF treatment, to expand pharmacovigilance to all primary health centres in kala-azar endemic areas, and to update drug safety information considering the emerging evidence.

scholarly journals ALLOPURINOL-INDUCED STEVENS–JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS: A CASE REPORT

2019 ◽  
pp. 5-7 ◽  
Author(s):  
MANIK CHHABRA ◽  
ANKIT GAUR
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
World Health ◽  
Stevens Johnson Syndrome ◽  
Uppsala Monitoring Centre ◽  
Self Medication ◽  
Monitoring Centre ◽  
Johnson Syndrome ◽  
Chief Complaints ◽  
Health Organization ◽  
Uppsala Monitoring

Allopurinol is used for the treatment of gout and related conditions; it is associated with various adverse drug reactions (ADRs) such as Stevens– Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). A 50-year-old female was presented to the emergency ward with chief complaints of reddish pinpoint lesions over the back, chest, abdomen, and lower limb-upper limb for the past 6 days. She was diagnosed with SJS. On medication interview, it was revealed that she was on allopurinol therapy, which she took 5 days back as a self-medication. The World Health Organization - Uppsala Monitoring Centre (WHO) scale was used to access the causality assessment, ADR was found to be probable. The drug was withdrawn from the therapeutic regimen of the patient. The patient was discharged after 25 days from the hospital. Allopurinol has the strongest association with SJS with TEN. There should be a screening of HLA-B 5801 antigens before commencing the allopurinol therapy to the patients.

scholarly journals Ofloxacin-induced maculopapular rash in the infant

2018 ◽  
Vol 7 (11) ◽  
pp. 2261
Author(s):  
Amit S. Kamdi ◽  
Pankaj N. Bohra ◽  
Suvarna M. Kalambe
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Bacterial Infections ◽  
Rare Condition ◽  
Maculopapular Rash ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
Monitoring Centre ◽  
Pediatric Age Group ◽  
Health Organization

Adverse drug reactions (ADRs) are a major cause of morbidity and mortality in countries having limited healthcare resources. The ofloxacin is an antimicrobial used for treating several bacterial infections. The ofloxacin, belonging to quinolone group of drugs, is bactericidal and acts by inhibition of bacterial DNA gyrase. Among the adverse drug reaction of ofloxacin, skin rashes are rare. An ofloxacin-induced maculopapular rash is the unique rare condition in the infant. The present case report was assessing the causality in ofloxacin induced maculopapular rash in the infant. Naranjo Adverse Drug Reaction Probability Scale and World Health Organization and Uppsala Monitoring Centre (WHO-UMC) system for standardized case causality assessment were used for assessing the causality. According to the Naranjo and WHO-UMC, ofloxacin scaled as the probable/likely cause of this ADR in infant. So, authors can conclude that the ofloxacin should be used cautiously in the pediatric age group.

scholarly journals A 10-Year Single-Center Experience of Adverse Drug Reaction Monitoring

2021 ◽  
Vol 96 (4) ◽  
pp. 341-351
Author(s):  
Soo Been Park ◽  
Mira Moon ◽  
Hyun Hwa Kim ◽  
Ga-Yoon Park ◽  
Dong Yoon Kang ◽  
...  
Keyword(s):  
Individual Case ◽  
University Hospital ◽  
World Health ◽  
Uppsala Monitoring Centre ◽  
System Organ Class ◽  
Serious Adverse Events ◽  
Monitoring Centre ◽  
Single Center Experience ◽  
National University ◽  
Health Organization

Background/Aims: Despite proper use of pharmaceuticals, adverse drug reactions (ADRs) can lead to problems related to patient safety. We analyzed the characteristics of ADRs, particularly serious adverse events (SAEs), in a single tertiary medical institution. Methods: Spontaneous ADR report data collected from 2010 to 2019 in Seoul National University Hospital were assessed. Causality was evaluated according to the World Health Organization-Uppsala Monitoring Centre criteria. Age, sex, onset, severity, seriousness, and system organ class (SOC) of ADRs and SAEs were analyzed. Results: During the study period, a total of 49,955 individual case safety reports were assessed as possible, probable, or certain. Although the number of gastrointestinal ADR reports was high (25.9%), severe cases were uncommon (2.6%). By contrast, the number of hematologic disorders was low (6.6%) but 39.2% of them were severe. Among ADRs, 10.2% were assessed as SAEs, the proportion of which was high at extreme ages and in males. Body as a whole-general disorders were the most frequently reported SOC for SAEs, followed by skin and appendage disorders. Antineoplastic agents and antibiotics were the most common causative agents of SAEs and ADRs. Anaphylactic reaction was the most frequent SAE (6.5%). Conclusions: The proportion of SAE differs according to SOC and drug. Attention should be paid to SAEs in children and older adults because the rate of SAEs is significantly higher at extreme ages.

Comparativa de modelos multivariados basados en aprendizaje automático para la predicción del riesgo de diabetes en etapas tempranas

2021 ◽  
Author(s):  
◽  
Zayra Ramírez Gaytán
Keyword(s):  
World Health ◽  
Degenerative Diseases ◽  
Decision Tree Algorithm ◽  
Data Set ◽  
The World ◽  
Long Time ◽  
Life Threatening ◽  
Health Organization ◽  
Logistic Regression Algorithm ◽  
Asymptomatic Phase

Diabetes is one of the fastest-growing, life-threatening, chronic degenerative diseases. According to the World Health Organization (WHO), it has affected 422 million people worldwide in 2018. Approximately 50% of all people who suffer diabetes are not diagnosed due to the asymptomatic phase which usually lasts a long time. In this work, a data set of 520 instances has been used. The data set has been analyzed with the next three algorithms: logistic regression algorithm, decision trees and random forest. The results show that the decision tree algorithm had better performance with an AUC of 98%. Also, it was found the most common symptoms that a person with a risk of diabetes presents are polyuria, polydipsia and sudden weight loss.

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