Potential Antimicrobial Peptides Elucidation From The Marine Bacteria

2020 ◽  
Vol 18 ◽  
Author(s):  
Adyasa Barik ◽  
Pandiyan Rajesh ◽  
Manthiram Malathi ◽  
Vellaisamy Balasubramanian
Keyword(s):  
Antimicrobial Peptide ◽  
Marine Bacteria ◽  
Unnatural Amino Acids ◽  
Wide Spectrum ◽  
Drug Resistant ◽  
Medical Field ◽  
The World ◽  
Pathogenic Microbes ◽  
Antimicrobial Peptide Resistance ◽  
Significant Attention

: In recent years, over use of antibiotics has been raising its head to a serious problem all around the world as pathogens become drug resistant and create challenges to the medical field. This failure of most potent antibiotics that kill pathogens increases the thirst for research to look further way of killing pathogens. It has been led to the findings of antimicrobial peptide which is the most potent peptide to destroy pathogens. This review gives special emphasis to the usage of marine bacteria and other microorganisms for antimicrobial peptide (AMP) which are eco friendly as well as a developing class of natural and synthetic peptides with a wide spectrum of targets to pathogenic microbes. Consequently, a significant attention has been paid mainly to (i) the structure and types of anti microbial peptides and (ii) mode of action and mechanism of antimicrobial peptide resistance to pathogens. In addition to this, the designing of AMPs has been analysed thoroughly for reducing toxicity and developing better potent AMP. It has been done by the modified unnatural amino acids by amidation to target the control of biofilm and persister cell.

ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE

2012 ◽  
pp. 84-89
Author(s):  
Quoc Hung Vo ◽  
Nguyen Phuong Nhi Doan ◽  
Dinh Quynh Phu Nguyen ◽  
Thi Dieu Tram Ho ◽  
Thi Hoai Nguyen
Keyword(s):  
Mass Spectrometry ◽  
Soft Coral ◽  
Normal Phase ◽  
Ionization Mass ◽  
Medical Field ◽  
Bioactive Substances ◽  
Anti Cancer ◽  
The World ◽  
Pure Compounds ◽  
Layer Chromatography

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.

The potential role of tea in periodontal therapy: An updated review

2020 ◽  
Vol 17 ◽  
Author(s):  
Ali Forouzanfar ◽  
Hamideh Sadat Mohammadipour ◽  
Fatemeh Forouzanfar
Keyword(s):  
Green Tea ◽  
Potential Role ◽  
Wide Spectrum ◽  
Periodontal Diseases ◽  
Herbal Remedies ◽  
World Population ◽  
Tea Leaves ◽  
The World ◽  
Green Tea Leaves

: Periodontal diseases are highly prevalent and can affect high percentage of the world population. Oxidative stress and inflammation plays an important role in the pathogenesis of periodontal diseases. Nowadays, more attention has been focused on the herbal remedies in the field of drug discovery. Green tea is an important source of polyphenol antioxidants, it has long been used as a beverage worldwide. The most interesting polyphenol components of green tea leaves that are related with health benefits are the catechins. Taken together this review suggested that green tea with its wide spectrum of activities could be a healthy alternative for controlling the damaging reactions seen in periodontal diseases.

Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance inBurkholderia cenocepacia†

2012 ◽  
Vol 85 (5) ◽  
pp. 962-974 ◽  
Author(s):  
Mohamad A. Hamad ◽  
Flaviana Di Lorenzo ◽  
Antonio Molinaro ◽  
Miguel A. Valvano
Keyword(s):  
Antimicrobial Peptide ◽  
Antimicrobial Peptide Resistance

Modernité et néo-clercs

1982 ◽  
Vol 29 (4) ◽  
pp. 283-295 ◽  
Author(s):  
Josianne Bodart
Keyword(s):  
Social Work ◽  
Social Worker ◽  
Turn Of The Century ◽  
The Body ◽  
Mutual Aid ◽  
Medical Field ◽  
Reference Models ◽  
The Social ◽  
The World ◽  
And Training

While mutual aid is secular, social work as a profession is not yet a hundred years old, and training in this field only began at the turn of the century. Neither priest nor doctor, but equally devoted and competent, the social worker is half-way between the two. His relay function is mediatized by a salary received not from his client, but from an institution which acknowledges he has a cer tain effectiveness. Social work thus reminds us at one and the same time of the priest's priesthood and the doctor's specializa tion. This neo-cleric treats the soul as well as the body and he has ambiguous relations with spelialized institutions which are in pur suit of the sacred or in pursuit of health. The social worker tries to find reference models both in the religious world and in the medi cal world. Furthermore, an analysis of his discourse reveals that he mobilizes items of counter-legitimacy with respect to both the religious and the medical field. This intentionally marginal belonging to two worlds leads him to constantly have doubts about the objectives to be pursued and the decisions to be taken. It is probably in this perspective that the feeling of uneasiness which persuades the world of social work and which prevents these professionals from getting away from vagueness and uncertainty, should be understood.

AEROPONICS AND FITOPYRАMIDA AND MODERN RESOURCE - SAVING MODERN TECHNOLOGIES FOR THE CULTIVATION OF VEGETABLE CROPS

2021 ◽  
Author(s):  
K.K. Farawn ◽  
◽  
V.I. Leunov ◽  
Keyword(s):  
Energy Conservation ◽  
Limited Resources ◽  
Vegetable Crops ◽  
Resource Saving ◽  
Human Interference ◽  
Modern Agriculture ◽  
Plant Cultivation ◽  
The World ◽  
Significant Attention ◽  
Modern Technologies

The article discusses the features of two methods of soilless technology in the context of solving the problems of resource and energy conservation in the production of vegetables. In recent years, Fitopyramida techniques have achieved significant attention in agriculture. It is applied in agriculture to plan the several activities and missions properly by utilising limited resources with minor human interference. Currently, plant cultivation, using new agriculture methods is very popular among the growers. The aeroponics and Fitopyramida are methods of modern agriculture which is commonly practiced around the world.

Grounds of Natural Philosophy

2019 ◽  
pp. 130-150
Author(s):  
David Cunning
Keyword(s):  
Natural Philosophy ◽  
Wide Spectrum ◽  
Active Regions ◽  
Empty Space ◽  
Existence Of God ◽  
The World ◽  
Self Knowledge ◽  
Philosophical Debates ◽  
Self Motion ◽  
Selection Of

This chapter features a selection of excerpts from Cavendish’s book, Grounds of Natural Philosophy. The passages treat a number of topics and issues: materialism; empty space and the impossibility of vacuum; the identity of a body and its location; the impossibility of immaterial motion; the different kinds of matter; order vs. disorder; active regions of the world that we do not notice; self-motion; self-knowledge; panpsychism; sensory perception and patterning; dreams; occasionalism; causality; chance; freedom, the cooperation of the parts of nature; individuation; natural productions vs. artefacts; imagination; fame; the afterlife; God; and belief in the existence of God. Cavendish enters into a wide spectrum of philosophical debates in Grounds of Natural Philosophy, but much of the focus is on arguments for materialism, the distinction between rational matter and sensitive matter, the knowledge and information that is shared among creatures, individuation, and the sophistication of natural (as opposed to artificial) productions.

scholarly journals TB Elimination Requires Discovery and Development of Transformational Agents

2020 ◽  
Vol 10 (7) ◽  
pp. 2605 ◽  
Author(s):  
Christian Lienhardt ◽  
Mario C. Raviglione
Keyword(s):  
Rapid Detection ◽  
Susceptibility Testing ◽  
Drug Susceptibility ◽  
Drug Susceptibility Testing ◽  
New Drugs ◽  
World Health ◽  
Drug Resistant ◽  
The World ◽  
Health Organization ◽  
Combination Regimens

The World Health Organization (WHO) End Tuberculosis (TB) Strategy has set ambitious targets to reduce 2015 TB incidence and deaths by 80% and 90%, respectively, by the year 2030. Given the current rate of TB incidence decline (about 2% per year annually), reaching these targets will require new transformational tools and innovative ways to deliver them. In addition to improved tests for early and rapid detection of TB and universal drug-susceptibility testing, as well as novel vaccines for improved prevention, better, safer, shorter and more efficacious treatments for all forms of TB are needed. Only a handful of new drugs are currently in phase II or III clinical trials, and a few combination regimens are being tested, mainly for drug-resistant TB. In this article, capitalising on an increasingly rich medicine pipeline and taking advantage of new methodological designs with great potential, the main areas where progress is needed for a transformational improvement of treatment of all forms of TB are described.

Antimicrobial peptide HPA3NT3-A2 effectively inhibits biofilm formation in mice infected with drug-resistant bacteria

2019 ◽  
Vol 7 (12) ◽  
pp. 5068-5083 ◽  
Author(s):  
Jong-Kook Lee ◽  
Loredana Mereuta ◽  
Tudor Luchian ◽  
Yoonkyung Park
Keyword(s):  
Antibiotic Resistance ◽  
Antimicrobial Peptide ◽  
Biofilm Formation ◽  
Extracellular Polymeric Substances ◽  
Resistant Bacteria ◽  
Bacterial Biofilms ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Serious Infections

Bacterial biofilms formed through secretion of extracellular polymeric substances (EPS) have been implicated in many serious infections and can increase antibiotic resistance by a factor of more than 1000.

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