:
In recent years, over use of antibiotics has been raising its head to a serious problem
all around the world as pathogens become drug resistant and create challenges to the medical
field. This failure of most potent antibiotics that kill pathogens increases the thirst for
research to look further way of killing pathogens. It has been led to the findings of
antimicrobial peptide which is the most potent peptide to destroy pathogens. This review
gives special emphasis to the usage of marine bacteria and other microorganisms for
antimicrobial peptide (AMP) which are eco friendly as well as a developing class of natural
and synthetic peptides with a wide spectrum of targets to pathogenic microbes. Consequently,
a significant attention has been paid mainly to (i) the structure and types of anti microbial
peptides and (ii) mode of action and mechanism of antimicrobial peptide resistance to
pathogens. In addition to this, the designing of AMPs has been analysed thoroughly for
reducing toxicity and developing better potent AMP. It has been done by the modified
unnatural amino acids by amidation to target the control of biofilm and persister cell.
