Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-α induced dendritic cells

2021 ◽  
pp. 114918
Author(s):  
Shujing Chen ◽  
Yun Bai ◽  
Yuan Wang ◽  
Chunxiao Liang ◽  
Kunze Du ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Immunosuppressive Effect ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Tnf Α

scholarly journals Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells

Blood ◽  
2010 ◽  
Vol 116 (26) ◽  
pp. 5875-5884 ◽  
Author(s):  
Hideaki Tanizaki ◽  
Gyohei Egawa ◽  
Kayo Inaba ◽  
Tetsuya Honda ◽  
Saeko Nakajima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Lymph Nodes ◽  
Actin Polymerization ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Acquired Immune Responses

Abstract Dendritic cells (DCs) are essential for the initiation of acquired immune responses through antigen acquisition, migration, maturation, and T-cell stimulation. One of the critical mechanisms in this response is the process actin nucleation and polymerization, which is mediated by several groups of proteins, including mammalian Diaphanous-related formins (mDia). However, the role of mDia in DCs remains unknown. Herein, we examined the role of mDia1 (one of the isoforms of mDia) in DCs. Although the proliferation and maturation of bone marrow-derived DCs were comparable between control C57BL/6 and mDia1-deficient (mDia1−/−) mice, adhesion and spreading to cellular matrix were impaired in mDia1−/− bone marrow–derived DCs. In addition, fluorescein isothiocyanate-induced cutaneous DC migration to draining lymph nodes in vivo and invasive migration and directional migration to CCL21 in vitro were suppressed in mDia1−/− DCs. Moreover, sustained T-cell interaction and T-cell stimulation in lymph nodes were impaired by mDia1 deficiency. Consistent with this, the DC-dependent delayed hypersensitivity response was attenuated by mDia1-deficient DCs. These results suggest that actin polymerization, which is mediated by mDia1, is essential for several aspects of DC-initiated acquired immune responses.

scholarly journals CD83 Knockdown in Monocyte-Derived Dendritic Cells by Small Interfering RNA Leads to a Diminished T Cell Stimulation

2007 ◽  
Vol 178 (9) ◽  
pp. 5454-5464 ◽  
Author(s):  
Alexander T. Prechtel ◽  
Nadine M. Turza ◽  
Alexandros A. Theodoridis ◽  
Alexander Steinkasserer
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Small Interfering Rna ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Interfering Rna

Dendritic cells fused with human cancer cells: morphology, antigen expression, and T cell stimulation

2004 ◽  
Vol 113 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Shigeo Koido ◽  
Masaya Ohana ◽  
Chunlei Liu ◽  
Najmosama Nikrui ◽  
John Durfee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cancer Cells ◽  
Human Cancer ◽  
Antigen Expression ◽  
Cell Stimulation ◽  
Human Cancer Cells ◽  
T Cell Stimulation

scholarly journals Retraction: Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells

2010 ◽  
Vol 184 (11) ◽  
pp. 6552-6552 ◽  
Author(s):  
Loc T. Nguyen ◽  
Bogoljub Ciric ◽  
Daren R. Ure ◽  
Bin Zhou ◽  
Koji Tamada ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Stimulation ◽  
Igm Antibody ◽  
Naturally Occurring ◽  
T Cell Stimulation
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