Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats

2021 ◽  
Vol 266 ◽  
pp. 113411
Author(s):  
Tian Li ◽  
Mengmeng Hu ◽  
Cuihua Jiang ◽  
Dongjian Zhang ◽  
Meng Gao ◽  
...  
Keyword(s):  
Laxative Effect

Evaluation of the Laxative activity of Saponin Enriched Hydroethanolic Pericarp extract of Sapindus emarginatus in Animal models

2020 ◽  
Vol 16 ◽  
Author(s):  
Lalitha Vivekanandan ◽  
Roxanne Gekonge Mandere ◽  
Sivakumar Thangavel
Keyword(s):  
Animal Models ◽  
Gravimetric Analysis ◽  
Triterpene Saponins ◽  
Laxative Effect ◽  
Saponin Content ◽  
The Family ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Efficacious Drug

Background: Constipation is a common, predominant, chronic gastrointestinal functional disorder. The drugs available to treat constipation are limited because of their side effects in long term use. So we need of efficacious drug to treat constipation. Sapindus emarginatus Vahl belongs to the family Sapindaceae, commonly known as soapnut. Traditionally used for the antipruritic, antifertility, constipation, and anti-inflammatory agents. Objective: The present study was undertaken to evaluate the laxative activity of hydroethanolic pericarp extract of Sapindus emarginatus (HESE) in animal models. Methods: The saponin content in extract was measured by gravimetric analysis. The laxative activity of hydroethanolic pericarp extract of Sapindus emarginatus is evaluated by the weight of feces matter, charcoal meal hyperperistalsis test, and loperamide induced constipation model. Results: The saponin content of the soapnut pericarp was 13.48 % and the extract was found to be 11.92 %. The results obtained from these models showed a significant dose-dependent increase in fecal weight, peristalsis index, and moisture content compared to control animals. Conclusion: The present study concluded that the oral administration of HESE showed a significant laxative activity by using different animal models. The presence of triterpene saponins is responsible for this activity. Further studies are needed to confirm their mechanism behind the laxative effect. The administration of extract was found to be a valid candidate in constipation therapy.

PGE-Mediated laxative effect of diphenolic laxatives

1978 ◽  
Vol 305 (3) ◽  
pp. 241-246 ◽  
Author(s):  
E. Beubler ◽  
H. Juan
Keyword(s):  
Laxative Effect

Fermented liquid feed can reduce E. coli bloom at farrowing and prevent constipation problems during lactation

2003 ◽  
Vol 2003 ◽  
pp. 69-69
Author(s):  
V. Demečková ◽  
C.A. Tsourgiannis ◽  
P.H. Brooks ◽  
A. Campbell
Keyword(s):  
Microbial Load ◽  
Swine Production ◽  
Gastrointestinal Infections ◽  
E Coli ◽  
Neonatal Pigs ◽  
Liquid Feed ◽  
Pathogen Load ◽  
Laxative Effect ◽  
Large Numbers

Gastrointestinal infections associated with E. coli represent a serious problem for neonatal pigs. These bacteria are present in the sow’s intestine in large numbers but increase dramatically just prior to farrowing due to stress occasioned by movement and parturition (Maclean and Thomas, 1974). Consequently, just 24 hours after farrowing, E.coli are found in high numbers (over 108/g) in the faeces of piglets. However, at this stage of its life the piglet is not equipped to deal with such a large microbial load and unless immunological assistance is provided, they have very little chance of survival. In pigs, all immunological assistance at birth is concentrated in the mother’s colostrum. Thus elimination, or at least minimizing, all the factors which negatively affect the sow’s ability to produce sufficient amount of milk becomes essential challenge of each efficient swine production. The main aim of this study was to investigate the potential of fermented liquid feed (FLF) to control the pathogen load within the piglet’s environment by reducing the rapid E. coli multiplication in sows associated with farrowing. The possible laxative effect of FLF, in order to prevent constipation and the problems it causes during farrowing, was also examined.

scholarly journals Acute Toxicity and Mutagenicity Study on Branched Corn Syrup and Evaluation of Its Laxative Effect in Humans.

2001 ◽  
Vol 47 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Yuka KISHIMOTO ◽  
Shigeru WAKABAYASHI ◽  
Isao MATSUDA ◽  
Hiroaki FUDABA ◽  
Kazuhiro OHKUMA
Keyword(s):  
Acute Toxicity ◽  
Corn Syrup ◽  
Laxative Effect

Morning glory seed keeps laxative effect while retains less subchronic toxicity after being fried

2020 ◽  
Vol 251 ◽  
pp. 112522
Author(s):  
Shu-meng Ren ◽  
Wei Zhang ◽  
Xia-jing Xu ◽  
Ye Zhou ◽  
Jing-yan Guo ◽  
...  
Keyword(s):  
Morning Glory ◽  
Subchronic Toxicity ◽  
Laxative Effect

scholarly journals Maren Pills Improve Constipation via Regulating AQP3 and NF-κB Signaling Pathway in Slow Transit Constipation In Vitro and In Vivo

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yu Zhan ◽  
Xuegui Tang ◽  
Hong Xu ◽  
Shiyu Tang
Keyword(s):  
Signaling Pathway ◽  
Vital Role ◽  
Slow Transit Constipation ◽  
Dependent Manner ◽  
Water Metabolism ◽  
Laxative Effect ◽  
Irritable Bowel ◽  
Ht 29

Background. Maren pills have been used to treat constipation. Aquaporin 3 (AQP3) plays a vital role in regulating water transfer in the colon. It has been reported that the downregulation of AQP3 can regulate liquid water metabolism and intestinal permeability in irritable bowel syndrome (IBS) rats’ colon via NF-κB pathway. In this study, we investigated whether the laxative effect of Maren pills is associated with the regulation of AQP3 and NF-κB signaling pathway in the colon. Methods. The compound diphenoxylate suspension-induced STC rats received Maren pills intragastrically for 1 consecutive week to evaluate the laxative effect of Maren pills involving the regulation of AQP3 and NF-κB signaling pathway. Moreover, human intestinal epithelial cells (HT-29) were treated with drug serum to obtain in vitro data. Results. Our results revealed that treatment with Maren pills increased the stool number, moisture content of feces, and intestinal transit rate in a dose-dependent manner. Maren pills significantly increased the AQP3, fibrosis transmembrane conductance regulator (CFTR), and protein kinase A (PKA) proteins in the colon of rats and in HT-29 cells. Mechanistically, Maren pills obviously inhibited the activation of NF-κB pathway in the colon of rats and in HT-29 cells. Conclusion. These results suggest that the laxative effect of Maren pills is associated with the increased expression of AQP3 by downregulating NF-κB signal pathway.

Synergistic laxative effect of fermented rice extracts with probiotic-containing yogurt in normal rats

2014 ◽  
Vol 6 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Jong-Kwang Lee ◽  
Joo Wan Kim ◽  
Ki-Young Kim ◽  
Yu-Mi Ha ◽  
Jae Hak Sohn ◽  
...  
Keyword(s):  
Laxative Effect

scholarly journals Some Experiments on the Relative Digestibility of White and Wholemeal Breads

1912 ◽  
Vol 12 (2) ◽  
pp. 119-143 ◽  
Author(s):  
L. F. Newman ◽  
G. W. Robinson ◽  
E. T. Halnan ◽  
H. A. D. Neville
Keyword(s):  
Nutritive Value ◽  
Intestinal Wall ◽  
High Grade ◽  
Standard Meal ◽  
Considerable Portion ◽  
Laxative Effect ◽  
Wholemeal Bread ◽  
Prolonged Feeding

The problem of the comparative nutritive value of bread made from the various high grade white or “patents” flours and the so-called “standard” meal is of some interest. The inclusion of a considerable portion of the bran in standard bread is claimed to increase largely the nutritive value of the bread. It has been known for many years that wholemeal bread containing the bran particles was especially useful as an article of diet for persons suffering from constipation, the laxative effect being due partly to the mechanical presence of indigestible fibre, partly to the irritation of the intestinal wall by the sharp bran particles causing increased peristalsis. This effect is to some extent lost after prolonged feeding.

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