Abnormalities in fibrinolysis at the time of admission are associated with deep vein thrombosis, mortality and disability in pediatric trauma population

SummaryAntithrombin III (At-III) was measured at the time of admission and two days later in 131 patients laid up in a coronary care unit. The patients were examined for deep-vein thrombosis (DVT) clinically and by means of 125I-fibrinogen scanning. 19 patients developed DVT. In 11 subjects with and 25 without DVT At-III decreased more than 10%. And in 7 with and 17 without DVT At-III decreased more than 15%. One person with DVT had subnormal At-III. By using decrease of At-III or subnormal initial At-III to predict DVT the following predictive value (PV) were found. Decrease ≤ 10%, PV pos.= 0.32 and PV neg. = 0.93. Decrease ≤ 15%, PV pos. = 0.32 and PV neg. = 0.90. The positive predictive values obtained were too low to let decreasing At-III give occasion for prophylactic anticoagulant treatment.

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IMPACT OF TIME OF ADMISSION ON DEEP VEIN THROMBOSIS DVT PROPHYLAXIS IN A CLOSED MEDICAL INTENSIVE CARE UNIT

CHEST Journal ◽

10.1378/chest.132.4_meetingabstracts.625c ◽

2007 ◽

Vol 132 (4) ◽

pp. 625C

Author(s):

Hani Jaouni ◽

Shadi Haddadin ◽

Lenora Adams ◽

Joshua S. Botdorf ◽

Maen B. Nusair ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Deep Vein Thrombosis ◽

Medical Intensive Care Unit ◽

Vein Thrombosis ◽

Dvt Prophylaxis ◽

Medical Intensive Care ◽

Time Of Admission ◽

Deep Vein

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Incidence and prophylaxis of deep vein thrombosis in a high risk trauma population

The American Journal of Surgery ◽

10.1016/s0002-9610(96)00079-7 ◽

1996 ◽

Vol 172 (1) ◽

pp. 13-14 ◽

Cited By ~ 28

Author(s):

L.D. Britt ◽

David Zolfaghari ◽

Elizabeth Kennedy ◽

Keith J. Pagel ◽

Anita Minghini

Keyword(s):

Deep Vein Thrombosis ◽

High Risk ◽

Vein Thrombosis ◽

Trauma Population ◽

Deep Vein

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Deep vein thrombosis screening and risk factors in a high-risk trauma population

Journal of Surgical Research ◽

10.1016/j.jss.2015.04.069 ◽

2015 ◽

Vol 199 (2) ◽

pp. 545-551 ◽

Cited By ~ 10

Author(s):

Christopher P. Michetti ◽

Elizabeth Franco ◽

Jonathan Coleman ◽

Anna Bradford ◽

Amber W. Trickey

Keyword(s):

Risk Factors ◽

Deep Vein Thrombosis ◽

High Risk ◽

Vein Thrombosis ◽

Trauma Population ◽

Deep Vein

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Effect of time of admission on compliance with deep vein thrombosis prophylaxis in a tertiary medical intensive care unit

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2009.03356.x ◽

2009 ◽

Vol 7 (6) ◽

pp. 950-954

Author(s):

O. DABBAGH ◽

L. ADAMS ◽

S. HADDADIN ◽

H. JAOUNI ◽

C. KARPMAN ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Deep Vein Thrombosis ◽

Medical Intensive Care Unit ◽

Thrombosis Prophylaxis ◽

Vein Thrombosis ◽

Deep Vein Thrombosis Prophylaxis ◽

Medical Intensive Care ◽

Time Of Admission ◽

Deep Vein

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PIH5 THE EFFECT OF INJURY SEVERITY ON THE INCIDENCE AND RESOURCE UTILIZATION-RELATED OUTCOMES OF DEEP VEIN THROMBOSIS AMONG PEDIATRIC TRAUMA ADMISSIONS IN THE UNITED STATES

Value in Health ◽

10.1016/s1098-3015(10)70779-8 ◽

2008 ◽

Vol 11 (3) ◽

pp. A246-A247

Author(s):

SD Candrilli ◽

R Balkrishnan ◽

S O'Brien

Keyword(s):

United States ◽

Deep Vein Thrombosis ◽

Resource Utilization ◽

Injury Severity ◽

Pediatric Trauma ◽

The United States ◽

Vein Thrombosis ◽

Deep Vein

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RIVAROXABAN SAFETY DURING DEEP VEIN THROMBOSIS TREATMENT IN PATIIENTS WITH RELATED DAMAGES OF STOMACH AND DUODENUM

Atherothrombosis Journal ◽

10.21518/2307-1109-2019-1-36-43 ◽

2019 ◽

pp. 36-43

Author(s):

E. A. Shcheglov ◽

N. N. Alontseva ◽

P. S. Guliaeva

Keyword(s):

Deep Vein Thrombosis ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Therapeutic Option ◽

Anticoagulant Treatment ◽

Vein Thrombosis ◽

Duodenal Bleeding ◽

Ulcerative Lesions ◽

Time Of Admission ◽

Deep Vein

The aim of this study was to assess the risk of use of rivaroxaban, which was associated with gastro-duodenal bleeding in patients with deep venous thrombosis. Methods: an analysis of anticoagulant treatment in 683 patients with deep venous phlebothrombosis. All the patients underwent fiberoptic gastroduodenoscopic procedure prior to the anticoagulant treatment. When erosive-ulcerative lesions were detected, the patients received antisecretory therapy with proton pump inhibitors along with anticoagulant therapy. Results: EGD did not show any only stomach pathology only in 10.7 percent of patients at the time of admission. A symptom-free pathology that became a diagnostic finding was identified in 53.1 percent of patients. Fiberoptic gastroduodenoscopy showed completed bleeding or bleeding that was stopped using endoscopic balloon tamponade with achievement of stable hemostasis in 12.9 patients. 59.1 percent of patients received anti-coagulant therapy with rivaroxaban (Xarelto®). In the presented series of patients with acute deep vein thrombosis, the use of rivopoxaban appeared a safe therapeutic option not only in patients with erosive-ulcerative lesions in the gastroduodenal system, but also in those with endoscopic signs of stopped bleeding (on the top of already administered antisecretory therapy with proton pump inhibitors).

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